Calcium channels linked to altered cellular function and disease

Mader, Theresa; Liu, Zhengye; Lanner, Johanna T.

doi:10.1016/j.cophys.2020.07.010

Cited by 1 publication

(1 citation statement)

References 186 publications

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“…Zinc deficiency is prevalent in developing countries and has been implicated in the growth retardation of up to two billion people, as well as approximately 800,000 child deaths per year [ 6 , 11 ]. Calcium is the most abundant mineral in the body and accounts for 1.5–2.2% of total body weight; it is involved in skeletal strength maintenance, muscle contraction, neurotransmission, and blood coagulation [ 5 , 12 , 13 ]. Calcium deficiency results in a reduction in bone mass and bone-related illnesses, such as osteoporosis and rickets, especially in children and older adults [ 5 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Peptide–Mineral Complexes: Understanding Their Chemical Interactions, Bioavailability, and Potential Application in Mitigating Micronutrient Deficiency

Sun

Sarteshnizi

Boachie

et al. 2020

Foods

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Iron, zinc, and calcium are essential micronutrients that play vital biological roles to maintain human health. Thus, their deficiencies are a public health concern worldwide. Mitigation of these deficiencies involves micronutrient fortification of staple foods, a strategy that can alter the physical and sensory properties of foods. Peptide–mineral complexes have been identified as promising alternatives for mineral-fortified functional foods or mineral supplements. This review outlines some of the methods used in the determination of the mineral chelating activities of food protein-derived peptides and the approaches for the preparation, purification and identification of mineral-binding peptides. The structure–activity relationship of mineral-binding peptides and the potential use of peptide–mineral complexes as functional food ingredients to mitigate micronutrient deficiency are discussed in relation to their chemical interactions, solubility, gastrointestinal digestion, absorption, and bioavailability. Finally, insights on the current challenges and future research directions in this area are provided.

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