Calcium Metabolism in the Morbidly Obese

Hamoui, Nahid; Anthone, Gary J.; Crookes, Peter F.

doi:10.1381/096089204772787211

Cited by 132 publications

(94 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are in agreement with previous reports of increased PTH concentrations in obese, compared with normal-weight, patients (7)(8)(9)(10)(11)26 ). Increased sequestration of vitamin D in adipose tissue has been proposed as a possible explanatory mechanism for these results (6 -8 ).…”

Section: Discussionsupporting

confidence: 92%

“…Despite the fact that obese individuals have a larger total surface area to expose to sunlight, which would be expected to produce more vitamin D, it has been shown previously that 25-hydroxyvitamin D (25-⌷⌯-vitamin D) concentrations are decreased in obesity (6 -8 ). As a result of decreased bioavailability of vitamin D in obese individuals, PTH concentrations are significantly higher, independent of age, sex, and race (7)(8)(9)(10)(11). It is possible that subcutaneous fat, which has been known to store vitamin D, sequesters larger amounts in obese persons (6 -8 ).…”

mentioning

confidence: 99%

“…In morbid obesity, in addition to increased PTH (9 ), increased binding of calcium to plasma proteins has also been reported (13 ). Moreover, PTH itself may promote weight gain because physiologic increases in PTH have been shown to increase intracellular calcium ion (Ca 2ϩ ) concentrations, which appear to promote triglyceride accumulation in adipose tissue by exerting coordinated control over lipogenesis and lipolysis (14,15 ).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Serum Parathyroid Hormone Concentrations Are Increased in Women with Polycystic Ovary Syndrome

et al. 2005

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Serum Parathyroid Hormone Concentrations Are Increased in Women with Polycystic Ovary Syndrome

et al. 2005

View full text Add to dashboard Cite

“…In addition, PTH was positively correlated with BMI and body fat mass in study of 302 nonobese and obese mixed race adults 24 and in morbidly obese patients. 25 Several studies show that PTH declines with weight loss, either diet-induced 5 or following gastric surgery for obesity. 6 Similar to these reports, our results support a positive relationship between PTH and body fat mass in a crosssectional analyses, and we also demonstrate that a change in PTH correlates to a change in body fat mass in a prospective analysis.…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone is associated with decreased fat mass in young healthy women

et al. 2005

View full text Add to dashboard Cite

Objective: To investigate the relationship of parathyroid hormone (PTH) with dietary calcium and changes in body composition. Design: Cross-sectional and 1-year longitudinal trial. Subjects: Normal-weight young women (age: 18-31), 155 subjects analyzed at baseline, and data for 41 subjects analyzed prospectively between baseline and 12 months. Measurements: Levels of fasting serum calcium and PTH, intakes of calcium (3-day diet records), and total body weight and body composition (dual energy X-ray absorptiometry). Results: Baseline dietary calcium, regardless of whether unadjusted or adjusted for energy intake, did not predict baseline levels of fasting serum PTH. Change in dietary calcium also did not predict change in serum PTH. However, log PTH was significantly correlated with body fat mass (R ¼ 0.27), but not lean mass at baseline (n ¼ 155), independent of serum calcium (corrected R ¼ 0.25). Further, 12-month changes (n ¼ 41) in log PTH positively predicted the 12-month change in body weight (R ¼ 0.32) and body fat (R ¼ 0.32), but not lean mass even when controlled for age or change in serum calcium. Conclusion: Fasting serum PTH was associated with increased fat mass, in both cross-sectional and prospective analysis. Thus, serum PTH may play a role in the regulation of body fat mass in young women.

show abstract

“…Parathormone (PTH) levels are positively correlated with BMI, and 25-48% of obese individuals have an elevated PTH concentration [29]. Up to 25% of obese patients who have not undergone bariatric surgery have a pre-existing subclinical calcium deficiency (elevated PTH with normal Ca 2+ ) [30]. This constellation of abnormalities predisposes extremely obese patients to low bone mass and osteomalacia even before surgery.…”

Section: Metabolic Bone Disease Managementmentioning

confidence: 99%

Management of the post-bariatric surgery patient – what an internist needs to know

Handzlik-Orlik

Holecki

Kędzierski

et al. 2016

noms

View full text Add to dashboard Cite

Bariatric surgery is the most effective method of achieving long-lasting weight loss and improving metabolic and cardiovascular outcomes in selected obese patients (i.e. with body mass index [BMI] ≥ 40 kg/m 2 without coexisting morbidities or BMI ≥ 35 kg/m 2 with severe obesity-related diseases). As the epidemic of obesity grows, it is estimated that by 2030 around 11% of the population will be severely obese. Therefore, the number of bariatric procedures performed increases year after year, and it reached 179,000 in 2013. Bariatric procedures can be divided into three main types: restrictive, malabsorptive, and mixed procedures. While, careful multi-disciplinary preoperative assessment of the patient is an inseparable part of bariatric procedures, there is also a need for multi-disciplinary management after bariatric surgery. This should include surveillance by an internist, surgeon and registered dietician. However, treatment outcome is primarily dependent on the patient's compliance and awareness of the need for regular follow-up. This cannot be achieved without proper behavioral and psychological support, as it is as vital as other surveillance aspects. In this review we discuss early and late complications of bariatric surgery, its influence on obesity-related diseases, and changes in body composition and metabolism. According to recent guidelines and recommendations of American and European medical societies, we summarize available standards of post-bariatric management.

show abstract

Calcium Metabolism in the Morbidly Obese

Cited by 132 publications

References 4 publications

Serum Parathyroid Hormone Concentrations Are Increased in Women with Polycystic Ovary Syndrome

Serum Parathyroid Hormone Concentrations Are Increased in Women with Polycystic Ovary Syndrome

Parathyroid hormone is associated with decreased fat mass in young healthy women

Management of the post-bariatric surgery patient – what an internist needs to know

Contact Info

Product

Resources

About