Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

“…Thus, LCCBs block development of conditioned place preference (CPP) (Suzuki et al, 1992;Biala and Langwinski, 1996;Shibasaki et al, 2010; but see MartinIverson et al, 1997), where CPP is thought to develop because the acute rewarding properties of abused drugs becomes paired with a particular environment. In addition, drug self-administration is likely maintained, at least in part, by the acute reinforcing effects of abused drugs (Everitt and Robbins, 2005;Sanchis-Segura and Spanagel, 2006), and LCCBs reduce self-administration of alcohol (Engel et al, 1988;Rezvani and Janowsky, 1990;Pucilowski et al, 1992;De Beun et al, 1996;Gardell et al, 1997;Cramer et al, 1998), cocaine (Kuzmin et al, 1992;Martellotta et al, 1994), and morphine (Kuzmin et al, 1992). LCCBs also reduce intake of sucrose (Calcagnetti and Schechter, 1992), saccharin (Pucilowski et al, 1992), and food (De Beun et al, 1996), suggesting that LCCBs might reduce reward more generally or perhaps have nonspecific effects on motor activity.…”

Intravenous Scopolamine Is Potently Self-Administered in Drug-Naive Mice

“…The dose-response curve of contingent mice was similar to findings with cocaine, morphine, or nicotine (Kuzmin et al 1992;Martellotta et al 1995;Rasmussen and Swedberg 1998). Albeit the significant group by unit dose interaction demonstrates that increasing dose affected contingent and yoked control mice differently, a dosedependent increase in nose poking of yoked control mice suggests that nose poking of contingent mice was partly attributable to scopolamine-induced hyperactivity.…”

“…Scopolamine self-administration was demonstrated in a chronic rat model (Glick and Guido 1982), but there is no experimental evidence of possible acute effects of antimuscarinic self-administration. Because drug-naive mice self-administer cocaine, morphine, or nicotine (Kuzmin et al 1992;Martellotta et al 1995; Rasmussen and Swedberg 1998), we investigated if scopolamine could be self-administered in this model, suggesting similar acute and reinforcing properties.…”

Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+ channels

“…The complete absence of BayK and isradipine effects on smooth muscle contraction is surprising because Ca v 1.3 α1 subunits are expressed in aortic muscle (11). In mammals, vasodilation induced by DHP channel blockers and vasoconstriction induced by BayK (13,43) (6,(45)(46)(47).…”