Calcium ion cross-linking alginate/dexamethasone sodium phosphate hybrid hydrogel for extended drug release

Zhang, Renshu; Lei, Lei; Song, Qianqian; Li, Xingyi

doi:10.1016/j.colsurfb.2018.11.083

Cited by 65 publications

(31 citation statements)

References 32 publications

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“…Alginate (Alg) hydrogels have long been proposed for drug delivery 39,40 and tissue engineering applications 41,42 , as well as bioinks. 43,44 Alg and mucin have been previously mixed to disclose the mechanism of interaction relevant in CF.…”

Section: Alginate Hydrogelsmentioning

confidence: 99%

Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery

et al. 2019

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Section: Alginate Hydrogelsmentioning

confidence: 99%

Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery

et al. 2019

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“…This structure gives them the advantageous properties including biocompatibility, super hydrophilicity, and higher water absorption capacity. Due to these properties, hydrogels have been applied in many different areas such as ionic skin 1 , tissue engineering 2 , controlled drug delivery 3,4 , controlled drug release 5 , wound dressing and healing 6 , and so on. Therefore, more and more researchers are increasing their attention towards hydrogels in recent years.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly and biodegradable cellulose hydrogels produced from low cost okara: towards non-toxic flexible electronics

Cui

Lee

Chen

2019

Sci Rep

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With increasing resource shortage and environmental pollution, it is preferable to utilize materials which are sustainable and biodegradable. Side-streams products generated from the food processing industry is one potential avenue that can be used in a wide range of applications. In this study, the food by-product okara was effectively reused for the extraction of cellulose. Then, the okara cellulose was further employed to fabricate cellulose hydrogels with favorable mechanical properties, biodegrablability, and non-cytotoxicity. The results showed that it could be biodegraded in soil within 28 days, and showed no cytotoxicity on NIH3T3 cells. As a proof of concept, a demostration of wearable and biocompatible strain sensor was achieved, which allowed a good and stable detection of human body movement behaviors. The okara-based hydrogels could provide an alternative platform for further physical and/or chemical modification towards tissue engineering, medical supplies, or smart biomimetic soft materials.

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“…48,49 The alginate gelation occurs under mild reaction conditions with an addition of divalent cations such as calcium or barium. 50,51 In contrast to collagen hydrogels, alginate hydrogels have no intrinsic cell binding domains. 52 Hence, alginate hydrogels are usually conjugated with Arg-Gly-Asp (RGD) peptide to enhance cell-matrix interaction, improving stem cell adhesion and growth.…”

Section: Alginate Hydrogelmentioning

confidence: 99%

Composition and Mechanism of Three-Dimensional Hydrogel System in Regulating Stem Cell Fate

Huang

2020

Tissue Engineering Part B: Reviews

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Three-dimensional (3D) hydrogel systems integrating different types of stem cells and scaffolding biomaterials have an important application in tissue engineering. The biomimetic hydrogels that pattern cell suspensions within 3D configurations of biomaterial networks allow for the transport of bioactive factors and mimic the stem cell niche in vivo, thereby supporting the proliferation and differentiation of stem cells. The composition of a 3D hydrogel system determines the physical and chemical characteristics that regulate stem cell function through a biological mechanism. Here, we discuss the natural and synthetic hydrogel compositions that have been employed in 3D scaffolding, focusing on their characteristics, fabrication, biocompatibility, and regulatory effects on stem cell proliferation and differentiation. We also discuss the regulatory mechanisms of cell-matrix interaction and cell-cell interaction in stem cell activities in various types of 3D hydrogel systems. Understanding hydrogel compositions and their cellular mechanisms can yield insights into how scaffolding biomaterials and stem cells interact and can lead to the development of novel hydrogel systems of stem cells in tissue engineering and stem cell-based regenerative medicine.

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Calcium ion cross-linking alginate/dexamethasone sodium phosphate hybrid hydrogel for extended drug release

Cited by 65 publications

References 32 publications

Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery

Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery

Eco-friendly and biodegradable cellulose hydrogels produced from low cost okara: towards non-toxic flexible electronics

Composition and Mechanism of Three-Dimensional Hydrogel System in Regulating Stem Cell Fate

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