Calcium Citrate and Vitamin D in the Treatment of Osteoporosis

Gómez, José Manuel; Rubió, Josep Blanch; Curiel, Manuel Dı́az; Pérez, Adolfo Díez

doi:10.1007/bf03256927

Cited by 25 publications

(7 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Based on a consensus, the effectiveness of anti-resorptive treatment by bisphosphonates in OP depends on the presence of a su cient serum level of vitamin D and enough calcium in diet (5). Supplementation with a combination of calcium and vitamin D3 (cholecalciferol) has long been suggested as potentially successful in reducing the de ciency, and can serve as a fundamental therapeutic regimen in the primary and secondary prevention and treatment of OP in order to increase bone mineral density (BMD) and reduce the risk of fall and, consequently, osteoporotic fractures (5,(10)(11)(12). Some other recent clinical results did not fully support this theory and stated that higher doses of vitamin D administration with or without calcium may not be effective in increasing BMD; it had no bene t on lower extremity function, was associated with an increased risk of fall, and was not able to reduce the risk of progression in OP.…”

Section: Treatment Of Osteoporosismentioning

confidence: 99%

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

Mirani,

Horváth,

Vecsernyés

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Calcium intake is an essential component of a healthy diet and has been linked to numerous health benefits, including the prevention of osteoporosis and reduction of fracture risk in children and adults. The most plausible consequence of insufficient calcium intake can lead to osteoporosis over decades, which is a significant cause of morbidity and mortality with high burden of disease. However, attention should be given to the risk of potential overdoses, since some trials have linked excessive calcium supplementation to increased risk of health complications.Methods Our study aimed to evaluate the possible factors influencing the participants’ calcium profile through a “dietary intake specific questionnaire” to achieve the optimal calcium and vitamin D intake in the prevention of or during therapies for osteoporosis. A comprehensive multi-dimensional dietary survey was administered to evaluate various aspects of the participants' diets, including dietary and supplemented calcium intake, vitamin D exposure, vitamin supplementation profile, and relevant lifestyle parameters. In this article, we specifically analyzed the calcium intake profiles and pharmacovigilance aspects of the study participants.Results We received 478 evaluable datasets. The dietary calcium intake, on average, was close to optimal in the general public. Supplementation safety concerns were raised for the public in less than 7% of patients, who were reported to have a potential overload in daily calcium intake. Albeit, one-third (34%) of the population had a significant deficiency (average: 544 mg/day), and this effect was more relevant among ≤ 25-years old individuals, of them only less than 37% of the responders had an optimal calcium intake. More than half (52%) of the dietary calcium deficient participants did not take any additional calcium supplements. Although, in 73% of general population, most calcium supplementation dosage in use was equal to or below 200 mg/day.Conclusion Our study highlights the importance to implement a “Patient Focused Motivation Strategy” as a broader approach in pharmaceutical care for increasing the patient’s knowledge, understanding the needs of supplementation, and selecting the correct form and dose of the available non-prescription products. It is important to maintain motivation and adherence to the recommended therapy to achieve optimal health outcomes.

show abstract

Section: Treatment Of Osteoporosismentioning

confidence: 99%

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

Mirani,

Horváth,

Vecsernyés

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Calcium supplementation, guaranteeing a daily dose intake within a range of 700-1,500 mg, is strongly re commended by American and European taskforces in subjects affected by osteopenia, osteoporosis or at risk of calcium deficiency [13,50].…”

Section: Calcium Supplementation In Ankylosing Spondylitis Patients -mentioning

confidence: 99%

Calcium physiology, metabolism and supplementation: a glance at patients with ankylosing spondylitis

