Calcium, magnesium, zinc and lead concentrations in the structures forming knee joint in patients with osteoarthritis‬

Kosik-Bogacka, Danuta; Łanocha-Arendarczyk, Natalia; Kot, Karolina; Ziętek, Paweł; Karaczun, Maciej; Prokopowicz, Adam; Kupnicka, Patrycja; Ciosek, Żaneta

doi:10.1016/j.jtemb.2018.08.007

Cited by 18 publications

(19 citation statements)

References 52 publications

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“…Farr et al have demonstrated using accelerometry that the majority of patients with knee OA do not meet the recommended levels of physical activity [19] which results in weight gain and obesity, progression of OA and impairment of function [20]. Finally, significantly higher concentrations of calcium have been found in the meniscus of individuals with knee OA undergoing total knee replacement surgery [21].…”

Section: Methodsmentioning

confidence: 99%

Impact of osteoarthritis on activities of daily living: does joint site matter?

et al. 2019

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Background We consider the relationships between a clinical and radiological diagnosis of knee or hip OA and activities of daily-living (ADL) in older adults. Methods Data were available for 222 men and 221 women from the Hertfordshire Cohort Study (HCS) who also participated in the UK component of the European Project on Osteoarthritis (EPOSA). Participants completed the EuroQoL survey where they reported if they had difficulties with mobility, self-care, usual activities and movement around their house. Hip and knee radiographs were graded for overall Kellgren and Lawrence score (positive definition defined as a 2 or above). Clinical OA was defined using American College of Rheumatology criteria. Results In men, a clinical diagnosis of hip or knee OA were both associated with reported difficulties in mobility, ability to self-care and performing usual-activities (hip OA:

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Section: Methodsmentioning

confidence: 99%

Impact of osteoarthritis on activities of daily living: does joint site matter?

et al. 2019

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“…After complete defrosting to room temperature, samples of the placenta, fetal membranes and umbilical cords were dried to a constant mass at 105 °C. The dried samples were mineralized; more details of the analytical procedures are given by Kosik-Bogacka et al [47,48]. Determination of Ag, Ca, Cd, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Sn, Sr, V and Zn was performed by spectrophotometric atomic absorption in inductively coupled argon plasma (ICP AES), on a Perkin-Elmer Optima 2000 DV (USA).…”

Section: Methodsmentioning

confidence: 99%

Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord

Kot

Kosik-Bogacka

Łanocha-Arendarczyk

et al. 2019

IJERPH

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The aim of the study was to investigate relationships between the concentrations of macroelements (Ca), microelements (Cr, Cu, Fe, Mn, Mo, Ni, Sn, Sr, V, Zn) and heavy metals (Ag, Cd, Pb) in the placenta, fetal membrane and umbilical cord. ‪Furthermore, we examined relationships between the concentrations of these metals in the studied afterbirths and maternal age, gestational age, placenta parameters (breadth, length, weight) and newborn parameters (length, weight and Apgar score). This study confirms previously reported Zn-Cd, Pb-Cd and Ni-Pb interactions in the placenta. New types of interactions in the placenta, fetal membrane and umbilical cord were also noted. Analysis of the correlations between metal elements in the afterbirths (placenta, fetal membrane and umbilical cord) and biological parameters showed the following relationships: maternal age and Mn (in the fetal membrane); gestational age and Cr, Fe, Zn (in the fetal membrane), Ag and Cu (in the umbilical cord); newborn’s length and Sr (in the placenta), Ag (in the umbilical cord); newborn’s weight and Sr (in the placenta), Cu (in the fetal membrane), Ag (in the umbilical cord); Apgar score and Ca, Cr and Ni (in the umbilical cord); placenta’s length and Cr and Sn (in the fetal membrane), Cu (in the umbilical cord); placenta’s width and Mo, Pb (in the placenta) and placenta weight and Sr (in the placenta), Ag, Fe, Mn (in the fetal membrane). The results show the influence of metals on the placenta, mother and newborn parameters, and the same point indicates the essential trace elements during the course of pregnancy.

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“…Such coupling of the neuronal models with the proposed model would assist in our better understanding of the molecular changes affecting the neuronal behavior, such as in quantifying the exact damage to the axons during the application of RF procedures for treating pain. Future studies can be conducted by incorporating the actual physiological neuronal geometries and modeling of biophysical phenomena at sub-cellular scale, viz., accounting for changes in the concentrations of potassium, sodium, calcium and magnesium at the membrane layer [78,[144][145][146][147][148]. Such multiscale, multiphysics and fully coupled models will provide a better understanding of the molecular changes affecting the neuronal behavior, along with quantification of the mitigation of actual pain signals during RF procedures.…”

Section: Coupling Framework and Pain Relief Modelsmentioning

confidence: 99%

Domain Heterogeneity in Radiofrequency Therapies for Pain Relief: A Computational Study with Coupled Models

Singh

Melnik

2020

Bioengineering

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The objective of the current research work is to study the differences between the predicted ablation volume in homogeneous and heterogeneous models of typical radiofrequency (RF) procedures for pain relief. A three-dimensional computational domain comprising of the realistic anatomy of the target tissue was considered in the present study. A comparative analysis was conducted for three different scenarios: (a) a completely homogeneous domain comprising of only muscle tissue, (b) a heterogeneous domain comprising of nerve and muscle tissues, and (c) a heterogeneous domain comprising of bone, nerve and muscle tissues. Finite-element-based simulations were performed to compute the temperature and electrical field distribution during conventional RF procedures for treating pain, and exemplified here for the continuous case. The predicted results reveal that the consideration of heterogeneity within the computational domain results in distorted electric field distribution and leads to a significant reduction in the attained ablation volume during the continuous RF application for pain relief. The findings of this study could provide first-hand quantitative information to clinical practitioners about the impact of such heterogeneities on the efficacy of RF procedures, thereby assisting them in developing standardized optimal protocols for different cases of interest.

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Calcium, magnesium, zinc and lead concentrations in the structures forming knee joint in patients with osteoarthritis‬

Cited by 18 publications

References 52 publications

Impact of osteoarthritis on activities of daily living: does joint site matter?

Impact of osteoarthritis on activities of daily living: does joint site matter?

Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord

Domain Heterogeneity in Radiofrequency Therapies for Pain Relief: A Computational Study with Coupled Models

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