Abstract:An evaluation has been carried out on the effects of isradipide (Lomir®) on the offspring born from treated mothers and in particular, on the mineralization of the dental germ. Material and Methods. Sixteen female Wistar rats were treated with isradipine (1 mg/rat/day, oral route) and control experiments were run in parallel with untreated animals. The drug was administered along 35 days before mating and 20 days during pregnancy. Blood levels of calcium and phosphate were determined in mothers and newborns. T… Show more
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