Calcium from Finger Millet—A Systematic Review and Meta-Analysis on Calcium Retention, Bone Resorption, and In Vitro Bioavailability

Anitha, S.; Givens, D.I.; Botha, Rosemary; Kane‐Potaka, Joanna; Sulaiman, Nur Liana Binti; Tsusaka, Takuji W.; Subramaniam, Kowsalya; Ananthan, R.; Parasannanavar, Devraj J.; Bhandari, Raj Kumar

doi:10.3390/su13168677

Cited by 23 publications

(29 citation statements)

References 32 publications

(51 reference statements)

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“…Finger millets have a threefold higher concentration of calcium than milk, and calcium retention is higher for finger millet than for any other staple [ 15 ]. Moreover, millets contain more methionine, sulphur amino acids, compared to milled rice and refined wheat [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The findings of this review paper provide scientific evidence supporting diversification of standard diets for children using millets as a solution to malnutrition. Furthermore, millets are a basket of a wide range of nutrients and have been scientifically shown to contribute to serving many of the significant nutrition and health needs globally [ 12 , 13 , 14 , 15 ], not only by tackling child undernutrition, but also by managing type 2 diabetes [ 12 ], lowering total cholesterol levels, obesity [ 13 ], and iron deficiency anaemia [ 14 ]. To bring this solution to reality, awareness about the nutritional value is needed to drive demand and investments in millets along the value chain, from fork to farm.…”

Section: Discussionmentioning

confidence: 99%

“…The year 2023 has been approved by the United Nations as the International Year of Millets, which is expected to attract major attention to millets. Previous systematic reviews and meta-analyses conducted on millets’ health and nutritional benefits showed that regular consumption of millets could help manage the risk of developing type 2 diabetes [ 12 ], reduce hyperlipidaemia, hypertension, and body mass index (BMI), thereby helping manage cardiovascular disease risk [ 13 ], improve haemoglobin level, and reduce anaemia [ 14 ], as well as helping calcium retention [ 15 ]. However, scientific evidence of millets’ role in addressing global crises, such as impaired growth, has had fewer studies undertaken in order to prioritize these crops in nutritional interventions.…”

Section: Introductionmentioning

confidence: 99%

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Can Feeding a Millet-Based Diet Improve the Growth of Children?—A Systematic Review and Meta-Analysis

et al. 2022

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Undernutrition, such as stunting and underweight, is a major public health concern, which requires multi-sectoral attention. Diet plays a key role in growth and should optimally supply all required nutrients to support the growth. While millets (defined broadly to include sorghum) are traditional foods, and climate smart nutritious crops, which are grown across Africa and Asia, they have not been mainstreamed like rice, wheat, and maize. Diversifying staples with millets can potentially provide more macro and micro nutrients, compared to the mainstream crops. However, there is little known scientific evidence to prove millets’ efficacy on growth. Therefore, a systematic review and meta-analysis was conducted to collate evidence of the benefits of millets in improving the growth of children. Eight eligible randomized feeding trials were included in the meta-analysis. Results from the randomized effect model showed a significant effect (p < 0.05) of millet-based diets on mean height (+28.2%) (n = 8), weight (n = 9) (+26%), mid upper arm circumference (n = 5) (+39%) and chest circumference (n = 5) (+37%) in comparison to regular rice-based diets over for the period of 3 months to 4.5 years, which was based on largely substituting rice with millets. When an enhanced and diverse diet was served, replacing rice with millet had only minimal growth improvement on chest circumference (p < 0.05). The quality assessment using GRADE shows that the evidence used for this systematic review and meta-analysis had moderate quality, based on eight scoring criteria. These results demonstrate the value of adding millet as the staple for undernourished communities. Further understanding of the efficacy of millets on growth in a wider range of diets is important to develop appropriate dietary programs and improve the nutritional status of various age groups across Africa and Asia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can Feeding a Millet-Based Diet Improve the Growth of Children?—A Systematic Review and Meta-Analysis

