Calcium Pyrophosphate Deposition Disease of the Temporal Bone

Jordan, Jennifer A.; Lindberg, Guy; Roland, Peter S.; Mendelsohn, Dianne B.

doi:10.1177/000348949810701103

Cited by 23 publications

(21 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Speziell bei Befall des Kiefergelenks kommt es häufig zur Ausbildung von Pseudotumoren [5], welche klinisch als Raumforderungen der Glandula parotis erscheinen.Radiologisch und histologisch wird nicht selten zunächst die Fehldiagnose eines malignen mesenchymalen Tumors mit entsprechenden Konsequenzen für den Patienten gestellt.…”

Section: Kalziumpyrophosphatarthropathie Des Kiefergelenksunclassified

“…Die Erkrankung betrifft meist ältere Patienten und überwiegend Frauen [5].Sie zeigt eine pathogenetisch nicht geklärte Prädilekti-on für Faserknorpel, wie er sich auch in Diskus und Gelenkknorpel des Kiefergelenks findet [2]. Dennoch stellt der Befall dieses Gelenks eine Seltenheit dar.…”

Section: Diskussionunclassified

“…Klinisch treten bei Befall des Kiefergelenks am häufigsten Schmerzen,aber auch Schwellungen der präaurikulären Region und die Ausbildung einer Kieferklemme auf [5].Vereinzelt werden jedoch, wie im vorliegenden Fall, auch Ohrbeschwerden im Sinne von Hörminderungen und Otalgien als Erstsymptome angegeben [5,8]. Die Hörminderung erklärt sich entweder durch eine Verlegung des Gehörganges oder der Tuba auditiva mit konsekutiver Schalleitungsschwerhörigkeit.…”

Section: Diskussionunclassified

See 2 more Smart Citations

Kalziumpyrophosphat-Arthropathie des Kiefergelenks

Koitschev

Kaiserling

Koitschev

2003

HNO

View full text Add to dashboard Cite

Calcium pyrophosphate dihydrate deposition disease (CPPD) of the temporomandibular joint is rare. The disorder is characterized by the presence of crystal deposits within the affected joint. The deposition of crystals in adjacent soft tissue may lead to the formation of pseudotumors. This form of the disease is called tophaceous pseudogout and typically affects the temporomandibular joint. It is difficult to differentiate the disease, particularly from malignant tumors, on the clinical and radiographic findings alone. The diagnosis is based on histological identification of the calcium pyrophosphate crystals. We present an unusually advanced case of tophaceous pseudogout of the temporomandibular joint. The etiology, clinical and diagnostic criteria as well as treatment options are discussed on the basis of our own experience and a review of the literature.

show abstract

Section: Kalziumpyrophosphatarthropathie Des Kiefergelenksunclassified

Section: Diskussionunclassified

See 1 more Smart Citation

Kalziumpyrophosphat-Arthropathie des Kiefergelenks

Koitschev

Kaiserling

Koitschev

2003

HNO

View full text Add to dashboard Cite

show abstract

“…Pyrophosphate tophaceous or pseudotumoral deposits occur primarily in the knees, hips, elbow, and temporal mandibular joint [59,60]. Tophi are also seen in the DIPs, MCPs, acromio-clavicular joints, and less often in bursae and periarticular tissues [2,3].…”

Section: Atypical Presentationsmentioning

confidence: 99%

“…Tophi are also seen in the DIPs, MCPs, acromio-clavicular joints, and less often in bursae and periarticular tissues [2,3]. Cases have also been described with pseudotumors affecting the temporal bone and hip joint [60,61], presenting as pseudotumors, an very rarely as sclerochoroidal calcification [62]. A wris tenosynovitis can occur as an acute or chronic form which results in a carpal tunnel and cubital tunnel syndrome or even tendon rupture [63,65].…”

Section: Atypical Presentationsmentioning

confidence: 99%

Familial and clinical aspects of calcium pyrophosphate deposition diseas

1999

View full text Add to dashboard Cite

The mechanisms involved in calcium pyrophosphate dehydrated deposition disease (CPPDD) are unknown and those families with the disease, described in different countries, provide a fertile file for genomic research. Genomic DNA studies in these kindred with secondary or primary form of CPPDD provide a shortcut for trying to investigate the biomolecular basis of the disease. Mutations in the COL2A1 gene have been identified in one family with spondyloepiphyseal dysplasia and secondary deposits of pyrophosphate and apatite crystalline deposits. In another kindred with CPPDD due to precocious osteoarthritis, the phenotype was linked to markers of chromosome 8p. In four other kindreds (British, Argentinean, French, and the United States), the phenotypes were linked to a precise region of chromosome 5p. Two possible genes located in this region that are expressed in the articular cartilage, but of unknown articular physiologic role are being investigated as possible CPPDD genes. From the clinical point of view, CPPDD spectrum of clinical and radiographic manifestations is enlarging, especially those related to spine involvement or pseudo tumoral forms. At the end, the present review of a current therapeutic approach for CPPDD is discussed.

show abstract