Calcium Homeostasis in Diabetes Mellitus*

Heath, Hunter; Lambert, Peter J.; Service, F. John; Arnaud, Sara B.

doi:10.1210/jcem-49-3-462

Cited by 131 publications

(47 citation statements)

References 32 publications

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“…Maternal and fetal corrected calcium val ues were significantly lower in diabetics than in controls, in agreement with the previous reports [15,19], On the other hand Heath et al [7] found no alterations in mineral values of nonpregnant diabetic subjects. We have not analyzed PTH.…”

Section: Resultssupporting

confidence: 92%

“…24,25(OH)2D values have been contra dictory in previous reports [1,6,7], The role of this metabolite is controversial [16]. The present and the previous study in nonpreg nant patients [1] showed low levels of the most active metabolite, l,25(OH)2D, in the group with type 1 diabetes.…”

Section: Resultscontrasting

confidence: 54%

“…Bone loss has been most pronounced during the first 5 years of disease, whereafter the bone mineral content has remained relatively constant, or possibly slightly increased due to the beneficial ef fects of insulin [2], The etiology of these alterations has been obscure. Because vita min D is one of the important hormones in regulating bone and mineral metabolism, its part has been abundantly studied in diabet ics, with contradictory results [1,[5][6][7], In experiments animals with induced diabetes a connection has been noticed between pan creatic insulin production and vitamin D metabolism [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Alterations in Vitamin D Metabolites and Minerals in Diabetic Pregnancy

Kuoppala

1988

Gynecol Obstet Invest

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Vitamin D metabolites and minerals involved in bone metabolism were studied in 68 control mothers, 14 gestational diabetics and 68 insulin-dependent diabetics during pregnancy and at delivery. 25(OH)D and 1,25(OH)₂D concentrations were significantly (p < 0.001) lower in insulin-dependent diabetics than in the control or gestational diabetic groups. A similar difference was also observed between infants. 24,25(OH)₂D, phosphorus and magnesium values were similar in all groups. Corrected calcium values were significantly lower in both mothers (p < 0.001) and infants (p < 0.05) in the insulin-dependent group than in the other two groups. Postpartum, 10% of infants of diabetic mothers received calcium therapy. Our results show alterations in vitamin D and mineral metabolism in pregnant insulin-dependent diabetics and their newborn infants and indicate observation during pregnancy and after delivery.

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Section: Resultssupporting

confidence: 92%

Section: Resultscontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

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Alterations in Vitamin D Metabolites and Minerals in Diabetic Pregnancy

Kuoppala

1988

Gynecol Obstet Invest

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“…In most (17, 51, 59, 63, 67-72), but not all (69,73,74), case-control studies, patients with type 2 DM or glucose intolerance are found to have lower serum 25-OHD concentration compared with controls without diabetes (Table 3).…”

Section: Evidence From Observational Human Studies What Is the Associmentioning

confidence: 99%

The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis

Pittas

Lau

et al. 2007

The Journal of Clinical Endocrinology &Amp; Metabolism

1,753

1,456

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Context: Altered vitamin D and calcium homeostasis may play a role in the development of type 2 diabetes mellitus (type 2 DM).Evidence Acquisition and Analyses: MEDLINE review was conducted through January 2007 for observational studies and clinical trials in adults with outcomes related to glucose homeostasis. When data were available to combine, meta-analyses were performed, and summary odds ratios (OR) are presented. is increasing at an alarming rate both nationally and worldwide, with more than 1 million new cases per year diagnosed in the United States alone (1). Diabetes is the fifth leading cause of death in the United States, and it is also a major cause of significant morbidity. Although our current methods of treating type 2 DM and its complications have improved, prevention of the disease is preferable. Indeed, epidemiological data suggest that nine of 10 cases of type 2 DM could be attributed to habits and forms of modifiable behavior (2). Potentially modifiable environmental risk factors for type 2 DM have been identified, the major one being obesity. Although weight loss (achieved by any means) has been shown to be successful in delaying type 2 DM, it is difficult to achieve and maintain long term. Therefore, identification of environmental and easily modified risk factors is urgently needed to prevent development of type 2 DM in the 41 million Americans who are at risk of the disease (3).The major and most well-known function of vitamin D is to maintain calcium and phosphorus homeostasis and promote bone mineralization. However, recent evidence suggests that vitamin D and calcium homeostasis may also be important for a variety of nonskeletal outcomes including neuromuscular function and falls, psoriasis, multiple sclerosis, and colorectal and prostate cancer (4, 5). Based on basic and animal studies, vitamin D and calcium have also been suspected as modifiers of diabetes risk. Vitamin D insufficiency has long been suspected as a risk factor for type 1 diabetes based on animal and human observational studies (6). More recently, there is accumulating evidence to suggest that altered vitamin D and calcium homeostasis may also play a role in the development of type 2 DM. The purpose of our systematic review was to examine: 1) the association between vitamin D and calcium status and risk of type 2 DM; and 2) the effect of vitamin D and/or calcium supplementation on glucose metabolism. Materials and MethodsWe searched MEDLINE for English-language literature through January 2007 for observational studies on the association between vitamin D/calcium status (defined by serum 25-hydroxyvitamin D (25-OHD) concentration, and vitamin D, calcium, or dairy intake) and type 2 DM (prevalence or incidence) and for randomized controlled trials of the effect of vitamin D and/or calcium supplementation in nonpregnant adults on outcomes related to glucose homeostasis. We also examined metabolic syndrome (prevalence or incidence) as an outcome of interest, given that insulin resistance, a feature of type 2 DM, is consid...

