Calcium and zinc decrease intracellular iron by decreasing transport during iron repletion in an in vitro model

Andrews, Mónica; Briones, Lautaro; Pizarro, Fernando; Arredondo, Miguel

doi:10.1007/s00394-017-1535-7

Cited by 4 publications

(6 citation statements)

References 32 publications

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“…The effect of calcium on iron absorption and transfer depended on Ca:Fe ratio and impact time, because the adaptation process was shown with time [22]. Another in vitro study showed that calcium and zinc alter iron metabolism by increasing the activity of FPN, which caused a reduced net iron absorption [11]. The effect of iron overload on calcium malabsorption has been observed in thalassemia [24].…”

Section: Discussionmentioning

confidence: 99%

“…Measurement of essential and toxic elements in serum was conducted based on a previous publication [11]. Samples were mineralized in a high-pressure closed microwave digestion system (Ethos One, Milestone, Sorisole, Italy).…”

Section: Measurement Of Elementsmentioning

confidence: 99%

“…The effect of elements (e.g., manganese, vanadium, and zinc) on iron homeostasis may be mediated through absorption, circulation, and regulation of hepcidin production. The majority of the studies have been conducted to show the effect of low or high supplementation of minerals on iron status [10,11]. In addition, there is data to show interactions between iron and minerals; however, there is little information regarding the effect of iron and folic acid supplementation on mineral metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Suliburska

Chmurzyńska

Kocyłowski³

et al. 2021

IJERPH

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Although simultaneous supplementation of iron and folic acid is justified, the potential interactions between these micronutrients and other elements are poorly known. In this study, we aimed to investigate the effect of iron and folic acid supplementation on the levels of selected essential and toxic elements in the serum of micronutrient-deficient young women. A total of 40 women participated in this study and were divided into two groups: study group (n = 23) (with iron and folate deficiency) and control group (n = 17). The study group received iron and folic acid supplements for 3 months. Blood samples were collected at baseline and after the completion of the study period. Women completed a 3-day food intake record. We calculated the body mass index (BMI) of all the participants. Cellular morphology was analyzed in whole blood, and biochemical parameters were determined in serum. Elements were measured in serum by inductively coupled plasma mass spectrometry (ICP-MS). According to our results, in the case of the study group, the supplementation of iron and folic acid restored their levels; however, it caused a significant decrease in the level of zinc, calcium, and magnesium. In the case of the control group, at the end of the study period, there was a marked decrease in the level of iron. Interestingly, there was an increase in the level of arsenic and vanadium in both groups. In conclusion, simultaneous supplementation of iron and folic acid impairs the level of zinc, calcium, and magnesium in women of childbearing age.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Elementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Suliburska

Chmurzyńska

Kocyłowski³

et al. 2021

IJERPH

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“…Thus, dietary management should be used to increase the absorption of this micronutrient, notably non-heme iron, through stimulatory factors (SF), such as ascorbic acid (ASC) [10] , which reduces and forms a soluble chelate with non-heme iron. Other factors can negatively interfere with the absorption of this mineral, such as calcium (Ca), phytates, and tea polyphenols, through the formation of insoluble chelates or by competition for the same absorption site [11,12,13] . In addition, the absorption rate of dietary iron is influenced by body stores and the characteristics of the diet.…”

Section: Introductionmentioning

confidence: 99%

Estimation of the availability of iron in the school meals of Municipal Centers for Early Childhood Education of a capital city in northeastern Brazil

et al. 2023

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The final stage of iron deficiency is iron deficiency anemia, with repercussions for human health, especially in children under five. Studies conducted in Brazilian public daycare centers show high prevalence of anemia. The present study aims to evaluate the availability of iron in the meals of the Municipal Centers of Early Childhood Education in Maceió. The experimental design comprises: selection of algorithms; menu evaluation; calculation of the estimates; comparison between the estimates obtained and the recommendations; and analysis of correlation between meal constituents, and of the concordance between the absorbable iron estimates. Four algorithms were selected and a monthly menu consisting of 22 days. The correlation analysis showed a moderate positive correlation to animal tissue (AT) vs non-heme iron (r = 0.42; p = 0.04), and negative to AT vs calcium (r = -0.54; p = 0.09) and calcium vs phytates (r = -0.46, p = 0.03). Estimates of absorbable iron ranged from 0.23 to 0.44 mg/day. The amount of iron available, unlike the total amount of iron offered, does not meet the nutritional recommendations on most school days. The Bland-Altman analysis indicated that the Monsen and Balinfty [24] and Rickard et al. [27] showed greater agreement. The results confirm the need to adopt strategies to increase the availability of iron in school meals.

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“…Current results suggest that the deletion of hephaestin and ceruloplasmin leads to systemic iron deficiency and iron overload in local tissues, which disrupts iron homeostasis [10,11]. The effect of elements (such as calcium and zinc) on iron homeostasis may be mediated through its influence on iron absorption, circulating transporters, and regulation of hepcidin production [12,13]. Moreover, excess zinc in the diet is known to induce copper deficiency, leading to a reduction in iron bioavailability, eventually resulting in anemia.…”

Section: Introductionmentioning

confidence: 99%

Iron and Folic Acid Supplementation Affects Mineral Status in Female Rats with a Deficiency of These Micronutrients

Suliburska

Skrypnik

Chmurzyńska

2020

Biol Trace Elem Res

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Supplementation with iron and folic acid is widely recommended in women of childbearing age and during pregnancy; however, the effect of such supplementation on mineral status is not well-known. The aim of this study was to determine the effects of oral iron and folic acid, administered together and separately, on copper, zinc, calcium, and magnesium concentrations in the tissues of rats with a deficiency of both these micronutrients. The experiment was performed on 8-week-old female Wistar rats. In the first stage of the experiment, the animals were randomly assigned to a control group of rats fed the standard diet (AIN-93 M), and to a study group of rats fed a diet deficient in iron and folate. The study group was then randomly divided to four groups: group D was fed a deficit diet, group FE was fed a deficit diet with iron gluconate, the FOL group was fed a deficit diet with folate acid, and the FEFOL group was fed a deficit diet with iron gluconate and folate acid. After 2, 10, and 21 days of the intervention, ten animals from each group were killed. Mineral concentrations were assayed in the liver, spleen, pancreas, heart, and kidneys using atomic absorption spectrometry. Statistical analysis was performed using Statistica 12.0 with the ANOVA test (p < 0.05). It was found that separate supplementation with iron and folic acid significantly decreased copper concentrations in tissues. The deficit in iron and folic acid decreased, and their simultaneous supplementation increased calcium content in the organs. Separate and simultaneous supplementation decreased magnesium status in deficient rats. In conclusion, iron and folic acid, supplemented separately or simultaneously, affect the copper, calcium, and magnesium level in tissues.

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Calcium and zinc decrease intracellular iron by decreasing transport during iron repletion in an in vitro model

Abstract: The present findings suggest that Ca and Zn interfere with iron metabolism. This interference is through an increase in ferroportin activity, which results in a diminished net iron absorption.

Cited by 4 publications

References 32 publications

Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Effect of Iron and Folic Acid Supplementation on the Level of Essential and Toxic Elements in Young Women

Estimation of the availability of iron in the school meals of Municipal Centers for Early Childhood Education of a capital city in northeastern Brazil

Iron and Folic Acid Supplementation Affects Mineral Status in Female Rats with a Deficiency of These Micronutrients

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