Calcium pyrophosphate dihydrate deposition in degenerate lumbar discs

Berlemann, U.; Gries, N. C.; Moore, Robert J.; Fraser, Robert D.; Vernon‐Roberts, B.

doi:10.1007/s005860050026

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…As previously indicated, CPPD deposition in the lumbar intervertebral disc is usually asymptomatic, and can occur in the absence of the clinical or radiographical features in other joints or associated systemic diseases, as in our patient (3, 5, 12). The clinical manifestations associated with the lumbar spine can occur without radiographical abnormalities on simple X-rays, as in our patient (5, 13).…”

Section: Discussionsupporting

confidence: 71%

“…Mohr et al (11) suggested that CPPD deposition is an age-related phenomenon because there is an increased frequency of crystalline deposits with increasing age. Furthermore, in a study of Berleman et al (12) with discs obtained during ALIF for severe discogenic pain, no differences were found in clinical features between patients with and without CPPD deposition.…”

Section: Discussionmentioning

confidence: 86%

“…From the results of the autopsy of 6 hemochromatosis patients with no pain or stiffness of the spine, CPPD deposition was found in 4 patients with degenerated disc (9). CPPD deposition was found in 3.1% to 12.6% of discs excised surgically in case of herniation or obtained from patients undergoing anterior lumbar interbody fusion (ALIF) (3, 10-12). Mohr et al (11) suggested that CPPD deposition is an age-related phenomenon because there is an increased frequency of crystalline deposits with increasing age.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical manifestations associated with the lumbar spine can occur without radiographical abnormalities on simple X-rays, as in our patient (5, 13). The role of surgery or trauma to the intervertebral disc has been suggested in CPPD deposition in the lumbar disc (3, 12-14). In Andres and Trainer's study (3), the significant common factor in all 7 patients with CPPD deposition in the intervertebral disc was a previous disc surgery at the same level, except one at adjacent level.…”

Section: Discussionmentioning

confidence: 99%

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Cauda Equina Syndrome Caused by Pseudogout Involving the Lumbar Intervertebral Disc

2012

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Calcium pyrophosphate dihydrate (CPPD) deposition disease, also known as pseudogout, is a disease that causes inflammatory arthropathy in peripheral joints, however, symptomatic involvement of the intervertebral disc is uncommon. Herein, we describe a 59-yr-old patient who presented with cauda equina syndrome. Magnetic resonance imaging of the patient showed an epidural mass-like lesion at the disc space of L4-L5, which was compressing the thecal sac. Biopsy of the intervertebral disc and epidural mass-like lesion was determined to be CPPD deposits. We reviewed previously reported cases of pseudogout involving the lumbar intervertebral disc and discuss the pathogenesis and treatment of the disease.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cauda Equina Syndrome Caused by Pseudogout Involving the Lumbar Intervertebral Disc

2012

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“…In the other study, the clinical significance of CPPD deposition in degenerate lumbar discs was evaluated using 103 discs from 70 patients with advanced degenerative disc disease [6]. The patients were younger than the typical patient population for pseudogout.…”

Section: Clinical Correlatesmentioning

confidence: 99%

Crystal-induced inflammatio and cartilage degradation

McCarthy

1999

Curr Rheumatol Rep

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In the past year, there have been advances in our understanding of the induction of cartilage damage by calcium-containing crystals. Mechanisms of deposition and the biologic effects of crystals have been further characterized, as has the interaction between crystals and leukocytes. Studies of the clinical diagnosis of crystal deposition diseases suggest that accuracy with microscopy needs to be enhanced. Normal values for serum NTPPPHase have been established and optimal diagnostic imaging strategies for calcium pyrophosphate deposition disease have been suggested. There are still no available drugs to inhibit deposition or effect reabsorption of calcium-containing crystals.

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