Calcium regulation and Alzheimer's disease

Rapaka, Deepthi; Bitra, Veera Raghavulu; Medapati, Jayaram Reddy; Akula, Annapurna

doi:10.1016/s2222-1808(14)60666-6

Cited by 14 publications

(8 citation statements)

References 60 publications

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“…Even though the brain accounts for less than 2% of the bodyweight, it consumes 20% of the basal oxygen up take [20]. Lipid peroxidation is well recognized mechanism of cellular injury in biological system of plants and animals.…”

Section: Discussionmentioning

confidence: 99%

Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory

Rapaka

Bitra

Vishala

et al. 2019

Journal of Ayurveda and Integrative Medicine

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BackgroundAluminum a known neuro and cholinotoxin has been implicated in the pathogenesis of Alzheimer’s disease. Its exposure is associated with impairment of the memory and cognition.ObjectiveThe present study was undertaken to evaluate the anti-Alzheimer’s activity of Vitis vinifera in aluminum induced Alzheimer’s disease.Materials and methodsIn this study, we investigated the behavioral and biochemical effects of aluminum in Sprague-Dawley rats. Animals were exposed to aluminum chloride (100 mg/kg/day) orally for a period of 8 weeks. Vitis was given in doses of 250 mg/kg and 500 mg/kg for 16 weeks and the possible effects of Vitis vinifera on the expression of Tau and amyloid precursor protein were evaluated by PCR analysis and the possible activities of lipid peroxidation, inflammation and anti-cholinesterase activity were evaluated.ResultsAluminum intoxication was associated with significant impairment in learning and memory in Morris water maze test. A significant improvement was observed with Vitis vinifera in a dose dependent manner.ConclusionThe findings of the present study revealed the significant neuroprotective actions of Vitis vinifera by modifying the biochemical parameters and inhibited the mRNA expression of Amyloid Precursor Protein and Tau, which are the key pathological hallmarks of Alzheimer’s disease, which was further confirmed by histopathological observations.

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Section: Discussionmentioning

confidence: 99%

Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory

Rapaka

Bitra

Vishala

et al. 2019

Journal of Ayurveda and Integrative Medicine

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“…It inhibits caspase activation [71] and blockade of glutamate leads to elevated Ca 2+ . This elevation of calcium leads to neurotoxicity [72] , due to activation of proteases, lipases, and nitric oxide synthases, thereby increasing free radical formation. It also increases glucose metabolism and induces heat shock protein and necrotic cell death in neurons [70 , 71] .…”

Section: Methods Detailsmentioning

confidence: 99%

Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease

2022

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“…ER along with mitochondria serves as a principal intracellular store for calcium release and storage (Rapaka et al, 2014). ER calcium homeostasis aims at maintaining Ca +2 concentrations in the cytosol and the ER lumen at their optimal levels.…”

Section: Regulation Of Calcium Homeostasis Under Normal Physiological...mentioning

confidence: 99%

Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications

Joshi

Khambete

et al. 2022

Chem Biol Drug Des

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Calcium regulation and Alzheimer's disease

Cited by 14 publications

References 60 publications

Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory

Vitis vinifera acts as anti-Alzheimer's agent by modulating biochemical parameters implicated in cognition and memory

Experimentally induced animal models for cognitive dysfunction and Alzheimer's disease

Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications

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