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“…Problems may be 2.67* *Significant difference in intragroup over follow-up time; **significant difference between the two study groups at the same follow-up time; ***significant difference between the two groups when compared overall Graph 3: Demographic details of the patients 1.74 *Significant difference between the study groups at baseline time of follow-up; **significant difference between the study groups at 1 year time of follow-up encountered by the clinician while planning dental implant surgeries in diabetic patients. 12 Hence, we assessed the clinicomicrobial and salivary profile of diabetic patients undergoing rehabilitation by dental implants. While evaluating the mean levels of IL-β during follow-up time, no significant correlation was obtained between the control group and diabetic group (p > 0.05) (Graph 1).…”

Section: Discussionmentioning

confidence: 99%

Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study

Raghav

Alqahtani

Albaker

et al. 2017

The Journal of Contemporary Dental Practice

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Introduction Replacement of missing teeth by dental implants is one of the most common methods employed these days. Because of significant advancement in the design of implants and modifications in the procedure of dental implant surgery, the survival rate of the dental implants has reached up to approximately 95%. Osseointegration is one of the important factors affecting the survival of dental implants. Apart from these, the body's physiologic alterations can also predispose the dental implants for failure. Diabetes is one such metabolic disease characterized by abnormal or delayed wound healing. Hence, we assessed the clinicomicrobial and salivary profile of diabetic patients undergoing rehabilitation by dental implants. Materials and methods This study included diabetic patients who underwent dental implant surgeries for prosthetic rehabilitation. Follow-up records of the patients’ up to 1 year were maintained. Various clinicoradiographic and periodontal parameters were measured at various time intervals during follow-up time; 25 mL of salivary and blood sample was taken from all the subjects and was sent to the laboratories for assessment of various salivary biomarkers. All the results were analyzed by Statistical Package for the Social Sciences software. Results The mean level of interleukin-â at baseline time was found to be 2.38 and 2.21 in diabetic group and control group respectively. While comparing the levels of osteoprotegerin in both study groups, a significant correlation was obtained. In diabetic and control group, 62 and 61 years was the mean age of the patients respectively. No significant correlation was obtained while comparing the microbial flora of diabetic and control group. Conclusion In both diabetic and nondiabetic patients, similar microbial, salivary marker, and clinicoradiological patterns were seen. Clinical significance Diabetic patients who maintain their body's metabolic rate show similar success rate of dental implants as seen in nondiabetic patients. How to cite this article Raghav D, Alqahtani F, Albaker FJ, Bhagat TV, Kola Z. Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study. J Contemp Dent Pract 2017;18(5):405-409.

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Calcium Homeostasis in Diabetes Mellitus*

Cited by 131 publications

References 32 publications

Alterations in Vitamin D Metabolites and Minerals in Diabetic Pregnancy

Alterations in Vitamin D Metabolites and Minerals in Diabetic Pregnancy

The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis

Intricate Assessment and Evaluation of Long-term Implant Success as affected by Clinicomicrobial and Salivary Diagnostics in Type II Diabetic Patients: A Longitudinal Study

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