1995
DOI: 10.1016/0896-6273(95)90155-8
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Calcium control of transmitter release at a cerebellar synapse

Abstract: The manner in which presynaptic Ca2+ influx controls the release of neurotransmitter was investigated at the granule cell to Purkinje cell synapse in rat cerebellar slices. Excitatory postsynaptic currents were measured using whole-cell voltage clamp, and changes in presynaptic Ca2+ influx were determined with the Ca(2+)-sensitive dye furaptra. We manipulated presynaptic Ca2+ entry by altering external Ca2+ levels and by blocking Ca2+ channels with Cd2+ or with the toxins omega-conotoxin GVIA and omega-Aga-IVA… Show more

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Cited by 485 publications
(546 citation statements)
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“…Calcium channels containing the 1A subunit (Ca V 2.1 or P/Q-type) are expressed throughout the human and mammalian brain with a higher concentration in the cerebellum and are localized in most presynaptic terminals (Catterall 1998, Wu et al 1999, Mintz et al 1995 as well as in the cell body and dendrites of many neurons (Volsen et al 1995, Westenbroek et al 1995. In many central synapses, Ca V 2.1 channels are preferentially located at the release sites and are more effectively coupled to neurotransmitter release than other Ca 2+ channel types (Li et al 2007, Matsushita et al 2002, Qian and Noebels 2001, 2000, Dunlap et al 1995, Mintz et al 1995, Wu et al 1999, Iwasaki et al 2000.…”
Section: Discussionmentioning
confidence: 99%
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“…Calcium channels containing the 1A subunit (Ca V 2.1 or P/Q-type) are expressed throughout the human and mammalian brain with a higher concentration in the cerebellum and are localized in most presynaptic terminals (Catterall 1998, Wu et al 1999, Mintz et al 1995 as well as in the cell body and dendrites of many neurons (Volsen et al 1995, Westenbroek et al 1995. In many central synapses, Ca V 2.1 channels are preferentially located at the release sites and are more effectively coupled to neurotransmitter release than other Ca 2+ channel types (Li et al 2007, Matsushita et al 2002, Qian and Noebels 2001, 2000, Dunlap et al 1995, Mintz et al 1995, Wu et al 1999, Iwasaki et al 2000.…”
Section: Discussionmentioning
confidence: 99%
“…In many central synapses, Ca V 2.1 channels are preferentially located at the release sites and are more effectively coupled to neurotransmitter release than other Ca 2+ channel types (Li et al 2007, Matsushita et al 2002, Qian and Noebels 2001, 2000, Dunlap et al 1995, Mintz et al 1995, Wu et al 1999, Iwasaki et al 2000. At these synapses, the action potential-evoked Ca 2+ influx and the local Ca 2+ increase that triggers neurotransmitter release are mainly determined by the kinetics of opening and closing, the open probability and the unitary conductance of Ca V 2.1 channels (Borst and Sakmann 1998, Sabatini and Regehr 1999, Meinrenken et al 2002, 2003.…”
Section: Discussionmentioning
confidence: 99%
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“…Many well-studied CNS synapses exhibit a roughly third-order relationship between Ca 2+ influx and release (Mintz et al, 1995;Borst and Sakmann, 1999b;Wu et al, 1999). In contrast, at rod photoreceptor terminals, there is a linear relationship between the magnitude of I Ca and exocytosis .…”
Section: Linearity Between Ca 2+ Influx and Exocytosis: Mechanistic Imentioning
confidence: 99%