Calcium-Ion-Triggered Co-assembly of Peptide and Polysaccharide into a Hybrid Hydrogel for Drug Delivery

Xie, Yanyan; Zhao, Jianlin; Huang, Renliang; Wang, Yuefei; Su, Rongxin; He, Zhimin

doi:10.1186/s11671-016-1415-8

Cited by 38 publications

(30 citation statements)

References 35 publications

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“…Selfassembling, ionic-complementary peptides are also being studied by researchers (Chen, 2005). The synergistic effect of both non-covalent and ionic interactions has been reported to provide better stability to the studied hydrogel (Xie et al, 2016).…”

Section: Ionic Interactionsmentioning

confidence: 99%

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Gupta

Singh

Sharma

et al. 2020

Front. Bioeng. Biotechnol.

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The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are privileged to make the cutoff for sensing the cell-signal for biologics delivery and tissue engineering. The signature service and insoluble network formation of the peptide self-assemblies as hydrogels have drawn a spell of research activity among the scientists all around the globe in the past decades. The therapeutic peptide market players are anticipating promising growth opportunities due to the ample technological advancements in this field. The presence of the other organic moieties, enzyme substrates and well-established protecting groups like Fmoc and Boc etc., bring the best of both worlds. Since the large sequences of peptides severely limit the purification and their isolation, this article reviews the account of last 5 years' efforts on novel approaches for formulation and development of single molecule amino acids, ultra-short peptide self-assemblies (di-and tri-peptides only) and their derivatives as drug/gene carriers and tissue-engineering systems.

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Section: Ionic Interactionsmentioning

confidence: 99%

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Gupta

Singh

Sharma

et al. 2020

Front. Bioeng. Biotechnol.

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“…One simple way to improve the mechanical properties of these systems is to combine them with covalent polymers. Covalent polymers are robust, and their non‐covalent functionalization with supramolecular polymers results in composite hydrogels with much improved mechanical and other physical properties …”

Section: Figurementioning

confidence: 99%

Composite of Peptide‐Supramolecular Polymer and Covalent Polymer Comprises a New Multifunctional, Bio‐Inspired Soft Material

Chakraborty

Ghosh

Schnaider

et al. 2019

Macromol. Rapid Commun.

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Engineering of extracellular matrix (ECM) mimics, with most of the necessary features of a natural ECM, is a crucial requirement for the design of biomaterials. The natural ECM encompasses a 3D network of intertwined protein nanofibers which contains complex biomolecules for communication between cells.[1] Short peptide-based 3D nanostructured supramolecular hydrogels are excellent candidates for ECM mimicry as they provide networks of fibers which resemble the ECM structure. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Modifications of certain oligopeptide termini with bio-active ligands, aimed to introduce bio-active components into the system, have also been reported. [22][23][24][25] The tripeptide sequence Arg-Gly-Asp (RGD), which was first recognized in fibronectin as an independent cell attachment site, is the most commonly used bio-active ligand. [26] This tri-peptide sequence is recognized by the α v β 3 and α 5 β 1 integrins located in cell membranes, thus facilitating the coupling of the ECM with the cytoskeleton. [27] Owing to these attributes, the RGD ligand has been introduced into supramolecular or polymeric substrates to facilitate cell attachment. [28][29][30][31] Fmoc-RGD [Fmoc = N-(fluorenyl-9-methoxycarbonyl)] is one of the simplest RGD derivatives capable of forming hydrogels with an inter-connected fibrous network. [15,27] Ulijn's group reported Fmoc-RGD based supramolecular hydrogels in neutral aqueous solution by appropriate mixing of two short peptidebased building blocks, Fmoc-FF (F = phenylalanine) and Fmoc-RGD and utilized them as scaffolds for cell culture. [15] They proposed that Fmoc-RGD alone was not able to form β-sheet fibrils, although in the composite gels of Fmoc-FF and Fmoc-RGD (10-30 wt% Fmoc-RGD), signatures of β-sheet structures were found. We later reported flanking of the RGD sequence by aromatic moieties, demonstrating the hydrogelation of RGD derivatives, including Fmoc-FRGD and Fmoc-RGDF. [32] Hamley and co-workers showed that the simple Fmoc-RGD moiety, without any modification or mixing with other hydrogelator peptides, could from nano-fibrous hydrogels. [27] Castelletto and co-workers prepared monoliths of Fmoc-RGD gels at a high peptide concentration of 10 wt% which showed excellent Bio-Inspired Soft MaterialsPeptide-based supramolecular hydrogels are utilized as functional materials in tissue engineering, axonal regeneration, and controlled drug delivery. The Arg-Gly-Asp (RGD) ligand based supramolecular gels have immense potential in this respect, as this tripeptide is known to promote cell adhesion. Although several RGD-based supramolecular hydrogels have been reported, most of them are devoid of adequate resilience and long-range stability for in vitro cell culture. In a quest to improve the mechanical properties of these tripeptide-based gels and their durability in cell culture media, the Fmoc-RGD hydrogelator is non-covalently functionalized with a biocompatible and biodegradable polymer, chitosan, resulting in a composite hydrog...

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“…The biocompatibility, biodegradability, and nonimmunogenicity of dipeptide-based LMWGs make them attractive candidates for biomedical applications. Within this class, Fmoc-modified diphenylalanine (Fmoc-FF) has been widely studied as the simplest and most effective hydrogelator (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). Fmoc-FF has been shown to form β-sheets that selfassemble laterally through π-π stacking of the fluorenyl groups into nanofibrous networks in which water is entrapped mainly by surface tension (15).…”

Section: Introductionmentioning

confidence: 99%

“…The formation of Fmoc-FF hydrogel can be triggered by either the "pH change" or "solvent exchange" (16,21). Recently, Fmoc-FFbased hybrid gels have been investigated as drug delivery systems (17,22,26). Indomethacin (IDM) is a nonsteroidal antiinflammatory drug that is widely used as an anodyne in the treatment of degenerative joint diseases such as rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Fmoc-diphenylalanine-based hydrogels as a potential carrier for drug delivery

Choe

Yun

2020

E-Polymers

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Self-assembled hydrogels from 9-fluorenylmethoxycarbonyl-modified diphenylalanine (Fmoc-FF) peptides were evaluated as potential vehicles for drug delivery. During self-assembly of Fmoc-FF, high concentrations of indomethacin (IDM) drugs were shown to be incorporated into the hydrogels. The β-sheet arrangement of peptides was found to be predominant in Fmoc-FF–IDM hydrogels regardless of the IDM content. The release mechanism for IDM displayed a biphasic profile comprising an initial hydrogel erosion-dominated stage followed by the diffusion-controlled stage. Small amounts of polyamidoamine dendrimer (PAMAM) added to the hydrogel (Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%) resulted in a more prolonged IDM release compared with Fmoc-FF 0.5%–IDM 0.5% hydrogel. Furthermore, these IDM-loaded hydrogels demonstrated excellent thixotropic response and injectability, which make them suitable candidates for use as injectable self-healing matrices for drug delivery.

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Calcium-Ion-Triggered Co-assembly of Peptide and Polysaccharide into a Hybrid Hydrogel for Drug Delivery

Cited by 38 publications

References 35 publications

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Composite of Peptide‐Supramolecular Polymer and Covalent Polymer Comprises a New Multifunctional, Bio‐Inspired Soft Material

Fmoc-diphenylalanine-based hydrogels as a potential carrier for drug delivery

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