Calcium, lithium, and circadian rhythms

Terao, Takeshi

doi:10.1016/0006-3223(92)90149-t

Cited by 2 publications

(1 citation statement)

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“…To probe potential causative links between disrupted circadian clocks and mania, animal models must be leveraged. Several lines of evidence demonstrate that treating hamsters with lithium chloride (a potent pharmacological agent used to treat manic depressive disorders) significantly lengthens the period of their circadian clock (Terao, 1992; LeSauter and Silver, 1993; Klemfuss and Kripke, 1995; Iwahana et al, 2007). Detailed molecular work has shown that lithium treatment can alter several intracellular signaling cascades, including glycogen synthase kinase-3beta, a link to the circadian molecular clockworks (Iwahana et al, 2004; Padiath et al, 2004; Iitaka et al, 2005; Ko et al, 2010; Lamont et al, 2010; Osland et al, 2011).…”

Section: Links Between Circadian Disruption and Psychiatric Disordersmentioning

confidence: 99%

Links between Circadian Rhythms and Psychiatric Disease

Karatsoreos

2014

Front. Behav. Neurosci.

124

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Determining the cause of psychiatric disorders is a goal of modern neuroscience, and will hopefully lead to the discovery of treatments to either prevent or alleviate the suffering caused by these diseases. One roadblock to attaining this goal is the realization that neuropsychiatric diseases are rarely due to a single gene polymorphism, environmental exposure, or developmental insult. Rather, it is a complex interaction between these various influences that likely leads to the development of clinically relevant syndromes. Our lab is exploring the links between environmental exposures and neurobehavioral function by investigating how disruption of the circadian (daily) clock alters the structure and function of neural circuits, with the hypothesis that disrupting this crucial homeostatic system can directly contribute to altered vulnerability of the organism to other factors that interact to produce psychiatric illness. This review explores some historical and more recent findings that link disrupted circadian clocks to neuropsychiatric disorders, particularly depression, mania, and schizophrenia. We take a comparative approach by exploring the effects observed in human populations, as well as some experimental models used in the laboratory to unravel mechanistic and causal relationships between disruption of the circadian clock and behavioral abnormalities. This is a rich area of research that we predict will contribute greatly to our understanding of how genes, environment, and development interact to modulate an individual’s vulnerability to psychiatric disorders.

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