Calcium restriction during lactation has minimal effects on post-weaning mineral metabolism and bone recovery

Ross, Ryan D.; Meagher, Matthew J.; Sumner, Dale R.

doi:10.1007/s00774-018-0969-1

Cited by 5 publications

(11 citation statements)

References 49 publications

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“…cement lines, reflecting former eroded surfaces, were more deeply buried at 7 days compared with 1 day. Consistent with our previous publications in the lactation/low Ca model, (1,2) high-resolution μCT analysis at the distal femoral diaphyseal cortical bone showed relatively low cortical area and high cortical porosity levels at the end of weaning ( Fig. 3).…”

Section: Resultssupporting

confidence: 91%

“…The distal femoral diaphysis of the left femur was used for μCT and for Fourier transform infrared imaging (FTIR). Finally, the proximal metaphysis from femurs collected in a previously published study using the lactation/low calcium model (1) was used to evaluate remodeling histologically JBMR Plus (WOA) n 2 ROSS ET AL.…”

Section: Fluorochrome Labelingmentioning

confidence: 99%

“…Using small animal models, one can induce remodeling and synchronize the formation phase making the process of matrix mineralization in the adult skeleton more amenable to study. To this end, our lab has shown in adult rats that the bone formation phase is synchronized at multiple remodeling sites following a regimen in which a low calcium diet during lactation is followed by return to normal calcium intake upon weaning . The model is characterized by normal matrix mineralization kinetics and minimal effects on mineral metabolism during the formation period …”

Section: Introductionmentioning

confidence: 99%

“…To this end, our lab has shown in adult rats that the bone formation phase is synchronized at multiple remodeling sites following a regimen in which a low calcium diet during lactation is followed by return to normal calcium intake upon weaning. (1,2) The model is characterized by normal matrix mineralization kinetics (2) and minimal effects on mineral metabolism during the formation period. (1) Osteoporosis drugs alter bone mass by either inhibiting bone resorption or increasing bone formation.…”

Section: Introductionmentioning

confidence: 99%

“…(1,2) The model is characterized by normal matrix mineralization kinetics (2) and minimal effects on mineral metabolism during the formation period. (1) Osteoporosis drugs alter bone mass by either inhibiting bone resorption or increasing bone formation. (3,4) Although the effects of these treatments on resorption and formation are generally well-established by preclinical studies and clinical trials in which bone biopsies are analyzed, it is less common for researchers to investigate treatment effects on matrix maturation and the quality of the resulting matrix.…”

Section: Introductionmentioning

confidence: 99%

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Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

et al. 2020

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To test how osteoporosis drugs affect bone matrix maturation during cortical bone remodeling, 72 pregnant rats were switched from a 0.4% to a 0.01% calcium diet at parturition for a 23‐day lactation period. At weaning, eight dams were sacrificed to establish baseline values, while the remaining dams were returned to 0.4% calcium and treated with vehicle (saline), sodium fluoride (NaF), zoledronic acid (ZA), or sclerostin antibody (Scl‐Ab) for either 7 or 28 days (eight animals per group per time point). Femora were examined by μCT, dynamic histomorphometry, Fourier transform infrared imaging, and three‐point bending of notched specimens. Cortical porosity decreased in all groups from baseline to day 28. Intracortical mineralizing surface (MS/BS) and mineral apposition rate (MAR), as well as the mineral‐to‐matrix ratio were unaffected by treatment, but intracortical crystallinity was increased in the ZA group at day 10 compared with vehicle. Cortical area increased in all groups over 28 days mainly because of an addition of bone at the endocortical surface. Endocortical MS/BS did not vary among the groups, but endocortical MAR was suppressed in the NaF group at day 2 and elevated in the Scl‐Ab group at day 4 compared with vehicle. Endocortical mineral‐to‐matrix ratio was increased at days 5 and 10 following NaF treatment and endocortical crystallinity was increased at day 5 following ZA treatment compared with vehicle. Fracture toughness did not differ among the groups. Thus, the treatments affected matrix maturation more strongly at the endocortical then intracortical envelope. In this model of induced remodeling, the bone formation phase is synchronized at multiple sites, facilitating study of the effects of drugs or other bone‐targeting agents on matrix maturation independent of their effects on the initiation of remodeling. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

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Section: Resultssupporting

confidence: 91%

Section: Fluorochrome Labelingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

et al. 2020

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Mechanical Regulation of the Maternal Skeleton during Reproduction and Lactation

Liu

Wang

Bakker

et al. 2019

Curr Osteoporos Rep

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Purpose of review: This review summarizes recently published data on the effects of pregnancy and lactation on bone structure, mechanical properties, and mechano-responsiveness in an effort to elucidate how the balance between the structural and metabolic functions of the skeleton is achieved during these physiological processes. Recent findings: While pregnancy and lactation induce significant changes in bone density and structure to provide calcium for fetal/infant growth, the maternal physiology also comprises several innate compensatory mechanisms that allow for the maintenance of skeletal mechanical integrity. Both clinical and animal studies suggest that pregnancy and lactation lead to adaptations in cortical bone structure to allow for rapid calcium release from the trabecular compartment while maintaining whole-bone stiffness and strength. Moreover, extents of lactation-induced bone loss and weaning-induced recovery are highly dependent on a given bone's load-bearing function, resulting in better protection of the mechanical integrity at critical load-bearing sites. The recent discovery of lactation-induced osteocytic peri-lacunar/canalicular remodeling (PLR) indicates a new means for osteocytes to modulate mineral homeostasis and tissue-level mechanical properties of the maternal skeleton. Furthermore, lactation-induced PLR may also play an important role in maintaining the maternal skeleton's load-bearing capacity by altering osteocyte's microenvironment and modulating the transmission of anabolic mechanical signals to osteocytes.

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Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery

Bakker

Lai

et al. 2021

Bone

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Calcium restriction during lactation has minimal effects on post-weaning mineral metabolism and bone recovery

Cited by 5 publications

References 49 publications

Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling

Mechanical Regulation of the Maternal Skeleton during Reproduction and Lactation

Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery

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