Calcium remodeling in colorectal cancer

Alonso, Carlos; Sobradillo, Diego; Hernández-Morales, Miriam; Núñez, Lucı́a

doi:10.1016/j.bbamcr.2017.01.005

Cited by 48 publications

(44 citation statements)

References 62 publications

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“…TRPM8 regulates the motility of a variety of cancer cells including oral squamous carcinoma, lung cancer or prostate cancer cells [ 21 ], where its plasma membrane localization and tumorigenic potential are regulated by TRP channel-associated factors [ 22 ]. Studies concerning TRPC subfamily members have mainly focused on TRPC1, whose involvement in tumorigenesis varies depending on the stage and type of cancer considered [ 21 , 23 ]. TRPC6 has been reported to play a relevant role in the proliferation of gastric [ 24 ], prostate [ 25 ], esophageal squamous cell carcinoma [ 26 ] and hepatome cells [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

Jardín

Diez-Bello

López

et al. 2018

Cancers

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Transient receptor potential channels convey signaling information from a number of stimuli to a wide variety of cellular functions, mainly by inducing changes in cytosolic Ca2+ concentration. Different members of the TRPC, TRPM and TRPV subfamilies have been reported to play a role in tumorigenesis. Here we show that the estrogen receptor positive and triple negative breast cancer cell lines, MCF7 and MDA-MB-231, respectively, exhibit enhanced expression of the TRPC6 channel as compared to the non-tumoral MCF10A cell line. In vitro TRPC6 knockdown using shRNA impaired MCF7 and MDA-MB-231 cell proliferation, migration and invasion detected by BrdU incorporation, wound healing and Boyden chamber assays, respectively. Using RNAi-mediated TRPC6 silencing as well as overexpression of the pore-dead dominant-negative TRPC6 mutant we have found that TRPC6 plays a relevant role in the activation of store-operated Ca2+ entry in the breast cancer cell lines but not in non-tumoral breast cells. Finally, we have found that TRPC6 interacts with Orai1 and Orai3 in MCF7 and MDA-MB-231 cells and is required for the translocation of Orai1 and Orai3 to the plasma membrane in MDA-MB-231 and MCF7 cells, respectively, upon Ca2+ store depletion. These findings introduce a novel mechanism for the modulation of Ca2+ influx and the development of different cancer hallmarks in breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

Jardín

Diez-Bello

López

et al. 2018

Cancers

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“…As regards secondary tumourigenesis, both increased and decreased VGPC activity could promote the metastatic phenotype by promoting (i) accumulation of mutations and/or (ii) the VGSC activity itself, respectively. In addition, we should note that there is also evidence for major remodeling of Ca 2+ signaling in CRC but this is outside the scope of the present review [159,160].…”

Section: P53 Pathway In Colorectal Cancermentioning

confidence: 86%

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

Farooqı

Djamgoz

Siddik

2019

Seminars in Cancer Biology

111

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Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from decades of research, it seems clear that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. Highthroughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/β-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer. Introduction: Colorectal cancer is the 3 rd commonest cancer and the 2 nd leading cause of cancer-related deaths in the Western world (1). The outlook for disease incidence rates is bleak, reports predict up to a 60% rise in the global burden of CRC in developing countries by 2030 (2). Innovations in disease management are critical. Serine-20, may be less effective at mediating p53-dependent antitumor effects in these specific colorectal cancer patients. To our knowledge, such an investigation has not been reported as yet. Voltage-gated ion (sodium) channel expression in colorectal cancer: The bioelectricity of cancer cells generally differs from normal cells in several different respects [147]. In particular, increasing evidence suggest that a variety of ion channels, including voltage-gated ion channels, play a significant, dynamic role in the pathophysiology of cancer, including CRC [148]. Virtually all types of ion channel are involved, contributing to different components / stages of the cancer process. These include voltage-gated Na + , K +, Ca 2+ and Clchannels, ligand-gated ion channels and 'transient receptor potential' (Trp) channels [148]. Thus, cancer may even be regarded as a 'channelopathy' [148]. Here we focus on ion channels involved in metastasis since this is the main cause of death from cancer including CRC. In this regard, it is that has received the most attention [149]. According to the "Celex Hypothesis", acquisition of metastatic potential in cancer cells involves upregulation of functional voltage-gated Na + channels (VGSCs) activity and concomitant downregulation of outward currents, driven at least in part by voltage-gated K + channels (VGPCs) [150]. Overall, the possible electrical 'excitability' could form the basis of aggressive cancer cell behavior [150]. Membrane and protease genes Wnt signaling MAPK signaling Calcium signaling Membrane remodelling or secretion SCN5A Tumor cell invasion

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“…Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related death worldwide. 1 The incidence is higher in western countries and Japan; it is low in African and Middle East countries. 2 Although the Kingdom of Saudi Arabia (KSA) is considered a low-incidence area for CRC, the disease ranks second, after breast cancer, constituting almost nine percent of the newly diagnosed cases, ranking first and third among the male and female population, respectively.…”

Section: Introductionmentioning

confidence: 99%

Non-medical university students are not more knowledgeable than general population concerning serious diseases

Elshambaty

Gismalla

Alomari³

et al. 2018

Int J Community Med Public Health

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Background: The aim of this study was to know the level of awareness of non-medical university students of risk factors and symptoms of colorectal cancer.Methods: This is a cross-sectional study conducted at Al Baha University among non-medical students between 1st of May and 30th of June 2017.Results: The study comprised (n=463) students. Smoking and sedentary life as risk factors to CRC was known by (55.3%) and (51.0%) respectively. less than half (42%) knew that alcohol is a risk factor. The vast majority of our students (68.7%) had known that fruits and vegetables can decrease the incidence of CRC. The symptoms of CRC that more recognized by participants were abdominal pain (43.2%) and bleeding per rectum(45.5%).Conclusions: We concluded that the overall knowledge of non-medical University students concerning the awareness of risk factors and symptomatology of colorectal cancer is poor and nearly similar to general population knowledge concerning this problem.

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Calcium remodeling in colorectal cancer

Cited by 48 publications

References 62 publications

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure

Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights

Non-medical university students are not more knowledgeable than general population concerning serious diseases

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