“…However, it is challenging to control the self‐assembly behavior of proteins because of the complicated, heterogeneous protein surfaces, which can interact with each other in unpredictable ways (Bai et al, ; Zhou et al, ). In addition, some external factors may also affect the conformation transition of proteins (Zong et al, ), Response:, including pH value, temperature, or redox potential as well as enzymatic modification of peptides (Top et al, ; Williams et al, ; Kühnle et al, ). Moreover, many researches have pointed that some metal ions such as Al 3+ , Fe 3+ , Cu 2+ , and Zn 2+ (Pagel et al, ; Zaykov et al, ; Zhang et al, ), can trigger structural transformations, aggregation, and fibrillation of human α‐synuclein and amyloid‐β peptide.…”