Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond

Anghel, Lucreția; Manole, Corina; Nechita, Aurel; Tatu, Alin Laurențiu; Ștefănescu, Bogdan Ioan; Nechita, Luiza; Bușilă, Camelia; Zainea, Pușica; Baroiu, Liliana; Mușat, Carmina Liana

doi:10.3390/biomedicines11092362

Biomedicines

2023

DOI: 10.3390/biomedicines11092362

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Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond

Lucreția Anghel,

Corina Manole,

Aurel Nechita

et al.

Abstract: The coronavirus disease (COVID-19) pandemic caused by the novel coronavirus SARS-CoV-2 has had a profound impact on global health, leading to a surge in research to better understand the pathophysiology of the disease. Among the various aspects under investigation, disruptions in mineral homeostasis have emerged as a critical area of interest. This review aims to provide an overview of the current evidence linking calcium, phosphorus and magnesium abnormalities with COVID-19 infection and explores the potentia… Show more

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2024

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Cited by 3 publications

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Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

Kumar,

Japa,

Tomo

et al. 2024

Ind J Clin Biochem

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Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

Kumar,

Japa,

Tomo

et al. 2024

Ind J Clin Biochem

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The association between serum phosphate and length of hospital stay and all-cause mortality in adult patients: a cross-sectional study

Zhou,

Zhang,

Chen

et al. 2024

Nutr J

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Background Data is limited on the prevalence of hypophosphatemia in general hospitalized patients, and its association with length of hospital stay (LOS) and mortality remained unclear. We aimed to investigate the prevalence of admission phosphate abnormality and the association between serum phosphate level and length of hospital stay and all-cause mortality in adult patients. Methods This was a multi-center retrospective study based on real-world data. Participants were classified into five groups according to serum phosphate level (inorganic phosphorus, iP) within 48 h after admission: G1, iP < 0.64 mmol/L; G2, iP 0.64–0.8 mmol/L; G3, iP 0.8–1.16 mmol/L; G4, iP 1.16–1.45 mmol/L; and G5, iP ≥ 1.45 mmol/L, respectively. Both LOS and in-hospital mortality were considered as outcomes. Clinical information, including age, sex, primary diagnosis, co-morbidity, and phosphate-metabolism related parameters, were also abstracted from medical records. Results A total number of 23,479 adult patients (14,073 males and 9,406 females, aged 57.7 ± 16.8 y) were included in the study. The prevalence of hypophosphatemia was 4.74%. An “L-shaped” non-linear association was determined between serum phosphate level and LOS and the inflection point was 1.16 mmol/L in serum phosphate level. Compared with patients in G4, patients in G1, G2 or G3 were significantly associated with longer LOS after full adjustment of covariates. Each 0.1 mmol/L decrease in serum phosphate level to the left side of the inflection point led to 0.64 days increase in LOS [95% confidence interval (CI): 0.46, 0.81; p for trend < 0.001]. But there was no association between serum phosphate and LOS where serum levels of phosphate ≥ 1.16 mmol/L. Multivariable logistic regression analysis showed that adjusted all-cause in-hospital mortality was 3.08-fold greater in patients in G1 than those in G4 (95% CI: 1.52, 6.25; p for trend = 0.001). Similarly, no significant association with either LOS or mortality were found in patients in G5, comparing with G4. Conclusions Hypophosphatemia, but not hyperphosphatemia, was associated with LOS and all-cause mortality in adult inpatients. It is meaningful to monitor serum levels of phosphate to facilitate early diagnosis and intervention.

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The Influence of the COVID-19 Pandemic on the Addressability to Treatment of Children with Hyperhidrosis—A Retrospective Study and a Short Review

Nastase,

Nicolescu,

Busila

et al. 2024

Life

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Introduction: This study was carried out to demonstrate the negative influence that the COVID-19 pandemic had on the ability of patients to treat hyperhidrosis with iontophoresis. The purpose of this study is to identify the annual distribution of patients with hyperhidrosis as well as elaborate a curve of cases within the time interval studied. Methods: It is a retrospective study initiated in the Department of Neuropsychomotor Rehabilitation of the “Sf. Ioan” Emergency Clinical Hospital for Children, Galati, Romania, in which we analyzed the electronic database, the treatment, and the consultation files of all the children who presented between January 2013 and December 2023. We found 111 patients who met the inclusion criteria. Results: During the 3 years of the pandemic, the number of patients who came to our clinic suddenly dropped to 0. Limitations: This study was conducted on a relatively small number of patients in a Neuropsychomotor Recovery clinic. This study includes only patients with palmar and/or plantar hyperhidrosis who presented to the clinic for iontophoresis. Conclusion: Although it is a disease that significantly influences the quality of life, patients and their families do not consider hyperhidrosis to be an urgent problem that can be improved by treatment.

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Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond

Cited by 3 publications

References 87 publications

Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP

The association between serum phosphate and length of hospital stay and all-cause mortality in adult patients: a cross-sectional study

The Influence of the COVID-19 Pandemic on the Addressability to Treatment of Children with Hyperhidrosis—A Retrospective Study and a Short Review

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