Calcium-Phosphate and Polymethylmethacrylate Cement in Long-term Outcome After Kyphoplasty of Painful Osteoporotic Vertebral Fractures

Grafe, Ingo; Baier, Martin; Nöldge, G.; Weiß, Christel; Fonseca, K. Da; Hillmeier, J.; Libicher, M.; Rudofsky, Gottfried; Metzner, Cornelia; Nawroth, Peter P.; Meeder, P. J.; Kasperk, Christian

doi:10.1097/brs.0b013e3181714a84

Cited by 99 publications

(66 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Included Articles N=27 of the studies reported effects for the same group of patients and were combined into one analyzable ''study'' (Kasperk/Grafe et al, 4 total [11,12,24,25] and Rousing et al, 2 total [20,26]; see Table 1). This systematic review was reported in accordance with the PRISMA statement [27].…”

Section: Bkp Vs Nsm N=6mentioning

confidence: 99%

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

et al. 2012

View full text Add to dashboard Cite

Purpose To determine if differences in safety or efficacy exist between balloon kyphoplasty (BKP), vertebroplasty (VP) and non-surgical management (NSM) for the treatment of osteoporotic vertebral compression fractures (VCFs). Methods As of February 1, 2011, a PubMed search (key words: kyphoplasty, vertebroplasty) resulted in 1,587 articles out of which 27 met basic selection criteria (prospective multiple-arm studies with cohorts of C20 patients).This systematic review adheres to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.Results Pain reduction in both BKP (-5.07/10 points, P \ 0.01) and VP (-4.55/10, P \ 0.01) was superior to that for NSM (-2.17/10), while no difference was found between BKP/VP (P = 0.35). Subsequent fractures occurred more frequently in the NSM group (22 %) compared with VP (11 %, P = 0.04) and BKP (11 %, P = 0.01). BKP resulted in greater kyphosis reduction than VP (4.88 vs. 1.7°, P \ 0.01). Quality of life (QOL) improvement showed superiority of BKP over VP (P = 0.04), along with a trend for disability improvement (P = 0.08). Cement extravasation was less frequent in the BKP (P = 0.01). Surgical intervention within the first 7 weeks yielded greater pain reduction than VCFs treated later. Conclusions BKP/VP provided greater pain relief and fewer subsequent fractures than NSM in osteoporotic VCFs. BKP is marginally favored over VP in disability improvement, and significantly favored in QOL improvement. BKP had a lower risk of cement extravasation and resulted in greater kyphosis correction. Despite this analysis being restricted to Level I and II studies, significant heterogeneity suggests that the current literature is delivering inconsistent messages and further trials are needed to delineate confounding variables.

show abstract

Section: Bkp Vs Nsm N=6mentioning

confidence: 99%

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Bisher wurde nur die Heidelberger Kyphoplastiestudie mit 12-und 36-MonatsLangzeitdaten publiziert [18,19,34,35,55]. In dieser kontrollierten, prospektiven, nicht randomisierten Studie wurden die Endpunkte Schmerz, Bewegung und Anschlussfrakturen bei chronisch schmerzhaften, über 12 Monate alten osteoporotischen Sinterungsfrakturen bei 60 Patienten (durchschnittliches Alter 69,2 Jahre; 20 Kontrollpatienten, 40 Patienten erhielten zusätzlich eine Kyphoplastie) nach 6, 12 und 36 Monaten untersucht.…”

Section: Kontrollierte Studienergebnisse Zur Kyphoplastieunclassified

“…Bei schmerzhaften, osteoporotischen Sinterungsfrakturen besteht prinzipiell die Möglichkeit den üblichen PMMA-Kunststoff oder einen Kalziumphosphatzement zu verwenden [19]. Der CaP-Zement ist prinzipiell durch Osteoklasten abbaubar.…”

Section: Bedeutung Des Verwendeten Implantatmaterialsunclassified

Indications and results of kypho- and vertebroplasty

et al. 2008

View full text Add to dashboard Cite

The best currently available evidence based treatment reduces vertebral fracture risk but does not totally prevent osteoporotic and malignant follow-up fractures. Kyphoplasty and vertebroplasty are options of a causal treatment to reduce pain by internal stabilization of fractured vertebrae. The indication for these minimal invasive procedures requires an interdisciplinary discussion of the individual case to guarantee technical feasibility, to increase the likelihood that these procedures will indeed reduce pain and to embed these procedures into the long term therapeutic concept of every single patient. In addition to internal stabilization of a painfully fractured vertebra kyphoplasty also seeks to restore lost vertebral height which appears promising in acute vertebral fractures. Due to the procedure there are more cement leakages after vertebroplasty. Available controlled prospective studies demonstrate only for kyphoplasty a long-term benefit for the patient in terms of pain reduction, increased mobility and improved quality of life.

show abstract

“…Nevertheless, biological cements are still expensive, and their manipulation is not easy, due to their high viscosity that hinders interstitial diffusion inside the vertebral body. 42 These materials have been recommended in high--energy fractures in young patients, 37 although other authors find a high rate of mechanical failure with these materials, due to their lower resistance to shear, flexion and distraction forces. 43 Theoretical mechanisms involved in pain relief after VAP have been proposed as being related to vertebral body stabilization of micro-movements and prevention of progressive vertebral collapse.…”

Section: Indications and Contra-indicationsmentioning

confidence: 99%

Controversies on Vertebroplasty and Kyphoplasty for Vertebral Compression Fractures

Teles

Mattei²,

Righesso

et al. 2015

Coluna/Columna

View full text Add to dashboard Cite

Vertebroplasty and kyphoplasty are widely used for osteoporotic and cancer-related vertebral compression fractures refractory to medical treatment. Many aspects of these procedures have been extensively discussed in the literature during the last few years. In this article, we perform a critical appraisal of current evidence on effectiveness and ongoing controversies regarding surgical technique, indications and contraindications, clinical outcomes and potential complications of these procedures.

show abstract

Calcium-Phosphate and Polymethylmethacrylate Cement in Long-term Outcome After Kyphoplasty of Painful Osteoporotic Vertebral Fractures

Cited by 99 publications

References 33 publications

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies

Indications and results of kypho- and vertebroplasty

Controversies on Vertebroplasty and Kyphoplasty for Vertebral Compression Fractures

Contact Info

Product

Resources

About