Calcium phosphates for biomedical applications

Canillas, María; Pena, P.; Aza, Antonio H. De; Rodríguez, Miguel Á.

doi:10.1016/j.bsecv.2017.05.001

Cited by 169 publications

(96 citation statements)

References 214 publications

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“…Although some authors mention the potential of sericin/CaP as scaffolds for TE (Takeuchi et al, 2003b;Yang et al, 2014b), an ideal 3D scaffold should not only act as a template for tissue growth and has controlled resorbability, but should also elicit a regenerative effect and present adequate mechanical performance over time (Canillas et al, 2017). As previously mentioned, the last requirement is not fulfilled by using only sericin (Ahsan et al, 2018).…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

“…Despite their properties of interest and numerous applications, sericin/CaP composites still have disadvantages to circumvent such as poor mechanical resistance under complex stress states. CaPs and pure sericin have a low mechanical profile when compared to bone tissue, which limits the application of sericin/CaP composites as 3D biomaterials for load-bearing applications (Kunz et al, 2016;Canillas et al, 2017). Of the reviewed papers, only Zhang et al (2014) reported the mechanical properties of sericin/HAp composites, obtained by mineralization of a flexible ethanol-treated sericin film.…”

Section: Recent Advancesmentioning

confidence: 99%

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Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

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Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its recovery after being associated with numerous biological properties such as antioxidant, antibacterial, anti-coagulation and regenerative activities. In the past years, sericin has also demonstrated to be suitable as a template for CaP mineralization. The present review focuses on the recent developments for the production of sericin/CaP composites, exploring their potential applications in bioengineering and opening new avenues in other research fields such as in the cosmetic, food and environmental sectors. In addition, this paper can also be useful as a guideline to design future research based on sericin/CaP biomaterials.

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Section: Bone Tissue Engineeringmentioning

confidence: 99%

Section: Recent Advancesmentioning

confidence: 99%

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

et al. 2020

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“…Both PHB and PHBV can be used as biomaterials due to their biocompatible and biodegradable nature. Likewise, the copolymer of PHBV can be used for biocomposite development with HA and tricalcium phosphate (TCP) as both have osteoconductive and resorbable properties . Chen et al reported the synthesis of HA/PHBV and TCP/PHBV composites by incorporating 30 vol% of HA and TCP in the biodegradable PHBV copolymer through compounding and compression molding.…”

Section: Phb Based Biocompositesmentioning

confidence: 99%

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Raza

Noor

Khalil

2019

Biotechnology Progress

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Poly(hydroxybutyrate) (PHB) has become an attractive biomaterial in research and development for past few years. It is natural bio‐based aliphatic polyester produced by many types of bacteria. Due to its biodegradable, biocompatible, and eco‐friendly nature, PHB can be used in line with bioactive species. However, high production cost, thermal instability, and poor mechanical properties limit its desirable applications. So there is need to incorporate PHB with other materials or biopolymers for the development of some novel PHB based biocomposites for value addition. Many attempts have been employed to incorporate PHB with other biomaterials (or biopolymers) to develop sustainable biocomposites. In this review, some recent developments in the synthesis of PHB based biocomposites and their biomedical, packaging and tissue engineering applications have been focused. The development of biodegradable PHB based biocomposites with improved mechanical properties could be used to overcome its native limitations hence to open new possibilities for industrial applications.

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“…Synthetic tricalcium phosphate (Ca 3 (PO 4 ) 2 ; TCP) granules and coatings have been successfully used for more than 40 years for bone repairing in dentistry, maxilla‐facial and trauma surgery. Well known properties of TCP materials are their biocompatibility, bioactivity, osteconductivity, and biodegradability (Canillas, Pena, De Aza, & Rodriguez, ; Hench, ; Hench & Wilson, ).…”

Section: Introductionmentioning

confidence: 99%

Diopside‐tricalcium phosphate bioactive ceramics for osteogenic differentiation of human adipose stem cells

et al. 2019

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Ti scaffolds combined with autologous human adipose‐derived mesenchymal stem cells (hASCs) have been successfully applied for regenerative cranio‐maxillofacial bone therapies. Future challenges reside in regeneration of larger bone defects and displacement of the permanent Ti structure, thus, advanced resorbable scaffolds are needed. Composites of β‐Ca3(PO4)2 with 80 and 60 wt % of CaMg(SiO3)2 with improved mechanical properties compared to tricalcium phosphate (TCP) materials are presented. Synthetic CaMg(SiO3)2 and a precursor of Ca3(PO4)2 were used to fabricate the composites and a reference β‐Ca3(PO4)2 material by uniaxial pressing and solid state sintering. Optimum sintering temperature of 1225°C was selected. Microstructural analysis and Weibull distributions of tensile strengths determined by the diametral compression of discs test are reported. Thermodynamic simulation of the dissolution process in simulated body fluid body fluid was done. The biological response with hASCs was analyzed using basic and osteogenic media. Viability and osteogenic potential—LIVE/DEAD assay; alkaline phosphatase activity and collagen type‐I production—were characterized. The composites have higher tensile strength (>3×) than TCP materials, for similar reliability, and support viability and osteogenic differentiation of hASCs. Resorption of the high strength phase diopside is the slowest. The promising results reported here suggest possible uses of these bioactive β‐Ca3(PO4)2–CaMg(SiO3)2 ceramics together with hASCs in bone tissue engineering.

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Calcium phosphates for biomedical applications

Cited by 169 publications

References 214 publications

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Recent Advances in Silk Sericin/Calcium Phosphate Biomaterials

Recent developments in the synthesis of poly(hydroxybutyrate) based biocomposites

Diopside‐tricalcium phosphate bioactive ceramics for osteogenic differentiation of human adipose stem cells

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