Calcium Ions to Remotely Control the Reversible Switching of Secondary and Quaternary Structures in Bioconjugates

Kühnle, Romina I.; Börner, Hans G.

doi:10.1002/anie.201100141

Cited by 39 publications

(42 citation statements)

References 36 publications

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“…Ponnumallayan and Fee incorporated the ELELELELELFG peptide (EL‐5FG) to obtain reversible self‐assembling hydrogels . Peptides with alternating hydrophilic/hydrophobic residues are known to promote β‐sheet structures and by using glutamic acid as charged residues, the peptide became pH responsive (pH ≈ 5) . The conjugate was obtained through the reaction of NHS‐PEG with peptide's free amine at the N ‐terminus.…”

Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 99%

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Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Radvar

Azevedo

2018

Macromolecular Bioscience

124

107

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Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.

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Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 99%

“…Alternative peptide‐PNIPAAm conjugates were also described by Zhou et al. using the LLEELLEELEELLEEA (LE) peptide, inspired from the sequence reported by Kuhnle et al . LE forms α‐helix structures in the presence of calcium ions .…”

Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 99%

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Radvar

Azevedo

2018

Macromolecular Bioscience

124

107

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“…Bioinspired peptide-polymer/ protein-polymer conjugates are widely used for a broad range of applications (25), including enzyme stabilization (26)(27)(28)(29) the self-organization of bioconjugates (30)(31)(32)(33), or in adhesive systems, where proteins have proved to serve as excellent interfaces between organic and inorganic materials (34)(35)(36).…”

Section: Bioinspired Design Of Bioconjugatesmentioning

confidence: 99%

Peptide-Polymer Conjugates as Model Systems To Explore the Functional Space of Precision Polymers

Brummelhuis

Wieczorek

Wilke

et al. 2014

ACS Symposium Series

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“…However, it is challenging to control the self‐assembly behavior of proteins because of the complicated, heterogeneous protein surfaces, which can interact with each other in unpredictable ways (Bai et al, ; Zhou et al, ). In addition, some external factors may also affect the conformation transition of proteins (Zong et al, ), Response:, including pH value, temperature, or redox potential as well as enzymatic modification of peptides (Top et al, ; Williams et al, ; Kühnle et al, ). Moreover, many researches have pointed that some metal ions such as Al 3+ , Fe 3+ , Cu 2+ , and Zn 2+ (Pagel et al, ; Zaykov et al, ; Zhang et al, ), can trigger structural transformations, aggregation, and fibrillation of human α‐synuclein and amyloid‐β peptide.…”

Section: Introductionmentioning

confidence: 99%

Influence of reaction conditions on the self‐assembly of the natural silk sericin protein

Zhong

et al. 2016

Microscopy Res & Technique

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In the past years, the self-assembly of specific proteins has been paid more and more attention due to their significant role in human health and fabrication of new materials. In this article, we explore the effect of reaction conditions on the self-assembly of natural silk sericin protein, including the molecular weight and the concentration of sericin, pH, and metal ions in the reaction system. The results indicate that all these factors, especially species and concentration of metal ions, could influence the self-assembly process of the silk sericin protein. A series of assemblies with various morphologies can be fabricated by modulating the reaction condition. The article may provide some clue for the understanding of the protein self-assembly in the body and a method to fabricate new organic materials with different morphology. Microsc. Res. Tech. 80:298-304, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

Calcium Ions to Remotely Control the Reversible Switching of Secondary and Quaternary Structures in Bioconjugates

Cited by 39 publications

References 36 publications

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Peptide-Polymer Conjugates as Model Systems To Explore the Functional Space of Precision Polymers

Influence of reaction conditions on the self‐assembly of the natural silk sericin protein

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