“…They play a prominent role in initiating action-potential-evoked neurotransmitter release both at peripheral neuromuscular junctions and central synapses, mainly within the cerebellum, brainstem, and cerebral cortex (Katz et al 1996, Catterall 1998, Iwasaki et al 2000. Even when pharmacological and electrophysiological studies in brain slices from rodents have revealed that P/Q-, N-and R-type channels cooperate in controlling release at many central excitatory synapses, P/Q-type channels have a dominant role, partly because of their more efficient coupling to the exocytotic machinery (González Inchauspe et al 2004, Li et al 2007, Matsushita et al 2002, Qian and Noebels 2001, 2000, Wu et al 1999, Mintz et al 1995.…”