Calcium Hydroxylapatite Dermal Filler for Treatment of Dorsal Hand Volume Loss: Results From a 12-Month, Multicenter, Randomized, Blinded Trial

Goldman, Mitchel P.; Moradi, Amir; Gold, Michael H.; Friedmann, Daniel P.; Alizadeh, Kaveh; Adelglass, Jeffrey; Katz, Bruce

doi:10.1097/dss.0000000000001203

Cited by 31 publications

(50 citation statements)

References 13 publications

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“…10,12 This scale has been used successfully in other studies of hand-volumizing treatment with dermal fillers and has demonstrated consistent intrarater and interrater agreement. 6,10,12,14 Improvements observed in the MHGS have previously corresponded to improvements in GAIS ratings and subject satisfaction. 6,14 These correlations were also corroborated in the current study and support the clinical relevance of the favorable aesthetic results with this hyaluronic acid product.…”

Section: Discussionmentioning

confidence: 76%

“…Although various products have been used to restore dorsal hand volume loss such as poly- l -lactic acid and calcium hydroxylapatite, at the time of this research study, there was only one non–hyaluronic acid product approved by the U.S. Food and Drug Administration for this indication (i.e., calcium hydroxylapatite). 5,6 However, a small open-label study provided promising results with small-gel-particle hyaluronic acid for the correction of volume loss in the dorsal hand. 7 Fat injections have been used for replenishing the volume deficits.…”

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confidence: 99%

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A Prospective, Multicenter, Randomized, Evaluator-Blinded, Split-Hand Study to Evaluate the Effectiveness and Safety of Large-Gel-Particle Hyaluronic Acid with Lidocaine for the Correction of Volume Deficits in the Dorsal Hand

Moradi

Allen

Bank

et al. 2019

Plastic &Amp; Reconstructive Surgery

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Background:Hand rejuvenation has become increasingly popular, but there are few reports published on the use of hyaluronic acid gels for correction of volume deficits in the dorsal hand.Methods:This study evaluated the efficacy and safety of large-gel-particle hyaluronic acid with lidocaine, a 20-mg/ml hyaluronic acid gel with 0.3% lidocaine, compared to no treatment for the correction of volume deficits in the dorsal hand. This was a prospective, multicenter, split-hand study in 90 subjects who received treatment with product in one hand. The primary efficacy endpoint was based on a 1 point of improvement with treatment versus no treatment according to the Merz Hand Grading Scale at week 12. Other assessments included Central Independent Photographic Reviewers evaluations of hand photographs, Global Aesthetic Improvement Scale, subject satisfaction, and safety.Results:The mean injection volume was 2.1 ml at the first treatment. Subjects demonstrated significantly higher response rates with treatment compared to no treatment at week 12 (85.9 percent versus 21.2 percent) and at weeks 16, 20, and 24 (p < 0.0001). Photographic Reviewers assessments showed consistently greater improvements in the treated hands compared with the untreated hands from week 12 to week 24. Most subjects and investigators (≥92.8 percent) reported improvements in Global Aesthetic Improvement Scale score across all time points with treatment. Treatment-related adverse events were reported in seven subjects (7.9 percent). Most of these were mild, and none were serious.Conclusion:Hyaluronic acid with lidocaine is safe, effective, and well tolerated for the correction of volume deficits in the dorsal hand.CLINICAL QUESTION/LEVEL OF EVIDENCE:Therapeutic, II.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

A Prospective, Multicenter, Randomized, Evaluator-Blinded, Split-Hand Study to Evaluate the Effectiveness and Safety of Large-Gel-Particle Hyaluronic Acid with Lidocaine for the Correction of Volume Deficits in the Dorsal Hand

Moradi

Allen

Bank

et al. 2019

Plastic &Amp; Reconstructive Surgery

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“…Clinical trials have demonstrated statistically significant improvement in dorsal hand volume after treatment with CaHA and even maintenance of these aesthetic results for up to 12 months after a single treatment. 13,14 Adverse events with this filler include temporary bruising and swelling, and rarely nodules that do not affect hand function. 14 Goldman et al 15 first reported the use of the efficacy and superiority of HA over collagen for dorsal hand augmentation.…”

