“…While ASIC1a, 2a, 2b, and 4 are widely expressed in both central and peripheral sensory neurons, ASIC1b and 3 are found primarily in sensory neurons (Waldmann et al, 1999;Krishtal, 2003 (Stockand et al, 1993;Chen et al, 1997;Paoletti et al, 1997;Shafer, 1998;Fayyazuddin et al, 2000;Sharonova et al, 2000;Gavazzo et al, 2001;Erreger and Traynelis, 2005). For endogenous and recombinant ASIC, the effects of Zn 2þ and Pb 2þ are dose-dependent and reversible with the actions of these metals often being subunit specific (Baron et al, 2001(Baron et al, , 2002Chu et al, 2004;Gao et al, 2004;Wang et al, 2006). Regulation of ASIC by Cd 2þ and Ni 2þ , in contrast, has not been reported.…”