Calcium phosphate formation on TiO2 nanomaterials of different dimensionality

Erceg, Ina; Selmani, Atiđa; Gajović, Andreja; Panžić, Ivana; Iveković, Damir; Faraguna, Fabio; Šegota, Suzana; Ćurlin, Marija; Strasser, Vida; Kontrec, Jasminka; Kralj, Damir; Maltar-Strmečki, Nadica; Sikirić, Maja Dutour

doi:10.1016/j.colsurfa.2020.124615

Cited by 10 publications

(27 citation statements)

References 68 publications

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“…had the most negative zeta potential among investigated TiNMs [13]. This indicates that, as shown by Uchida et.al., a specific arrangement of Ti-OH groups is also needed and it depends both on NMs composition and morphology [57].…”

Section: Tinpls and Tinws Characterizationsupporting

confidence: 73%

“…In our recent article, we have shown that by using precipitation systems with higher supersaturation than in c-SBF it is possible to coat TiNPs and TiNTs with CaDHA [13]. To the best of our knowledge, no Although TiNPls and TiNWs showed a low ability to induce CaP formation in SBF, as well as TiNPs and TiNTs investigated in a previous study [13], some trends in the influence of morphology and surface structure of TiNMs could be observed. The key step in CaPs' formation on titanium is the presence of Ti-OH groups on the surface that interact with positively charged calcium ions forming calcium titanate [56].…”

Section: Mineralization Of Tinpls and Tinws By Spontaneous Precipitationmentioning

confidence: 73%

“…This indicates that, as shown by Uchida et.al., a specific arrangement of Ti-OH groups is also needed and it depends both on NMs composition and morphology [57]. TiNPls used in this work, and TiNPs from our recent study [13] are both anatase. However, CaP formation on TiNPs was observed already after the first day of soaking which can be attributed to the different morphology.…”

Section: Tinpls and Tinws Characterizationmentioning

confidence: 99%

“…Another possible route of biomimetically coating TiNMs is to use them as a suspended substrate during CaP's precipitation at physiological pH. In our recent article, we have shown that by using precipitation systems with higher supersaturation than in c-SBF it is possible to coat TiNPs and TiNTs with CaDHA [13]. To the best of our knowledge, no Although TiNPls and TiNWs showed a low ability to induce CaP formation in SBF, as well as TiNPs and TiNTs investigated in a previous study [13], some trends in the influence of morphology and surface structure of TiNMs could be observed.…”

Section: Mineralization Of Tinpls and Tinws By Spontaneous Precipitationmentioning

confidence: 99%

“…The modern way of life and population aging results in an increased frequency of chronic diseases, among which the most significant are hard tissue (bone and teeth) chronic substrate during precipitation of CaP from a precipitation system with reactant concentrations somewhat higher than physiological at 25 • C. Already within 1 h, the uniform CaDHA layer was formed on the surface of both TiNMs [13]. To the best of our knowledge, no biomimetic preparation of composites with other types of TiNM has been performed to date.…”

Section: Introductionmentioning

confidence: 99%

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Precipitation at Room Temperature as a Fast and Versatile Method for Calcium Phosphate/TiO2 Nanocomposites Synthesis

et al. 2021

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The constantly growing need for advanced bone regeneration materials has motivated the development of calcium phosphates (CaPs) composites with a different metal or metal-oxide nanomaterials and their economical and environmentally friendly production. Here, two procedures for the synthesis of CaPs composites with TiO2 nanoplates (TiNPl) and nanowires (TiNWs) were tested, with the immersion of TiO2 nanomaterials (TiNMs) in corrected simulated body fluid (c-SBF) and precipitation of CaP in the presence of TiNMs. The materials obtained were analyzed by powder X-ray diffraction, spectroscopic and microscopic techniques, Brunauer–Emmett–Teller surface area analysis, thermogravimetric analysis, dynamic and electrophoretic light scattering, and their hemocompatibility and ability to induce reactive oxygen species were evaluated. After 28 days of immersion in c-SBF, no significant CaP coating was formed on TiNMs. However, the composites with calcium-deficient apatite (CaDHA) were obtained after one hour in the spontaneous precipitation system. In the absence of TiNMs, CaDHA was also formed, indicating that control of the CaP phase formed can be accomplished by fine-tuning conditions in the precipitation system. Although the morphology and size of crystalline domains of CaDHA obtained on the different nanomaterials differed, no significant difference was detected in their local structure. Composites showed low reactive oxygen species (ROS) production and did not induce hemolysis. The results obtained indicate that precipitation is a suitable and fast method for the preparation of CaPs/TiNMs nanocomposites which shows great potential for biomedical applications.

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Section: Tinpls and Tinws Characterizationsupporting

confidence: 73%