Calcium polyphosphate precipitation – A strategy to tune the chain length of the glass and control the subsequent release of vancomycin

Comeau, Patricia; Filiaggi, Mark

doi:10.1016/j.matchemphys.2015.03.050

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…Preparation and characterization of MPP . MPP was prepared using sodium polyphosphate (SPP) aqueous solution by following the method described by Comeau et al 29 First, Na 2 HPO 4 ·2H 2 O was heated at 800 °C in a box muffle furnace for 20 hours, then quenched in air, and cooled to 25 °C, where a linear SPP was obtained. Next, a 20% (w/v) MgCl 2 aqueous solution was added dropwise to a 2% (w/v) SPP aqueous solution to form a MPP coacervate.…”

Section: Methodsmentioning

confidence: 99%

Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

et al. 2022

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Section: Methodsmentioning

confidence: 99%

Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

et al. 2022

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“…CPP was fabricated using sodium dihydrogen phosphate dehydrate (Chengdu Kelong Chemical Co. Ltd, Chengdu, China) in the laboratory. 43 Briefly, sodium dihydrogen phosphate dehydrate was heated in a corundum crucible at 800 C for 20 h to obtain sodium polyphosphate. Next, a 10% (w/v) aqueous solution of CaCl 2 was added in a 2% (w/v) aqueous solution of sodium polyphosphate to form CPP gel; the CPP gel was then subsequently freeze dried to form an amorphous powder.…”

Section: Methodsmentioning

confidence: 99%

“…As an inorganic macromolecule, the chain length of CPP is an important characteristic. 31 P-NMR of CPP was conducted, as shown in Figure 3(a). The 31 P-NMR spectrum of the as-prepared CPP powder indicated that the CPP was a long-chain polyphosphate structure, and an internal phosphate peak suggested a predominant linear polyphosphate structure.…”

Section: Component and Morphology Characterizationmentioning

confidence: 99%

“…[25][26][27] Simultaneously, PVA increases the degradation of bone cement and hardly affects the hydration reaction, 28 calcium polyphosphate (CPP) is employed to promote the bioactivity of materials. In polyphosphate molecules, phosphate tetrahedrons are linked by oxygen bridges, with each bridging oxygen atom being shared by two tetrahedra and a calcium to phosphorus ratio of 0.5, [29][30][31] its chain structure leads to a much higher mechanical strength than that of other calcium phosphates. 32 Polyphosphate is widely found in the osteoblasts and platelets of mammals and plays a role in storing phosphate in vivo.…”

Section: Introductionmentioning

confidence: 99%

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A novel degradable tricalcium silicate/calcium polyphosphate/polyvinyl alcohol organic-inorganic composite cement for bone filling

Zhang

Chen

et al. 2021

J Biomater Appl

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In this study, tricalcium silicate (C3S) calcium/polyphosphate/polyvinyl alcohol organic-inorganic self-setting composites were successfully designed. A variety of tests were conducted to characterize their self-setting properties, mechanical properties, degradation properties, and related biological properties. The composite bone cements showed a short setting time (5.5–37.5 min) with a 5:5–6:4 ratio of C3S/CPP to maintain a stable compressive strength (28 MPa). In addition, PVA effectively reduced the brittleness of the inorganic phase. Degradation experiments confirmed the sustainable surface degradation of bone cement. A maximum degradation rate of 49% was reached within 56 days, and the structure remained intact without collapse. Culturing MC3T3 cells with bone cement extracts revealed that the composite bone cements had excellent biological properties in vitro. The original extract showed a proliferation promotion effect on cells, whereas most of the other original extracts of degradable bone cements were toxic to the cells. Meanwhile, extracellular matrix mineralization and alkaline phosphatase expression showed remarkable effects on cell differentiation. In addition, a good level of adhesion of cells to the surfaces of materials was observed. Taken together, these results indicate that C3S/CPP/PVA composite bone cements have great potential in bone defect filling for fast curing.

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“…15 As another calcium phosphate-based bio-ceramic with similar chemical structure of HA, CPP has been designed as scaffolds for bone repair and regeneration because of its appropriate mechanical performance, excellent biocompatibility, and recognized osteo-conductivity. [16][17][18][19] CPP has an inductive effect on the growth of osteoblast cells because the energy produced by the breakage of P-O-P bonds between [PO 3 ] units can accelerate the breaking of high-energy anhydride linkages of the adenosine triphosphate. 20 Müller et al 21 have indicated that bioactivity of alkaline phosphatase expression of CPP was even prior to HA and β-TCP by investigating in vitro cellular responses of SaOS-2 cells.…”

Section: Introductionmentioning

confidence: 99%

Bioactive poly(etheretherketone) composite containing calcium polyphosphate and multi-walled carbon nanotubes for bone repair: Mechanical property and in vitro biocompatibility

Cao

Chen

et al. 2018

Journal of Bioactive and Compatible Polymers

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Poly(etheretherketone) exhibits good biocompatibility, excellent mechanical properties, and bone-like stiffness. However, the natural bio-inertness of pure poly(etheretherketone) hinders its applications in biomedical field, especially when direct bone-implant osteo-integration is desired. For developing an alternative biomaterial for load-bearing orthopedic application, combination of bioactive fillers with poly(etheretherketone) matrix is a feasible approach. In this study, a bioactive multi-walled carbon nanotubes/calcium polyphosphate/poly(etheretherketone) composite was prepared through a compounding and injection-molding process for the first time. Bioactive calcium polyphosphate was added to polymer matrix to enhance the bioactivity of the composite, and incorporation of multi-walled carbon nanotubes to composite was aimed to improve both the mechanical property and biocompatibility. Furthermore, the microstructures, surface hydrophilicity, and mechanical property of multi-walled carbon nanotubes/calcium polyphosphate/ poly(etheretherketone) composite, as well as the cellular responses of MC3T3-E1 osteoblast cells to this material were investigated. The mechanical testing revealed that mechanical performance of the resulting ternary composite was significantly enhanced by adding the multi-walled carbon nanotubes and the mechanical values obtained were close to or higher than those of human

show abstract

Calcium polyphosphate precipitation – A strategy to tune the chain length of the glass and control the subsequent release of vancomycin

Cited by 6 publications

References 48 publications

Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

A novel degradable tricalcium silicate/calcium polyphosphate/polyvinyl alcohol organic-inorganic composite cement for bone filling

Bioactive poly(etheretherketone) composite containing calcium polyphosphate and multi-walled carbon nanotubes for bone repair: Mechanical property and in vitro biocompatibility

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