Calcium carbimide–ethanol interaction

Abstract

Each of 4 male alcoholic subjects received 0.7 mg/kg calcium carbimide (CC) orally 12 hr before ingestion of 0.25 gm/kg ethanol on 3 separate occasions. The CC-ethanol interaction consisted of increased blood acetaldehyde level and elevated heart rate. For each individual there was small variability in the area under the curve (AUC) values of the blood ethanol level--time course profiles for the 3 experiments, indicating a consistent extent of ethanol absorption. For subjects 1, 2, and 3 there was appreciable intraindividual variability in the AUC and the peak blood acetaldehyde levels of the blood acetaldehyde level--time course curves; the variation in these parameters was small for subjects 4. The intraindividual variability in the peak heart rate response was small for subjects 1 and 2 and appreciable for subjects 3 and 4. Regression analysis of the blood acetaldehyde level--heart rate data for each of the 3 experiments conducted on the 4 subjects revealed that there were positive, linear correlations. There was appreciable intraindividual variability in the slope values for the 3 experiments. The results of this study, conducted on 4 male alcoholics, suggest that for other alcoholic subjects there could be appreciable intraindividual variability in the intensity of the CC-ethanol interaction.

Diethylcarbamoylating/Nitroxylating Agents as Dual Action Inhibitors of Aldehyde Dehydrogenase: A Disulfiram−Cyanamide Merger

“…This evokes a disulfiram−ethanol reaction (DER), a syndrome characterized by facial flushing, tachycardia, and a general feeling of malaise, ostensibly leading to alcohol avoidance . A similar carbimide-ethanol reaction (CER) is elicited by cyanamide vis - à-vis its calcium salt, calcium carbimide, , an alcohol deterrent agent prescribed in Europe, Canada, and Japan. Both DSSD and cyanamide require metabolic bioactivation in vivo before AlDH inhibition is manifest.…”