Calcium-dependent release of putative neurotransmitters in the chick visual system

Bondy, Stephen C.; Harrington, Marilyn E.

doi:10.1016/0306-4522(79)90057-5

Cited by 6 publications

(4 citation statements)

References 43 publications

(39 reference statements)

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“…We are not able to draw any firm conclusions about the site of EDA uptake, storage or release, as a calcium-dependent release of GABA has been reported from some glial cells (Minchin and Iversen, 1974) and nonsynaptic regions of nerve (Bondy and Harrington, 1979). However, release was evoked in such cases by potassium depolarisation, and we would suggest that the present demonstration of calcium-dependent release of EDA produced by electrical stimulation is more likely to imply neuronal, rather than glial involvement.…”

Section: H G E Lloyd Et Alcontrasting

confidence: 72%

Uptake and Calcium‐Dependent Release of Ethylenediamine (1,2‐Diaminoethane) by Rat Brain Slices

Lloyd

Perkins

Gaitonde

et al. 1982

Journal of Neurochemistry

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The uptake of [14C]ethylenediamine into slices of rat brain and its subsequent evoked release have been studied. An active uptake process was demonstrated by comparing uptake at 37 and 4 degrees C. This uptake showed a Km of 1.36 mM, was partly sodium-dependent and was reduced by nipecotic acid. Release could be readily evoked by 30 mM potassium, and by electrical stimulation, the release in both cases being calcium-dependent. In view of these findings and the reported interactions of ethylenediamine with gamma-aminobutyric acid-related mechanisms, it might be of interest to determine whether this simple diamine occurs endogenously in the mammalian brain.

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Section: H G E Lloyd Et Alcontrasting

confidence: 72%

Uptake and Calcium‐Dependent Release of Ethylenediamine (1,2‐Diaminoethane) by Rat Brain Slices

Lloyd

Perkins

Gaitonde

et al. 1982

Journal of Neurochemistry

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“…Where indicated, aCSF was altered by lowering Ca 2 + and increasing Mg 2 + to either 0.5 mM Ca 2 + /10 mM Mg 2 + (Media-1) or 0.25 mM Ca 2 + /7.25 mM Mg 2 + (Media-2). Flow rates were kept at 2 ml/min to insure adequate infusion of the altered media, consistent with previous published studies (Bondy and Harrington, 1979;Washio and Inouye, 1978;Alderdice and Volle, 1978;Scholfied, 1981). Incubation with such media for 5 min or greater has been shown to block synaptic transmission (Bondy and Harrington, 1979;Washio and Inouye, 1978;Alderdice and Volle, 1978;Scholfied, 1981;Hutter and Kostial, 1954).…”

Section: In Vitro Extracellular Electrophysiologymentioning

confidence: 92%

“…Flow rates were kept at 2 ml/min to insure adequate infusion of the altered media, consistent with previous published studies (Bondy and Harrington, 1979;Washio and Inouye, 1978;Alderdice and Volle, 1978;Scholfied, 1981). Incubation with such media for 5 min or greater has been shown to block synaptic transmission (Bondy and Harrington, 1979;Washio and Inouye, 1978;Alderdice and Volle, 1978;Scholfied, 1981;Hutter and Kostial, 1954). Extracellular electrophysiological recordings were made with glass microelectrodes filled with a solution of 2% pontamine sky-blue in 0.5 M sodium acetate (Yin and French, 2000).…”

Section: In Vitro Extracellular Electrophysiologymentioning

confidence: 92%

The Abused Inhalant Toluene Increases Dopamine Release in the Nucleus Accumbens by Directly Stimulating Ventral Tegmental Area Neurons

Riegel

Zapata

Shippenberg

et al. 2007

Neuropsychopharmacol

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Recreational abuse of toluene-containing volatile inhalants by adolescents is a significant public health problem. The mechanisms underlying the abuse potential of such substances remain unclear, but could involve increased activity in mesoaccumbal dopamine (DA) afferents innervating the nucleus accumbens (ACB). Here, using in vitro electrophysiology, we show that application of behaviorally relevant concentrations of toluene directly stimulates DA neurons in the ventral tegmental area (VTA), but not surrounding midbrain regions. Toluene stimulation of VTA neurons persists when synaptic transmission is reduced. Moreover, unlike non-DA neurons, the magnitude of VTA DA neuron firing does not decline during longer exposures designed to emulate 'huffing'. Using dual-probe in vivo microdialysis, we show that perfusion of toluene directly into the VTA increases DA concentrations in the VTA (somatodendritic release) and its terminal projection site, the ACB. These results provide the first demonstration that even brief exposure to toluene increases action potential drive onto mesoaccumbal VTA DA neurons, thereby enhancing DA release in the ACB. The finding that toluene stimulates mesoaccumbal neurotransmission by activating VTA DA neurons directly (independently of transynaptic inputs) provide insights into the neural substrates that may contribute to the initiation and pathophysiology of toluene abuse.

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“…The importance of GABA as tectal transmitter is demonstrated by biochemical, histochemical, and electrophysiological data. A GABA high-affinity uptake system (Henke et al, 1976~1, muscimol binding sites (Vischer e t al., 19791, and a potassium-stimulated, calcium-dependent, release of GABA in vitro (Reubi and Cuenod, 1976;Bondy and Harrington, 1979) in the tectum have been reported. The activity of tectal neurons is inhibited by iontophoretically applied GABA; this inhibition can be blocked selectively with bicuculline (Barth and Felix, 1974;Felix et al, 1975;Felix, 1982).…”

Section: F Fonnum a N D H Henkementioning

confidence: 95%

The Topographical Distribution of Alanine, Aspartate, γ‐Aminobutyric Acid, Glutamate, Glutamine, and Glycine in the Pigeon Optic Tectum and the Effect of Retinal Ablation

Fonnum¹,

Henke²

1982

Journal of Neurochemistry

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The concentrations of alanine, aspartate, γ‐aminobutyric acid, glutamine, glutamate, and glycine were measured in the pigeon optic nerve and in the individual tectal layers. Characteristic topographical distribution patterns were observed for the different amino acids. After unilateral retinal ablation, the concentration of aspartate and glutamate was decreased in the nerve and contralateral tectum. The reduction was restricted to the superficial part of the tectum, which receives a direct retinal input. The maximal loss was measured in the first two layers, where aspartate was reduced by 51% and glutamate by 75% in comparison with the ipsilateral side 4 weeks after ablation. The results favor a special role for aspartate and glutamate in pigeon retino‐tectal afferents.

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Calcium-dependent release of putative neurotransmitters in the chick visual system

Cited by 6 publications

References 43 publications

Uptake and Calcium‐Dependent Release of Ethylenediamine (1,2‐Diaminoethane) by Rat Brain Slices

Uptake and Calcium‐Dependent Release of Ethylenediamine (1,2‐Diaminoethane) by Rat Brain Slices

The Abused Inhalant Toluene Increases Dopamine Release in the Nucleus Accumbens by Directly Stimulating Ventral Tegmental Area Neurons

The Topographical Distribution of Alanine, Aspartate, γ‐Aminobutyric Acid, Glutamate, Glutamine, and Glycine in the Pigeon Optic Tectum and the Effect of Retinal Ablation

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