Calcium Bioavailability of Nanonized Pearl Powder for Adults

Chen, H.S.; Chang, Jinhua; Wu, Jinglei

doi:10.1111/j.1750-3841.2008.00965.x

Cited by 44 publications

(28 citation statements)

References 35 publications

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“…Nanoemulsion delivery systems have previously been shown to improve bioavailability of nutrients such as delta-tocopherol, calcium and the vitamin-like coenzyme Q-10 molecule [14,27,28]. Pre-clinical studies have shown increased anti-cancer activity of drugs such as tamoxifen and dacarbazine, enhanced antiinflammatory property of aspirin, improved bioactivity of insulin when delivered as nanoemulsions [17][18][19]29].…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of a Nanoemulsion of Lutein is Greater than a Lutein Supplement

Vishwanathan¹,

Wilson²,

Nicolosi³

2009

Nano BioMed ENG

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Lutein, a lipid soluble, oxygenated carotenoid, has shown beneficial effects against the risk factors associated with age-related macular degeneration, cardiovascular disease and also damaging UV radiation. The goal of the present study was to formulate lutein into a stable hydrophilic nanoemulsion that is more bioavailable and consumable in a matrix such as a beverage rather than just supplements. A Microfluidizer® Processor was used to convert an oil-in-water lutein emulsion into a nanoemulsion that is a stable water dispersion and measures 150 nm. After a one wk baseline phase, subjects consumed a lutein supplement pill followed by a lutein nanoemulsion added to orange juice (6 mg/d and 2 mg/d in two separate studies) for one wk each with a 2 wk washout phase between treatments. In study 1, mean serum lutein concentrations (n = 9) increased by 104% (P < 0.001) and 167% (P < 0.001) after the 6 mg supplement and nanoemulsion phases, respectively. In study 2, mean serum lutein concentrations (n = 11) increased by 37% (P < 0.05) and 75% (P < 0.001) after the 2 mg lutein supplement and nanoemulsion phases, respectively Despite the fact that the actual concentration of lutein in the 6 mg and 2 mg nanoemulsions was 10% and 40% lower compared to the supplement form, respectively, due to Microfluidizer ® processor preparation loss, the nanoemulsions resulted in 31% (P < 0.05) and 28% (P < 0.05) greater serum lutein concentrations compared to the supplement.. In conclusion, nanoemulsions of lutein had significantly greater bioavailability than the supplement-pill forms. Keywords:

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Section: Discussionmentioning

confidence: 99%

Bioavailability of a Nanoemulsion of Lutein is Greater than a Lutein Supplement

Vishwanathan¹,

Wilson²,

Nicolosi³

2009

Nano BioMed ENG

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“…The process involves milling micrometer-to nanometersized drug crystals. Nanometer-compared with micrometersized pearl powder has shown a higher bioavailability of Ca in humans as assessed by serum and urinary Ca and serum parathyroid hormone concentrations (35). In rats, supplementing the diet with nano-Ca-enriched milk was reported to increase urinary excretion of Ca (36).…”

Section: Discussionmentioning

confidence: 98%

Diet Calcium Level but Not Calcium Supplement Particle Size Affects Bone Density and Mechanical Properties in Ovariectomized Rats ,

Shahnazari¹,

Martin²,

Legette³

et al. 2009

The Journal of Nutrition

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Calcium (Ca) supplements, especially Ca carbonate (CaCO3), are the main alternative sources of dietary Ca and an important part of a treatment regimen for osteoporosis, the most common metabolic bone disorder of aging and menopause. In a female ovariectomized (OVX) rat model for studying postmenopausal osteoporosis, we tested the hypothesis that a small compared with a large particle size of CaCO3 (13.0- vs. 18.5-mum geometric diameter) would result in increased Ca balance and subsequently bone mass and that this would be affected by dietary Ca level. We used 6-mo-old rats that were OVX either at 6 or 3 mo of age as models of early or stable menopausal status, respectively. The rats received semipurified diets that contained either 0.4 or 0.2% dietary Ca provided from CaCO3 of 2 particle sizes. A group of Sham-operated rats with intact ovaries served as control and were fed 0.4% dietary Ca from large particles. Estrogen deficiency as a result of ovariectomy had an adverse effect on bone density, mineral content, and bone mechanical properties (P < 0.001). Reducing dietary Ca from 0.4 to 0.2% resulted in significant adverse effects on bone density and mechanical properties (P < 0.001). The particle size of CaCO3 did not affect total Ca balance, bone dual energy X-ray absorptiometry and peripheral quantitative computed tomography indices, bone ash and Ca content, or the mechanical determinants of bone strength. We conclude that a decrease in particle size of CaCO3 to 70% of that typically found in Ca supplements does not provide a benefit to overall Ca metabolism or bone characteristics and that the amount of Ca consumed is of greater influence in enhancing Ca nutrition and skeletal strength.

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“…(27) Nanotechnology has been reported to improve the absorption rate of drugs or nutrients due to an increase in surface area and a resulting higher solubility of the particles. (28)(29)(30) Compared with micrometer-sized pearl powder, nanometer-sized pearl powder showed a higher bioavailability of calcium in humans, as (31) Recent studies have also suggested that amorphous materials can potentially be absorbed throughout larger parts of the intestine (ie, jejunum, ileum) allowing a total higher absorption. (32) Indeed, enhanced bioavailability was demonstrated specifically for nanosized amorphous substances.…”

Section: Discussionmentioning

confidence: 99%

Increased Calcium Absorption From Synthetic Stable Amorphous Calcium Carbonate: Double-Blind Randomized Crossover Clinical Trial in Postmenopausal Women

Vaisman

Shaltiel

Daniely

et al. 2014

Journal of Bone and Mineral Research

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Calcium supplementation is a widely recognized strategy for achieving adequate calcium intake. We designed this blinded, randomized, crossover interventional trial to compare the bioavailability of a new stable synthetic amorphous calcium carbonate (ACC) with that of crystalline calcium carbonate (CCC) using the dual stable isotope technique. The study was conducted in the Unit of Clinical Nutrition, Tel Aviv Sourasky Medical Center, Israel. The study population included 15 early postmenopausal women aged 54.9 AE 2.8 (mean AE SD) years with no history of major medical illness or metabolic bone disorder, excess calcium intake, or vitamin D deficiency. Standardized breakfast was followed by randomly provided CCC or ACC capsules containing 192 mg elemental calcium labeled with 44 Ca at intervals of at least 3 weeks. After swallowing the capsules, intravenous CaCl 2 labeled with 42 Ca on was administered on each occasion. Fractional calcium absorption (FCA) of ACC and CCC was calculated from the 24-hour urine collection following calcium administration. The results indicated that FCA of ACC was doubled (AE 0.96 SD) on average compared to that of CCC (p < 0.02). The higher absorption of the synthetic stable ACC may serve as a more efficacious way of calcium supplementation.

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Calcium Bioavailability of Nanonized Pearl Powder for Adults

Cited by 44 publications

References 35 publications

Bioavailability of a Nanoemulsion of Lutein is Greater than a Lutein Supplement

Bioavailability of a Nanoemulsion of Lutein is Greater than a Lutein Supplement

Diet Calcium Level but Not Calcium Supplement Particle Size Affects Bone Density and Mechanical Properties in Ovariectomized Rats ,

Increased Calcium Absorption From Synthetic Stable Amorphous Calcium Carbonate: Double-Blind Randomized Crossover Clinical Trial in Postmenopausal Women

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