Calcium Disorders

Green, Todd A.; Chew, Dennis J.

doi:10.1016/b978-1-4557-0306-7.00052-0

Cited by 3 publications

(1 citation statement)

References 15 publications

(17 reference statements)

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“…PCT is the precursor of the hormone calcitonin. In health, PCT is produced by the parafollicular (C) cells in the thyroid gland and converted to calcitonin in response to increased plasma calcium concentrations 10 11. In healthy people, plasma PCT concentrations are typically below the level of detection of clinical assays (<10 pg/ml) 12.…”

Section: Introductionmentioning

confidence: 99%

Plasma procalcitonin concentrations are increased in dogs with sepsis

Goggs

Milloway

Troìa

et al. 2018

Veterinary Record Open

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Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome. Before analysing canine plasma samples, the ability of the assay to identify canine PCT, in addition to assay imprecision and the lower limit of detection were established. The assay had low imprecision with coefficients of variation ≤4.5 per cent. The lower limit of detection was 3.4 pg/ml. Plasma PCT concentrations were measured in 20 dogs with sepsis, in 32 dogs with GDV syndrome and in 52 healthy dogs. Median (IQR) PCT concentration in dogs with sepsis 78.7 pg/ml (39.1–164.7) was significantly greater than in healthy dogs 49.8 pg/ml (36.2–63.7) (P=0.019), but there were no significant differences between PCT concentrations in dogs with GDV syndrome and controls (P=0.072) or between dogs with sepsis and GDV syndrome (P=1.000). Dogs with sepsis have significantly increased plasma PCT concentrations compared with healthy dogs, although considerable overlap between these populations was identified. Future investigations should confirm this finding in other populations and evaluate the diagnostic and prognostic value of PCT in dogs with sepsis.

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Section: Introductionmentioning

confidence: 99%

Plasma procalcitonin concentrations are increased in dogs with sepsis

Goggs

Milloway

Troìa

et al. 2018

Veterinary Record Open

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Massive Transfusion

Beer

Thomer

2018

Textbook of Small Animal Emergency Medicine

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The highs and lows of electrolytes part 2: calcium, phosphate and magnesium

Anderson

2021

The Veterinary Nurse

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There are six electrolytes that are important in maintaining homeostasis within the body. They play vital roles in regulating neurological, myocardial, muscular and cellular functions and are involved in fluid and acid–base balance. Recognising and treating electrolyte derangements is an important role for veterinary nurses especially in emergency and critical care patients. This series of two articles will discuss the physiology behind each of the six major electrolytes and discuss to monitor and treat any abnormalities.

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Calcium Disorders

Cited by 3 publications

References 15 publications

Plasma procalcitonin concentrations are increased in dogs with sepsis

Plasma procalcitonin concentrations are increased in dogs with sepsis

Massive Transfusion

The highs and lows of electrolytes part 2: calcium, phosphate and magnesium

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