Calcium phosphate scaffold and bone marrow for bone reconstruction in irradiated area: a dog study

Malard, O.; Guicheux, Jérôme; Bouler, Jean‐Michel; Gauthier, Olivier; Montreuil, C Beauvillain de; Aguado, Eric; Pilet, Paul; LeGeros, Racquel Z.; Daculsi, Guy

doi:10.1016/j.bone.2004.07.018

Cited by 61 publications

(54 citation statements)

References 29 publications

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“…Histological examinations showed that bone reconstruction was in contact with BCP mostly after BCP-TBM mixture implantation. This observation confirmed that BCP maintains its properties of biocompatibility and osteoconductivity even after irradiation of the recipient site [6]. Histological and quantitative analyses of newbone formation showed a significant increase in bone repair with the BCP-TBM mixture.…”

Section: Discussionsupporting

confidence: 73%

“…This calcium phosphate biomaterial is commonly used for bone substitution without any previous irradiation and is commercially available in different forms (granules and blocks) [4]. Furthermore, a synergistic effect of BCP and TBM has been previously demonstrated in bone repair after irradiation in rats [6].…”

Section: Discussionmentioning

confidence: 98%

“…However, unlike non-irradiated bone, in which calcium phosphate appears to be clinically relevant to autogenous bone grafting [4], calcium phosphate alone is not sufficient to reconstruct bone in irradiated areas. Previous studies have shown that biphasic calcium phosphate (BCP) associated with total bone marrow (TBM) provides better bone reconstruction than TBM or BCP alone in irradiated bone [5,6].…”

Section: Introductionmentioning

confidence: 99%

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A comparison between bone reconstruction following the use of mesenchymal stem cells and total bone marrow in association with calcium phosphate scaffold in irradiated bone

et al. 2009

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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A comparison between bone reconstruction following the use of mesenchymal stem cells and total bone marrow in association with calcium phosphate scaffold in irradiated bone

et al. 2009

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“…Second, because of the autogenous properties, their application can avoid possible complications, such as immunogenic reactions and disease transmissions, which can come from allogenic or synthetic materials. Various experimental researches have shown considerable evidence of the efficacy of the use of autologous mononuclear cells from bone marrow in combination with various scaffolds in promoting bone formation in the area of bone defects [8,10,11,20,26,37]; however, there have been no studies evaluating these treatments in humans undergoing distraction osteogenesis. We found no difference in the external fixation index, but some benefits in terms of cortical consolidation that permitted earlier weightbearing in patients treated with BMAC plus PRP compared to patients who were not thus treated.…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Lee¹,

Ryu²,

Kim³

et al. 2014

Clin Orthop Relat Res

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Background During lower limb lengthening, poor bone regeneration is a devastating complication. Several local or systemic applications have been used to promote osteogenesis, and biologic stimulations are gaining attention, but their utility has not been proven in this setting. Questions/purposes In patients undergoing bilateral tibial lengthening, we compared those receiving an osteotomy site injection of autologous bone marrow aspirate concentrate (BMAC) plus platelet-rich plasma (PRP) with those not receiving such an injection in terms of external fixator index (time in external fixation divided by amount of lengthening), full weightbearing index (time until a patient was permitted to do full weightbearing divided by amount of lengthening), four cortical healing indexes (time until each cortical union divided by amount of lengthening), and callus shape and type. Methods Twenty-two patients (44 tibias) undergoing bilateral tibial lengthening enrolled in this randomized trial. Two patients were excluded, one due to insufficient radiographic evaluation and one who was lost to followup, leaving 20 patients (40 segments) for inclusion. Ten patients (20 segments) received BMAC combined with PRP injection (treatment group) and 10 patients (20 segments) received no injection (control group). All patients underwent stature lengthening for familial short stature with the lengthening over nail technique. Autologous BMAC combined with PRP was injected at the tibial osteotomy site at the end of the index surgery. Mean distraction rates were similar between groups (0.75 mm/day in the treatment group versus 0.72 mm/day in the control group; p = 0.24). Full weightbearing was permitted when we observed radiographic evidence of healing at two cortices; this assessment was made by the surgeon who was blinded to the treatment each patient received. Minimum followup was 24 months (mean, 28 months; range, 24-34 months).

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“…De plus, l'irradiation postopé ratoire le plus souvent né cessaire compromettrait le potentiel osté o-inducteur de ces biomaté riaux [72,73]. Pour pallier ces deux é cueils, des modè les expé rimentaux de reconstruction osseuse par cé ramique phosphocalcique puis greffe autologue de moelle osseuse aprè s irradiation ont é té ré cemment dé veloppé s [74][75][76]. Le sché ma associe successivement : reconstruction par biomaté riaux, irradiation, injection percutané e de moelle osseuse autologue.…”

Section: Ingénierie Tissulaireunclassified

Reconstruction mandibulaire en cancérologie : état actuel et perspectives

Jégoux

Bedfert

Alno

et al. 2009

Annales d'Otolaryngologie et de Chirurgie Cervico-faciale

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Calcium phosphate scaffold and bone marrow for bone reconstruction in irradiated area: a dog study

Cited by 61 publications

References 29 publications

A comparison between bone reconstruction following the use of mesenchymal stem cells and total bone marrow in association with calcium phosphate scaffold in irradiated bone

A comparison between bone reconstruction following the use of mesenchymal stem cells and total bone marrow in association with calcium phosphate scaffold in irradiated bone

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Reconstruction mandibulaire en cancérologie : état actuel et perspectives

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