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“…Moreover, they can also be used as antioxidants and anti-inflammatories in health care or natural iron supplements for their enrichment in iron. 26,27 Recently, the sequence of ferritin from S. italica was identified. 28 To date, no one ferritin crystal structure from a monocot has been solved, and whether the EPs from these species adopt the same folding pattern as we saw in SFER4 and UpFer remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Extension Peptide of Plant Ferritin from Setaria italica Presents a Novel Fold

Wang

et al. 2022

J. Agric. Food Chem.

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The extension peptide (EP) is the most distinctive feature of mature plant ferritin. Some EPs have exhibited serinelike protease activity, which is associated with iron uptake and release. EP forms a helix and a long loop, followed by a conserved core helical bundle. However, whether the EP adopts a stable or uniform folding pattern in all plants remains unclear. To clarify this, we investigated the crystal structure of ferritin-1 from Setaria italica (SiFer1), a type of monocotyledon. In our structure of SiFer1, the EP is different from other EPs in other solved structures of plant ferritins and consisted of a pair of β-sheets, a shorter helix, and two loops, which masks two hydrophobic pockets on the outer surface of every subunit. Furthermore, sequence analysis and structure comparison suggest that the EPs in ferritins from monocotyledons may adopt a novel fold pattern, and the conformations of EPs in ferritins are alterable among different plant species. Furthermore, additional eight iron atoms were first founded binding in the fourfold channels, demonstrating the vital function of fourfold channels in iron diffusion. In all, our structure provides new clues for understanding plant ferritins and the functions of the EP.

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“…It is a rich source of phosphorus, iron, magnesium, calcium, and fiber [ 12 ]. Finger millet has 5–30 times more calcium than other grains [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Physical Activity and Finger Millet-Based Food Supplement on Biochemical Parameters and Bone Mineral Density among Premenopausal Women

Rani

Swaminathan

Vijayaraghavan

2021

Evidence-Based Complementary and Alternative Medicine

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The effectiveness of physical activity and finger millet-based food supplement on biochemical parameters and bone mineral density (BMD) among premenopausal women were studied. Serum calcium, phosphorus, alkaline phosphatase, and BMD of 720 women (30–40 years) were analyzed. From them, 150 women with low BMD (t-score, −1 to −2.5) and low calcium (<9.0 mg/dL) were randomized to control and experimental groups, equally. The experimental group was given 5 days per week physical activity, for 3 months, and a diet supplement of finger millet-based sweet balls (ragi laddu), 3 days per week for 3 months. The above parameters were measured as the posttest. Physical activity was assessed by the General Practice Physical Activity Questionnaire. A 24 h recall assessment was carried out for the diet supplement, and self-reported activity checklist was maintained for physical activity. Among 720 women, 163 (22.6%) showed BMD, t-score < −1.0, and calcium <9.0 mg/dL p < 0.001 . The serum phosphorus and alkaline phosphatase were also low p < 0.001 . After the supplementation to the experimental group, all the biochemical parameters, BMD, and physical activity score showed significant improvement in the posttest p < 0.001 . This study showed significantly low BMD and calcium among premenopausal women. Physical activity and finger millet supplement improved the calcium level and BMD.

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Calcium from Finger Millet—A Systematic Review and Meta-Analysis on Calcium Retention, Bone Resorption, and In Vitro Bioavailability

Cited by 23 publications

References 32 publications

Can Feeding a Millet-Based Diet Improve the Growth of Children?—A Systematic Review and Meta-Analysis

Can Feeding a Millet-Based Diet Improve the Growth of Children?—A Systematic Review and Meta-Analysis

Extension Peptide of Plant Ferritin from Setaria italica Presents a Novel Fold

Effectiveness of Physical Activity and Finger Millet-Based Food Supplement on Biochemical Parameters and Bone Mineral Density among Premenopausal Women

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