Calcium Dynamics and Cardiac Arrhythmia

Deo, M. C.; Weinberg, Seth H.; Boyle, Patrick

doi:10.1177/1179546817739523

Cited by 12 publications

(9 citation statements)

References 38 publications

(19 reference statements)

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“…Calcium ions play an essential role not only in myocardial contraction but also in the occurrence of arrhythmia. 32 , 33 Acidemia increases extracellular H + level and then promotes the exchange between the extracellular H + and intracellular Ca 2+ , decreasing the intracellular Ca 2+ levels and reduces the contractility of the heart muscle, finally leads to hypoinfusion of vital organs. Besides, H + -Ca 2+ exchange promotes Ca 2+ translates into cell, shortening the second stages and the whole action potential, finally increases the risk of arrhythmia.…”

Section: Discussionmentioning

confidence: 99%

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Zhang

Guan

Líu

2020

Clin Appl Thromb Hemost

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Acute myocardial infarction (AMI) is a leading cause of death and not a few of these patients are combined with acidemia. This study aimed to detect the association of acidemia with short-term mortality of AMI patients. A total of 972 AMI patients were selected from the Medical Information Mart for Intensive Care (MIMIC) III database for analysis. Propensity-score matching (PSM) was used to reduce the imbalance. Kaplan-Meier survival analysis was used to compare the mortality, and Cox-proportional hazards model was used to detect related factors associated with mortality. After PSM, a total of 345 non-acidemia patients and 345 matched acidemia patients were included. The non-acidemia patients had a significantly lower 30-day mortality (20.0% vs. 28.7%) and lower 90-day mortality (24.9% vs. 31.9%) than the acidemia patients ( P < 0.001 for all). The severe-acidemia patients (PH < 7.25) had the highest 30-day mortality (52.6%) and 90-day mortality (53.9%) than non-acidemia patients and mild-acidemia (7.25 ≤ PH < 7.35) patients ( P < 0.001). In Cox-proportional hazards model, acidemia was associated with improved 30-day mortality (HR = 1.518; 95%CI = 1.110-2.076, P = 0.009) and 90-day mortality (HR = 1.378; 95%CI = 1.034 -1.837, P = 0.029). These results suggest that severe acidemia is associated with improved 30-day mortality and 90-day mortality of AMI patients.

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Section: Discussionmentioning

confidence: 99%

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Zhang

Guan

Líu

2020

Clin Appl Thromb Hemost

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“…The tube formation of HUVEC cells was facilitated by exosomes from nonirradiated hp-MSCs, but not the irradiated hp-MSCs. The homeostasis of calcium transient is a crucial factor for maintaining normal cardiac rhythm (27). Following ischemia/reperfusion injury, the internal levels of calcium in H9c2 cells increased in a time-dependent manner (28), and calcium overload in H9c2 cells may further accelerate reperfusion injury (29).…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells-derived Exosomes as Probable Triggers of Radiation-induced Heart Disease

Luo¹,

Chang²,

Fuchi³

et al. 2021

Preprint

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Background: Radiation-induced heart disease have been reported, but the mechanisms remain unclear. Mesenchymal stem cells (MSCs), also resident in heart are highly susceptible to radiation. We examined the hypothesis that altered secretion of exosomes from MSCs as the triggers of radiation-induced heart disease. Methods: By exposing human placental tissue-derived MSCs to 5 Gy γ-rays, we will then isolate exosomes from the culture medium 48h later and use to evaluate the quantity and quality changes of exosomes from MSCs after radiation exposures. The biological effects of exosomes from irradiated MSCs on HUVEC and H9c2 cells were also examined. Results: Although the amount and size distribution of exosomes did not differ between the non-irradiated and irradiated MSCs, miRNA sequences indicated many up- or down-regulated miRNAs in irradiated MSCs-exosomes. In vitro experiments using HUVEC and H9c2 cells showed that irradiated MSCs-exosomes significantly decreased cell proliferation, but increased cell apoptosis and DNA damage. Moreover, irradiated MSCs-exosomes impaired the tube formation of HUVEC cells and induced calcium overload of H9c2 cells. Conclusions: Exosomes released from irradiated MSCs shows an altered miRNA profiling and harmful effect to damage heart cells, which provides new insight on the mechanism of radiation-related heart disease risks.

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“…Early afterdepolarizations are a consequence of untimely LTCC reopening and delayed afterdepolarizations occur because of Ca 2+ leaks from the sarcoplasmic reticulum and subsequent substitution of 1 Ca 2+ ion for 3 Na + ions by the NCX. 34,[47][48][49] The major role of Ca 2+ ions in the processes of myocardial contraction and relaxation suggests that a reasonable use of Ca 2+ salts to increase the concentration of these ions on both sides of sarcolemma may cause positive inotropic and chronotropic effects. Indeed, it is a common practice among cardiac anesthesiologists to administer CaCl 2 during weaning from CPB in order to improve cardiac contractility.…”

Section: Ca 2+ Homeostasis and Role In Excitation-contraction Couplinmentioning

confidence: 99%

Calcium Administration During Weaning From Cardiopulmonary Bypass: A Narrative Literature Review

Ломиворотов

Leonova

Belletti

et al. 2020

Journal of Cardiothoracic and Vascular Anesthesia

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Calcium Dynamics and Cardiac Arrhythmia

Abstract: This Special Collection will gather all studies highlighting recent advances in theoretical and experimental studies of arrhythmia, with a specific focus on research seeking to elucidate links between calcium homeostasis in cardiac cells and organ-scale disruption of heart rhythm.

Cited by 12 publications

References 38 publications

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Association of Acidemia With Short-Term Mortality of Acute Myocardial Infarction: A Retrospective Study Base on MIMIC-III Database

Mesenchymal Stem Cells-derived Exosomes as Probable Triggers of Radiation-induced Heart Disease

Calcium Administration During Weaning From Cardiopulmonary Bypass: A Narrative Literature Review

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