Talotta¹,

Rucci²,

Scaglione³

2020

Reumatologia

View full text Add to dashboard Cite

The aim of this review is to describe the metabolism of calcium in ankylosing spondylitis compared to physiologic conditions, and to present the current evidence on the benefits and disadvantages of calcium supplementation in these patients. A narrative review of the literature was conducted using the PubMed database and a total of 65 articles were selected. Calcium is involved in many physiopathological processes, including inflammation, bone loss and bone formation, all of which occur in ankylosing spondylitis. Many ankylosing spondylitis patients suffer from concomitant osteopenia or osteoporosis, which represent indications for calcium supplementation. Conversely, there are still concerns about the use of calcium salts for the prevention of bone fragility in non-osteoporotic or non-osteopenic patients. <br /> In these cases, biologic agents may indirectly normalize calcium dysmetabolism by rebalancing the cytokine milieu, in turn associated with bone remodeling. Calcium supplements may be disadvantageous for entheseal calcifications, but so far there are no clear data confirming that such an association exists.

show abstract

“…Mikronutrien yang paling berperan pada homeostasis mineral tulang adalah kalsium dan vitamin D. (8) Penggunaan obat kortikosteroid jangka panjang, merokok, asupan alkohol dan kafein juga menjadi faktor yang memudahkan terjadinya osteoporosis. (9) Kesehatan tulang ditentukan dari kepadatan tulang dan kualitas tulang. Kepadatan tulang menunjukkan jumlah gram mineral per volume tulang, yang dapat dinilai dengan BMD.…”

Section: Abstract Pendahuluanunclassified

Aktivitas berjalan meningkatkan bone mineral density pada perempuan pascamenopause

Savitri¹,

Herwana²

2020

J Biomedika Kesehat

View full text Add to dashboard Cite

LATAR BELAKANGOsteoporosis merupakan penyakit tulang yang ditandai dengan rendahnya bone mineral density (BMD) disertai perubahan pada mikroarsitektur tulang. BMD yang rendah menandai adanya penurunan kepadatan pada tulang dan meningkatkan risiko terjadinya fraktur. Penurunan kadar estrogen pada kondisi pascamenopause, gaya hidup yang meliputi aktivitas fisik dan kebiasaan berjalan sangat berperanan dalam progresivitas osteoporosis. Penelitian ini bertujuan menilai hubungan antara aktivitas berjalan dengan kepadatan tulang pada perempuan pascamenopause. METODEPenelitian analitik observasional dengan metode cross-sectional dilakukan pada perempuan pascamenopause berusia 45-70 tahun pada periode Agustus-Oktober 2018. Penilaian aktivitas berjalan dilakukan dengan menggunakan kuesioner dan wawancara. Aktivitas berjalan dinilai dari jumlah langkah berjalan/hari yang dikonversikan dari jarak tempuh subjek berjalan kaki setiap harinya. Pengukuran BMD menggunakan calcaneal quantitative ultrasound (QUS), hasil pengukuran BMD membedakan kepadatan tulang berdasarkan nilai-T. Analisis data dilakukan dengan uji statistik Chi Square dengan tingkat kemaknaan p<0.05. HASILSebanyak 88 perempuan pascamenopause ikut berpartisipasi sebagai subjek penelitian dengan usia (rerata ± simpang baku) 57.91 ± 7.25 tahun. Distribusi aktivitas berjalan didapatkan 71 (80.7%) kurang aktif, 12 (13.6%) aktivitas sedang, dan 5 (5.7%) aktif. Distribusi hasil penilaian kepadatan tulang didapatkan sebanyak 18 (20.5%) normal, 49 (55.75%) osteopenia dan 21 (23.9%) osteoporosis. Hasil analisis statistik menunjukkan terdapat hubungan yang bermakna antara aktivitas berjalan dan kepadatan tulang pada perempuan pascamenopause (p=0.009). KESIMPULANTerdapat hubungan yang bermakna antara aktivitas berjalan dan kepadatan tulang pada perempuan pascamenopause.

show abstract

Calcium Citrate and Vitamin D in the Treatment of Osteoporosis

Cited by 25 publications

References 83 publications

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

Risk-Benefits Assessment of Calcium Supplementation Based on Multi- Dimensional Nutritional Profiles in the Hungarian Population

Calcium physiology, metabolism and supplementation: a glance at patients with ankylosing spondylitis

Aktivitas berjalan meningkatkan bone mineral density pada perempuan pascamenopause

Contact Info

Product

Resources

About