Calcium Phosphate Foam Ceramic Based on Hydroxyapatite–Brushite Powder Mixture

Крутько, В. К.; Кулак, А. И.; Musskaya, O. N.; Сафронова, Т. В.; Putlyaev, V. I.

doi:10.1007/s10717-019-00145-y

Cited by 11 publications

(6 citation statements)

References 15 publications

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“…The DCPD phase, enclosed in HA/DCPD mixtures, was occasionally found to partially or fully transform, by dehydration and condensation, into γ-Ca 2 P 2 O 7 at temperatures in the range of 500–600 °C, which further converts into the more stable β-Ca 2 P 2 O 7 and α-Ca 2 P 2 O 7 forms at ~700–800 °C and 1000–1200 °C, respectively, in air ambient [ 57 , 58 , 59 ] and at slightly more elevated temperatures in nitrogen [ 50 ]. Concurrently, up to 1200 °C, HA was found to gradually decompose into β-TCP or a mixture of β-TCP and α-TCP [ 19 , 60 ]. The high temperature de-hydroxylation of HA (with the intermediate formation of oxyapatite, regardless of the sintering ambient [ 51 , 52 ]) is known to be the main promoter of its conversion to β-TCP [ 53 , 61 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…The extension of the range of biomedical applicability requires continuous improvements of this category of bioactive materials. Of upmost importance for synthetic bone graft substitutes is their capacity to adapt to the implantation sites and aid the reparatory osteogenesis process without generating dramatic responses (i.e., immunologic, allergenic, mutagenic effects) [ 9 , 12 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, HA with/without β-TCP/α-TCP is usually destined for the fabrication of 3D compact and porous structures, while DCPD can be used alone or in combination with any other calcium phosphate for the preparation of bone cements and bone fillers [ 13 , 16 , 25 , 26 ]. Products fabricated predominantly of β-TCP and α-TCP are rarely suggested for load-bearing applications owing to their low resistance and high resorption rates and, thus, insufficient time for a proper bonding with the surrounding bone tissue [ 13 , 19 , 27 ]. However, the addition of different ratios of TCP materials was proposed for a controlled degradation rate and an improved protein adsorption on the implant surface [ 5 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

et al. 2021

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A successful bone-graft-controlled healing entails the development of novel products with tunable compositional and architectural features and mechanical performances and is, thereby, able to accommodate fast bone in-growth and remodeling. To this effect, graphene nanoplatelets and Luffa-fibers were chosen as mechanical reinforcement phase and sacrificial template, respectively, and incorporated into a hydroxyapatite and brushite matrix derived by marble conversion with the help of a reproducible technology. The bio-products, framed by a one-stage-addition polymer-free fabrication route, were thoroughly physico-chemically investigated (by XRD, FTIR spectroscopy, SEM, and nano-computed tomography analysis, as well as surface energy measurements and mechanical performance assessments) after sintering in air or nitrogen ambient. The experiments exposed that the coupling of a nitrogen ambient with the graphene admixing triggers, in both compact and porous samples, important structural (i.e., decomposition of β-Ca3(PO4)2 into α-Ca3(PO4)2 and α-Ca2P2O7) and morphological modifications. Certain restrictions and benefits were outlined with respect to the spatial porosity and global mechanical features of the derived bone scaffolds. Specifically, in nitrogen ambient, the graphene amount should be set to a maximum 0.25 wt.% in the case of compact products, while for the porous ones, significantly augmented compressive strengths were revealed at all graphene amounts. The sintering ambient or the graphene addition did not interfere with the Luffa ability to generate 3D-channels-arrays at high temperatures. It can be concluded that both Luffa and graphene agents act as adjuvants under nitrogen ambient, and that their incorporation-ratio can be modulated to favorably fit certain foreseeable biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

et al. 2021

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“…(«Вектон», Россия) при соотношении по массе ГА (800 °С) / моногидрат дигидрофосфата кальция 76 / 24 в среде 0,8 % поливинилового спирта (ПВС) с 72000 r M  (AppliChem, Германия) [18][19][20]. Пористую структуру формировали первичной термообработкой при 800 °С в течение 5 ч с сохранением архитектуры ППУ матрицы, окончательный отжиг проводили при 1200 °С в течение 3 ч. Дополнительные ГА слои получали путем последовательного нанесения суспензии ГА (800 °С) / 0, 4 % ПВС, содержащей 10 12  масс.…”