Section: Dermal Fillersmentioning

confidence: 99%

“…13,14 Adverse events with this filler include temporary bruising and swelling, and rarely nodules that do not affect hand function. 14 Goldman et al 15 first reported the use of the efficacy and superiority of HA over collagen for dorsal hand augmentation. Recently, a small-particle hyaluronic acid (SPHA) injectable gel with lidocaine has been approved by the FDA for dorsal hand rejuvenation after demonstrating efficacy in further clinical trials.…”

Section: Dermal Fillersmentioning

confidence: 99%

Noninvasive body contouring by dermal fillers, radiofrequency, and focused ultrasound: A review

Alhaddad

Boen

Fabi

et al. 2020

Dermatological Reviews

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There has been a current trend in aesthetic medicine for patients to seek procedures with minimal downtime. To meet this demand, in the past few years, there have been several new energy-based devices in the market to treat unwanted fat noninvasively. Noninvasive body contouring involves almost no epidermal damage and minimal downtime. This review will focus on the use of dermal fillers to improve skin texture abnormalities, radiofrequency, and ultrasound devices for body contouring. Cryolipolysis, a popular body contouring technology, will be addressed in a separate paper by the authors due to a large amount of data on this topic.

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“…In a recent multicenter, randomized, controlled, single-blinded study, treatment has been shown to have a duration of effect of at least 12 months following a single procedure and is very well tolerated, with adverse events restricted to mild-to-moderate injection-site reactions and without issues relating to hand function. 19 …”

Section: Introductionmentioning

confidence: 99%

Combined aesthetic interventions for prevention of facial ageing, and restoration and beautification of face and body

Fabi

Pavicic²,

Braz

et al. 2017

CCID

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The Merz Institute of Advanced Aesthetics Expert Summit was held in Prague, Czech Republic, from 19–20 November 2016. The meeting had a distinct advisory board character and invited aesthetic practitioners from all over the world to hear an international faculty present a range of keynote lectures and conduct live injection sessions with an emphasis on recent developments in combination aesthetic interventions for face and body rejuvenation and beautification. Aging is associated with changes in bones, muscles, ligaments, adipose tissue, and skin and, moreover, involves interactions among these tissue types. To achieve the most natural and harmonious rejuvenation of the face, all changes that result from the aging process should be corrected, which generally involves treatment with more than a single agent or technology. Presentations described innovative treatment algorithms for the face and body and focused on patients’ desires for natural-looking rejuvenation and how this requires a three-dimensional approach combining products that relax the musculature, volumize, and re-drape the skin. Besides treating the aging face, these procedures are increasingly used to enhance facial features as well as to delay facial aging in younger patients. The presentations covered patients from different ethnicities as well as the treatment of non-facial areas, with a particular focus on the use of Ultherapy® for skin lifting and tightening, and new aesthetic procedures such as Cellfina® and diluted Radiesse®. The current report provides a summary of key presentations from the meeting.

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Calcium Hydroxylapatite Dermal Filler for Treatment of Dorsal Hand Volume Loss: Results From a 12-Month, Multicenter, Randomized, Blinded Trial

Abstract: Treatment with CaHA results in significant improvement in the appearance of the dorsal hand and is well tolerated.

Cited by 31 publications

References 13 publications

A Prospective, Multicenter, Randomized, Evaluator-Blinded, Split-Hand Study to Evaluate the Effectiveness and Safety of Large-Gel-Particle Hyaluronic Acid with Lidocaine for the Correction of Volume Deficits in the Dorsal Hand

A Prospective, Multicenter, Randomized, Evaluator-Blinded, Split-Hand Study to Evaluate the Effectiveness and Safety of Large-Gel-Particle Hyaluronic Acid with Lidocaine for the Correction of Volume Deficits in the Dorsal Hand

Noninvasive body contouring by dermal fillers, radiofrequency, and focused ultrasound: A review

Combined aesthetic interventions for prevention of facial ageing, and restoration and beautification of face and body

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