Calcium(II)-Mediated Three-Component Selenylation of gem-Difluoroalkenes: Access to α,α-Difluoroalkyl-β-selenides
Minyao Kuang,
Haokun Chen,
Yuwei Liu
et al.
Abstract:A calcium-mediated three-component selenylation of gem-difluoroalkenes using alcohols as nucleophiles and N-(phenylseleno)phthalimide as the selenylation agent has been developed for the efficient synthesis of various α,α-difluoroalkyl-βselenides. This selenylation reaction exhibits broad substrate and functional group tolerance, along with high levels of chemo-and regioselectivity. Additionally, the synthetic utility of the developed transformation in the late-stage functionalization of drug molecules was dem… Show more
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