Section: Ca H Po H O unclassified

Modification of Calcium Phosphate Foam Ceramics With Bioapatite in SBF Solution

Крутько¹,

Маслова²,

Мусская³

et al. 2021

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

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Получена многофазная кальцийфосфатная пенокерамика, представленная Д -трикальцийфосфатом (65 %) и Д -пирофосфатом кальция (25 %), включающая гидроксиапатит ( 5 %) и а -трикальцийфосфат ( 5 %), пористостью 60 - 64 % со сквозной архитектурой пенополиуретана. Нанесение слоя гидроксиапатита приводило к увеличению содержания гидроксиапатита до 25 %, а -трикальцийфосфата до 40 %, и повышению статической прочности до 0,03 МПа при снижении пористости до 49 %. Нанесение второго слоя гидроксиапатита способствовало повышению содержания гидроксиапатита до 40 %, статическая прочность достигала 0,05 МПа при пористости 40%. Формирование биоапатита в виде слоя «пеносфер» размером от 2 до 10 мкм происходило в процессе модифицирования всех видов пенокерамики в растворе SBF в течение 21 - 28 суток. Модифицированная кальцийфосфатная пенокерамика, обогащенная а -трикальцийфосфатом и гидроксиапатитом, характеризовалась максимальной статической прочностью 0,08 МПа при пористости 38%. The multiphase calcium phosphate foam ceramics, represented by р -tricalcium phosphate (65 %) and р -calcium pyrophosphate (25 %), including hydroxyapatite (5 %) and а -tricalcium phosphate (5%), with 60 - 64% porosity and a through architecture of polyurethane foam was obtained. The application of a layer of hydroxyapatite led to an increase in the content of hydroxyapatite to 25 %, а -tricalcium phosphate to 40%, and an increase in static strength to 0,03 MPa with a decrease in porosity to 49%. The application of the second layer of hydroxyapatite promoted an increase in the content of hydroxyapatite to 40%, the static strength reached 0,05 MPa at a porosity 40 %. The bioapatite formation in the shape of «foam spheres» with a size from 2 to 10 pm occurred in the process of modifying all types of foam ceramics in a SBF solution during 21 - 28 days. The modified calcium phosphate foam ceramics enriched with а -tricalcium phosphate and hydroxyapatite, was characterized by the maximum static strength 0,08 MPa at a porosity 38 %.

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“…костных аутотрансплантатов позволяет достичь хороших результатов, но является затруднительным при необходимости закрытия обширных костных дефектов. Для восстановления больших дефектов кости используют искусственные биоматериалы на основе костной стружки пациента в смеси с гидроксиапатитом (ГА), деминерализованный костный матрикс, коллагеновые губки, кальцийфосфатную керамику в виде трехмерных конструкций, гранул [1][2][3][4][5][6], пористых матриксов из резорбируемых остеокондуктивных фосфатов кальция [7][8][9].…”

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Hibrid biomaterials based on hydroxyapatite and blood components

Крутько

Власов²,

Мусская

et al. 2019

Vescì Akademìì navuk Belarusì. Seryâ himičnyh navuk

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Hybrid biomaterials based on amorphous hydroxyapatite and blood components (fibrin, citrate plasma) were developed by chemical precipitation of hydroxyapatite in a biopolymer matrix (pH 11; Ca/P ratio 1.67) and by mixing 6–14 wt.% of hydroxyapatite gel (pH 7.0–7.2) with bipolymers. Chemically precipitated hydroxyapatite in biopolymer matrices is single phase or contains ticalcium phosphate impurity up to 30 %, mainly α-modification in fibrin matrix and β-modification in citrate plasma. The interaction of hydroxyapatite gel into the fibrin leads to significant amorphization of hydroxyapatite and an increase in its bioresorbability. Holding the composites with hydroxyapatite obtained by chemical precipitation in the Simulated Body Fluid model solution for 75 days leads to their partial resorption and simultaneous increase of biomimetic apatite, with its greater weight gain on composites with a fibrin. Hybrid biomaterials based on a fibrin obtained from the patient’s blood and hydroxyapatite gel showed positive result during implantation, allowing to form an adequate configuration of the defect, expanding the possibilities of ENT surgery.

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Calcium Phosphate Foam Ceramic Based on Hydroxyapatite–Brushite Powder Mixture

Cited by 11 publications

References 15 publications

Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

Fiber-Templated 3D Calcium-Phosphate Scaffolds for Biomedical Applications: The Role of the Thermal Treatment Ambient on Physico-Chemical Properties

Modification of Calcium Phosphate Foam Ceramics With Bioapatite in SBF Solution

Hibrid biomaterials based on hydroxyapatite and blood components

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