Calcium-Sensing Receptor Activation Depresses Synaptic Transmission

Phillips, Cecilia G.; Harnett, Mark T.; Chen, Wenyan; Sa, Smith

doi:10.1523/jneurosci.4134-08.2008

Cited by 56 publications

(76 citation statements)

References 52 publications

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“…Duration of itch. The SrCl 2 hydrogel significantly reduced the duration of itch compared to control itch curve by 79 ± 30 s (**p < 0.007), its own vehicle control by 74 s (*p < 0.05), and was superior to hydrocortisone by 109 s (***p < 0.001) and diphenhydramine by 43 s. (19). A permeability study of strontium flux thorough voltage-dependent ion channels showed that strontium traverses calcium ion channels at a greater rate than calcium itself (20).…”

Section: Discussionmentioning

confidence: 95%

A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

Papoiu¹,

Valdés‐Rodríguez²,

Nattkemper³

et al. 2013

Acta Derm Venerol

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The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic conditions. The topical strontium hydrogel formulation (TriCalm®) was tested in a head-to-head comparison with 2 common topical formulations marketed as antipruritics: hydrocortisone and diphenhydramine, for their ability to relieve cowhage-induced itch. Topically-applied strontium salts were previously found to be effective for reducing histamine-induced and IgE-mediated itch in humans. However, histamine is not considered the critical mediator in the majority of skin diseases presenting with chronic pruritus. The current study enrolled 32 healthy subjects in which itch was induced with cowhage before and after skin treatment with a gel containing 4% SrCl2, control vehicle, topical 1% hydrocortisone and topical 2% diphenhydramine. Strontium significantly reduced the peak intensity and duration of cowhage-induced itch when compared to the control itch curve, and was significantly superior to the other two over-the-counter antipruritic agents and its own vehicle in antipruritic effect. We hereby show that a 4% topical strontium formulation has a robust antipruritic effect, not only against histamine-mediated itch, but also for non-histaminergic pruritus induced via the PAR2 pathway, using cowhage.

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Section: Discussionmentioning

confidence: 95%

A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

Papoiu¹,

Valdés‐Rodríguez²,

Nattkemper³

et al. 2013

Acta Derm Venerol

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“…The neuronal function of CaSR is largely unknown. Recent studies indicate that activated CaSR stimulates dendritic growth in neurons (Vizard et al, 2008) and suppresses synaptic transmission (Chen et al, 2010; Phillips et al, 2008; Smith et al, 2004). Several CaSR mutations in patients have been found to associate with seizure.…”

Section: Cellular Functions Of the Nalcn Channel Complexmentioning

confidence: 99%

Sodium Leak Channels in Neuronal Excitability and Rhythmic Behaviors

Ren

2011

Neuron

136

139

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Extracellular K+, Na+, and Ca2+ ions all influence the resting membrane potential of the neuron. However, the mechanisms by which extracellular Na+ and Ca2+ regulate basal neuronal excitability are not well understood. Recent findings suggest that NALCN, in association with UNC79 and UNC80, contributes a basal Na+ leak conductance in neurons. Mutations in Nalcn, Unc79, or Unc80 lead to severe phenotypes that include neonatal lethality and disruption in rhythmic behaviors. This review discusses the properties of the NALCN complex, its regulation, and its contribution to neuronal function and animal behavior.

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“…The CaR is abundantly expressed in neurons and glia of the developing postnatal and adult nervous systems [147]. In the cortex, a presynaptic CaR modulates synaptic transmission as a function of increases in [Ca 2+ ] o in the synapse [103]. In other regions of the brain, the physiological role of the CaR has remained elusive [147].…”

Section: The Car and Developmentmentioning

confidence: 99%

Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR

Riccardi

Finney

Wilkinson

et al. 2009

Pflugers Arch - Eur J Physiol

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The capacity to sense and adapt to changes in environmental cues is of paramount importance for every living organism. From yeast to man, cells must be able to match cellular activities to growth environment and nutrient availability. Key to this process is the development of membrane-bound systems that can detect modifications in the extracellular environment and to translate these into biological responses. Evidence gathered over the last 15 years has demonstrated that many of these cell surface "sensors" belong to the G protein-coupled receptor superfamily. Crucial to our understanding of nutrient sensing in mammalian species has been the identification of the extracellular Ca(2+)/cation-sensing receptor, CaR. CaR was the first ion-sensing molecule identified in man and genetic studies in humans have revealed the importance of the CaR in mineral ion metabolism. Latter, it has become apparent that the CaR also plays an important role outside the Ca(2+) homeostatic system, as an integrator of multiple environmental signals for the regulation of many vital cellular processes, from cell-to-cell communication to secretion and cell survival/cell death. Recently, novel aspects of receptor function reveal an unexpected role for the CaR in the regulation of growth and development in utero.

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Calcium-Sensing Receptor Activation Depresses Synaptic Transmission

Cited by 56 publications

References 52 publications

A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

A Novel Topical Formulation Containing Strontium Chloride Significantly Reduces the Intensity and Duration of Cowhage-Induced Itch

Sodium Leak Channels in Neuronal Excitability and Rhythmic Behaviors

Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR

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