Calcium Hydroxide Mixed With Camphoric p-Monochlorophenol or Chlorhexidine in Delayed Tooth Replantation

Abstract

This study evaluated the repair process after delayed replantation of rat teeth, using calcium hydroxide (Ca(OH)2) mixed with camphorated p-monochlorophenol (CMCP), chlorhexidine 2% (CHX), or saline as temporary root canal dressing to prevent and/or control inflammatory radicular resorption. Thirty Wistar rats (Rattus norvegicus albinos) had their right upper incisor extracted, which was bench-dried for 60 minutes. The dental papilla, the enamel organ, the dental pulp, and the periodontal ligament were removed. The teeth were immersed in 2% acidulated-phosphate sodium fluoride solution for 10 minutes. The root canals were dried with absorbent paper cones and divided into 3 groups of 10 animals according to root canal dressing used: group 1: Ca(OH)2 + saline, group 2: Ca(OH)2 + CMCP, and group 3: Ca(OH)2 + CHX 2%. Before replanting, the teeth sockets were irrigated with saline. Histological analysis revealed the presence of inflammatory resorption, replacement resorption, and ankylosis in all 3 groups. Statistical analysis showed a significant difference between group 3 and the other groups. The use of Ca(OH)2 mixed with CMCP or CHX did not show an advantage over the use of Ca(OH)2 mixed with saline in preventing and/or controlling inflammatory resorption in delayed replantation of rat teeth.

Evaluation of calcium hydroxide mixed with propolis by ultrasonic activation as root canal dressing in delayed tooth replantation

“…It was observed in previous studies ( 19 ) that the calcium hydroxide paste underwent a solubilization in the region of the apex that compromised its action. This experimental model as well showed a broad apical foramen simulating a tooth with incomplete rhizogenesis.…”

“…In reimplantation it is very important that this alkalinizing action of the root canal and the dentinal tubules occurs as soon as possible because the installation of inflammatory resorption has already been observed histologically after 15 days of reimplantation ( 1 ). Various substances have been associated with calcium hydroxide in order to increase its antimicrobial power ( 19 ) and, among them, the propolis ( 21 ). Although its chemical composition depends on the species of bee and ecosystem ( 37 ), the propolis showed always as its inherent characteristic the antimicrobial action ( 38 ).…”

“…Some drugs like paramonoclorophenol, chlorhexidine ( 18 , 19 ) and propolis ( 20 , 21 ) have been associated with Ca(OH)2 in order to increase its antimicrobial effect. The propolis is a resinous substance made by bees, during the collection of plant resins and enzymes from the saliva itself.…”

Delayed tooth replantation in rats: effect of systemic antibiotic therapy with amoxicillin and tetracycline

“…Rat tooth, the experimental model used in the present study, has a wide apical foramen that can simulate the open apex of an immature tooth. As previously demonstrated, solubilization of the calcium hydroxide paste in the apical region reduces its activity and produces an inflammatory reaction when the material reaches the periapical tissues . Therefore, an MTA apical plug was prepared to avoid the contact between the intracanal medication and the periapical tissues , restraining its healing action to the root canal.…”