Calcium Prevents Enhanced Degradation of Factor VIII in the Condition of Motion
Haim Cohen,
Anat Keren-Politansky,
Yonatan Crispel
et al.
Abstract:Background: Hemophilia A and B induce recurrent bleeding episodes, mainly in skeletal muscles and joints that are in intermittent motion. We have previously demonstrated that intermittent motion contributes to increased degradation of factors VIII and IX. Objectives: Given that calcium ions are known to enhance factor VIII–von Willebrand factor (vWF) interaction, the present study has investigated the role of these ions on factors VIII and IX in the condition of motion. Methods: The effects of calcium ions wer… Show more
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