Calcium homeostasis and modulation of synaptic plasticity in the aged brain

Foster, Thomas C.

doi:10.1111/j.1474-9726.2007.00283.x

Cited by 276 publications

(251 citation statements)

References 75 publications

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“…Whether these morphological changes are the cause or the consequence of decreased cognitive abilities is unknown. However, putative mechanisms underlying these changes could be based on an inability to maintain calcium homeostasis (Foster 2007), as one function of spines includes the compartmentalization of calcium ions and other signaling components (Fiala et al 2002;Burke and Barnes 2006). Naïve volunteers reliably assessed differences in Kenyon cell morphology within the beta lobes, where the majority of presented images could be classified into their respective age groups.…”

Section: Aging and The Mushroom Bodymentioning

confidence: 99%

The effect of age on a visual learning task in the American cockroach

Brown

Strausfeld²

2009

Learn. Mem.

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Neuronal modifications that accompany normal aging occur in brain neuropils and might share commonalties across phyla including the most successful group, the Insecta. This study addresses the kinds of neuronal modifications associated with loss of memory that occur in the hemimetabolous insect Periplaneta americana. Among insects that display considerable longevity, the American cockroach lives up to 64 wk and reveals specific cellular alterations in its mushroom bodies, higher centers that have been shown to be associated with learning and memory. The present results describe a vision-based learning paradigm, based on a modified Barnes maze, that compares memory in young (10-wk old), middle-aged (30-wk old), and aged adults (50-wk old). We show that not only is the performance of this task during the 14 training trials significantly decremented in aged cockroaches, but that aged cockroaches show significant impairment in successfully completing a crucial test involving cue rotation. Light and electron microscopical examination of the brains of these different age groups reveal major changes in neuron morphology and synaptology in the mushroom body lobes, centers shown to underlie place memory in this taxon.

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Section: Aging and The Mushroom Bodymentioning

confidence: 99%

The effect of age on a visual learning task in the American cockroach

Brown

Strausfeld²

2009

Learn. Mem.

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“…The disruption of neuronal calcium homeostasis and consequent molecular events affect neuronal viability and synaptic plasticity and may represent early steps in the development of neuronal degeneration (Foster, 2007). Changes in calcium homeostasis in the brain during aging are thought to be tightly linked to a decline in neuronal performance (Khachaturian, 1989;Verkhratsky and Toescu, 1998).…”

Section: Introductionmentioning

confidence: 99%

Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat

Ouda¹,

Druga²,

Syka³

2008

Experimental Gerontology

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“…An age-related increase in the sAHP has been previously observed in rats, mice, and rabbit hippocampal neurons (Foster, 2007, Landfield and Pitler, 1984, Moyer, et al, 2000, Murphy, et al, 2006. The current that underlies the sAHP in these neurons is sensitive to Ca 2+ with previous experiments showing that blockade of HVA Ca 2+ currents can reverse the age-related sAHP increase Morgan, 1984, Moyer, et al, 1992).…”

Section: Changes To CD 2+ Sensitivity Of Firing Frequency the Sahp mentioning

confidence: 81%

“…Indeed, changes to plasma membrane and sarco-endoplasmic membrane ATPase activity (Jiang, et al, 2012, Michaelis, et al, 1992, voltage gated Ca 2+ channel currents (Campbell, et al, 1996, Frolkis, et al, 1984, Moyer and Disterhoft, 1994, Ca 2+ binding proteins (Verkhratsky and Toescu, 1998) and mitochondrial structure and function have been noted to change with age, some of which can lead to activation of KCa currents (Foster, 2007).…”

Section: Ncx Mode Reversal May Contribute To the Age-related Changes mentioning

confidence: 99%

A switch in the mode of the sodium/calcium exchanger underlies an age-related increase in the slow afterhyperpolarization

Scutt

Allen

Kemenes

et al. 2015

Neurobiology of Aging

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During aging, the Ca 2+ sensitive slow afterhyperpolarization (sAHP) of hippocampal neurons is known to increase in duration. This change has also been observed in the serotonergic cerebral giant cells (CGCs) of the pond snail Lymnaea stagnalis, but has yet to be characterized. In this paper, we confirm that there is a reduction in firing rate, an increase in the duration of the sAHP, and an alteration in the strength and speed of spike frequency adaptation (SFA) in the CGCs during aging, a finding that is compatible with an increase in a sAHP current. We go on to show that age-related changes in the kinetics of SFA are consistent with a reduction in Ca 2+ clearance from the cell, which we confirm with Ca 2+ imaging and pharmacological manipulation of the sodium calcium exchanger (NCX). These experiments suggest that the NCX may be switching to a reverse-mode configuration in the CGCs during aging.3

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Calcium homeostasis and modulation of synaptic plasticity in the aged brain

Abstract: SummaryPhysiological and biological models are outlined, which relate a shift in Ca 2+ regulation with changes in cell excitability and synaptic plasticity, resulting in a functional lesion of the hippocampus.

Cited by 276 publications

References 75 publications

The effect of age on a visual learning task in the American cockroach

The effect of age on a visual learning task in the American cockroach

Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat

A switch in the mode of the sodium/calcium exchanger underlies an age-related increase in the slow afterhyperpolarization

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