Calcium Disodium Edathamil in the Treatment of Ferrous Sulfate Poisoning

Barrie, Herbert

doi:10.1001/jama.1962.03050160060021a

Search citation statements

Order By: Relevance

Paper Sections

Select...

The Polyaminocarboxylic Acids1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1963

1983

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 8 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EDTA and the other polyaminocarboxylic acids are used in the treatment of poisoning due to a number of metals, including cadmium (19), iron (20,21), and manganese (22). These chelating agents are the treatment of choice for lead poisoning in the United States.…”

Section: The Polyaminocarboxylic Acidsmentioning

confidence: 99%

Therapeutic chelating agents

Jones¹,

Pratt²

1976

J. Chem. Educ.

View full text Add to dashboard Cite

Section: The Polyaminocarboxylic Acidsmentioning

confidence: 99%

Therapeutic chelating agents

Jones¹,

Pratt²

1976

J. Chem. Educ.

View full text Add to dashboard Cite

Acute Iron Intoxication

Santos¹,

Pisciotta²

1964

Am J Dis Child

View full text Add to dashboard Cite

Many physicians are not aware of the seriousness of poisoning with the ferrous and ferric salts of iron. At the turn of the century, before iron therapy became widespread, there were few reports of iron intoxication. However, with the increased clinical use of iron, there has been an alarming increase in the incidence of iron toxicity.One of the first of these was the report by Forbes, in 1947,1 of two fatal cases of ferrous sulfate poisoning in children. In Great Britain, iron is considered the most important single cause of poisoning in children.2 Cumulative experience discloses close to 50% mortality in dosage ranges from 2 to 4 gm of orally ingested iron 3 in children. Because of the high mortality rate associated with iron toxicity, a more effective form of treatment is required. A number of approaches have been directed toward chelation of free iron in order to facilitate its excretion as a harmless chelated salt. These include ethelene-diaminetetraacetic acid,2'4,5 dimercaprol (British anti-lewisite [BAL]),6 and others.7 Most recently, another chelating agent, Ba-29837 * has been used with con¬ siderable success in experimental iron in¬ toxication in guinea pigs 8 and in hemosidero¬ sis and hemochromatosis in man.8·* It is the purpose of this paper to present an instance of iron toxicity in a child, successfully man¬ aged with Ba-29837. As far as we know, this is the first report of the use of this drug in a human.

show abstract