Calcium Channels in Vascular Smooth Muscle

Ghosh, Debapriya; Syed, Arsalan U.; Prada, Maria Paz; Nystoriak, Matthew A.; Santana, Luis Fernando; Nieves‐Cintrón, Madeline; Navedo, Manuel F.

doi:10.1016/bs.apha.2016.08.002

Cited by 89 publications

(81 citation statements)

References 195 publications

(276 reference statements)

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“…Functional TRP channels are composed of four subunits, each with six membrane-spanning helices that can exist in a homomeric or heteromeric form. Vascular smooth muscle cells express a number of these channels, including members of the TRPC, TRPV, TRPM, and TRPP subfamilies [7,9]. The function of TRP channels in vascular smooth muscle ranges from regulating contractility to modulating the proliferative state of the cells.…”

Section: Trp Channelsmentioning

confidence: 99%

“…PKC activity inhibits TRPC3 channels and activates TRPM4 and TRPV4 channels in smooth muscle [7,9,21,24]. TRPM4 activation by PKC proceeds, at least in part, by stimulating channel trafficking and membrane translocation via a mechanism requiring PKCδ [25].…”

Section: (Ltccs) Leading To Contraction In Response To Angii At 1 Rmentioning

confidence: 99%

“…Vascular smooth muscle cells express several subtypes of VGCCs [9]. These channels have been shown to be important for vascular smooth muscle contraction, and some subtypes have been implicated in relaxation mechanisms.…”

Section: Voltage-gated Ca 2+ Channelsmentioning

confidence: 99%

“…Note that many more studies than those cited here can be found in the scientific literature. Comprehensive studies exploring additional aspects of vascular ion channel regulation, vascular smooth muscle excitability, and (micro) vascular function in health and disease can be found in recent reviews [1,[5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ion Channels and Their Regulation in Vascular Smooth Muscle

Syed¹,

Le²,

Navedo³

et al. 2020

Basic and Clinical Understanding of Microcirculation

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Vascular smooth muscle excitability is exquisitely regulated by different ion channels that control membrane potential (E m) and the magnitude of intracellular calcium inside the cell to induce muscle relaxation or contraction, which significantly influences the microcirculation. Among them, various members of the K + channel family, voltage-gated Ca 2+ channels, and transient receptor potential (TRP) channels are fundamental for control of vascular smooth muscle excitability. These ion channels exist in complex with numerous signaling molecules and binding partners that modulate their function and, in doing so, impact vascular smooth muscle excitability. In this book chapter, we will review our current understanding of some of these ion channels and binding partners in vascular smooth muscle and discuss how their regulation is critical for proper control of (micro)vascular function.

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Section: Trp Channelsmentioning

confidence: 99%

Section: (Ltccs) Leading To Contraction In Response To Angii At 1 Rmentioning

confidence: 99%

Section: Voltage-gated Ca 2+ Channelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ion Channels and Their Regulation in Vascular Smooth Muscle

Syed¹,

Le²,

Navedo³

et al. 2020

Basic and Clinical Understanding of Microcirculation

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show abstract

“…They transduce membrane depolarization into an increase in [Ca 2+ ] i by activating a Ca 2+ influx down its large electrochemical gradient. By increasing [Ca 2+ ] i , VOCCs play important roles in the regulation of contractility, vascular tone and gene expression in VSMCs (Jackson, 2000;Ghosh et al, 2017).…”

Section: Voltage-operated Ca 2+ Channels (Voccs)mentioning

confidence: 99%

Remodeling of vascular smoth muscle ion channels involved in purinergic signaling in essential hypertension

Miguel¹

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CaCCs Ca 2+-Activated Cl-Channels CaMKII Ca 2+ /Calmodulin-Dependent Protein Kinase II cAMP Cyclic Adenosine Monophosphate CFTR Cystic Fibrosis Transmembrane Conductance Regulator cGMP Cyclic Guanosine Monophosphate CGRP Calcitonin Gene-Related Peptide CHO Chinese Hamster Ovary Cell Line ClCa Cl-Channel Accessory Proteins ClCs Voltage-Gated Cl-Channels ClICs Intracellular Cl-Channels Cm Membrane Capacitance CO Cardiac Output CVP Central Venous Pressure DAG Diacylglycerol DIDS 4,4′-Diisothiocyanatostilbene-2,2′-Disulfonic Acid UDP Uridine Diphosphate UTP Uridine Triphosphate V clamp Voltage-Clamp Vm Membrane Potential VOCCs Voltage-Operated Ca 2+ Channels VPR Volume Pressure Recording VRACs Volume-Regulated Anion Channels VSM Vascular Smooth Muscle VSMCs Vascular Smooth Muscle Cells αβ-MeATP α,β-Methylene ATP Ca 2+ signaling Changes in [Ca 2+ ] i regulate many biological processes, such as muscle contraction, hormone secretion, gene expression and proliferation. Changes in [Ca 2+ ] i are regulated by the extracellular Ca 2+ influx, by Ca 2+ release from intracellular

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The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells

Ottolini

Sonkusare

2021

Comprehensive Physiology

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Calcium Channels in Vascular Smooth Muscle

Cited by 89 publications

References 195 publications

Ion Channels and Their Regulation in Vascular Smooth Muscle

Ion Channels and Their Regulation in Vascular Smooth Muscle

Remodeling of vascular smoth muscle ion channels involved in purinergic signaling in essential hypertension

The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells

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