Calcium Phosphate Cement Augmentation of the Femoral Neck Defect Created After Dynamic Hip Screw Removal

Strauss, Eric J.; Pahk, Brian; Kummer, Frederick J.; Egol, Kenneth A.

doi:10.1097/bot.0b013e3180616ba5

Cited by 37 publications

(38 citation statements)

References 18 publications

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“…Besides, other successful attempts have been made to use these formulations for calcaneal fractures [509], hip fractures [510,511], augmentation of osteoporotic vertebral bodies [512], distal radius fractures [513], tibial plateau fractures [33,[513][514][515][516][517], restoration of pedicle screw fixation [518,519], reinforcement of thoracolumbar burst fractures [520], cancellous bone screws [521,522], in wrist arthrodesis [523] and for fixation of titanium implants [524]. A recent study on a cement augmentation of the femoral neck defect might be found elsewhere [525]. Considering their properties, calcium orthophosphate cements might potentially be applied to reinforce osteoporotic vertebral bodies [512,526].…”

Section: Orthopaedic Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Section: Orthopaedic Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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“…The advantages of CPC include a fast setting time, excellent moldability and good osteoconductivity (4,(6)(7)(8)(9). The early structural support that CPC offers is beneficial for large bone defects at risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, symptomatic patients complaining of recurrent pain or exhibiting a restricted range of motion in the affected joints are considered for surgical treatment (1,2,4). There are various surgical treatment strategies for benign bone tumors, consisting of curettage, curettage with autologous/allogeneic bone grafting, and curettage with artificial bone grafting (3)(4)(5)(6)(7)(8). Calcium phosphate cement (CPC) is an injectable biocompatible bone substitute that has been used for various applications in orthopedic surgery, due to its easy handling, high mechanical strength and good osteoconductive biological properties (4,(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

“…There are various surgical treatment strategies for benign bone tumors, consisting of curettage, curettage with autologous/allogeneic bone grafting, and curettage with artificial bone grafting (3)(4)(5)(6)(7)(8). Calcium phosphate cement (CPC) is an injectable biocompatible bone substitute that has been used for various applications in orthopedic surgery, due to its easy handling, high mechanical strength and good osteoconductive biological properties (4,(6)(7)(8)(9). A previous study reported that CPC offered a useful bone substitute for the treatment of bone and soft tissue tumors; however, the follow-up time was short (median follow-up, 18.5 months) (6).…”

Section: Introductionmentioning

confidence: 99%

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Treatment of bone defect with calcium phosphate cement subsequent to tumor curettage in pediatric patients

et al. 2015

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Abstract. The aim of the present study was to investigate the mid-to long-term clinical performance of calcium phosphate cement (CPC) in the treatment of benign bone tumors in pediatric patients with a follow-up of at least 2-years. The cases of 33 patients with benign bone tumors treated by curettage and subsequent implantation of CPC were retrospectively reviewed. The patients consisted of 13 males and 20 females, with a median age of 13 years and median follow-up time of 79 months. All patients were alive at the time of review. No toxicity was detected in routine blood tests. Radiography was used to confirm that CPC was well adapted to the surrounding host bone, although the resorbability of CPC was not obtained for all patients at the final follow-up. Local tumor recurrence occurred in 4 patients. None of the patients reported post-operative fractures. In total, 6 patients required a second surgical procedure, as follows: 4 patients in whom local tumor recurrence occurred; 1 patient with post-operative superficial wound infection, who underwent wound debridement; and 1 patient that required the removal of CPC due to deep infection at the proximal humerus. All patients had regained full physical function without any pain at the final follow-up. The present study recommends that the properties of CPC should be taken into consideration and applied to the reconstruction of bone defects subsequent to curettage of bone tumors.

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“…[1][2][3][4][5][6] Internal stabilization of fractured or otherwise mechanically destabilized bone oft en occurs in the presence of compromised bone quality. Placement of hardware into bone of reduced mechanical competency can signifi cantly aff ect the performance of the fi xation hardware, and ultimately the clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Fiber Reinforced Drillable Bone Cement for Screw Augmentation in a Sheep Model—Mechanical Testing

Ahern

Harten²,

Gruskin³

et al. 2010

Clinical Translational Sci

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We evaluated the mechanical properties of a novel fi ber reinforced calcium phosphate at time zero and after 12 weeks in vivo using a sheep long bone osteotomy model. Time zero data were obtained and compared by pullout testing of 4.5 mm bone screws from bone proper and overdrilled defects of 4.5 and 8 mm diameter. Defects were augmented with: polymethylmethacrylate (PMMA), calcium phosphate, and fi ber reinforced calcium phosphate using cadaveric sheep tibiae. Twelve-week data were obtained from explanted tibiae of sheep that underwent unilateral tibial osteotomy surgery repaired with a locking compression plate. The most distal hole was overdrilled to 4.5 or 8 mm diameter, fi lled with fi ber reinforced cement, drilled, tapped and a 4.5 mm screw was placed. Screw holding strength at t = 0 was signifi cantly higher for reinforced when compared to nonreinforced cement, but not different from bone or PMMA in 4.5 mm defects. There was no difference in pullout strength for the 8 mm defect data. After 12 weeks fi ber reinforced pullout strength increased by 45% and 8.9% for 4.5 and 8 mm defects, respectively, when compared to t = 0 testing. Fiber reinforced calcium phosphate bone cement can be drilled and tapped to support orthopedic hardware for trauma applications.

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Calcium Phosphate Cement Augmentation of the Femoral Neck Defect Created After Dynamic Hip Screw Removal

Cited by 37 publications

References 18 publications

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Treatment of bone defect with calcium phosphate cement subsequent to tumor curettage in pediatric patients

Evaluation of a Fiber Reinforced Drillable Bone Cement for Screw Augmentation in a Sheep Model—Mechanical Testing

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