Calcium-responsive order-to-order transitions by repetitive bacterial proteins
Marina Chang,
Winnie Huang,
Gatha Shambharkar
et al.
Abstract:Protein sequences dictate their functions, and sequence repetition is a common strategy to amplify function within modular, protein-based biomaterials and biotechnologies. Repetitive bacterial proteins have drawn interest for their calcium-responsive folding behavior, which stems from tandem repeats of the nonapeptide GGXGXDXUX in which X can be any amino acid and U is a hydrophobic amino acid. To determine the functional range of this nonapeptide, we modified a bacterial protein that forms β-roll structures i… Show more
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