Calcium and vitamin D supplementation failed to improve bone mineral density in Indo-Asians suffering from hypovitaminosis D and secondary hyperparathyroidism

Serhan, E; Holland, M R

doi:10.1007/s00296-003-0430-0

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…Vitamin D insufficiency is characterized biochemically by the presence of secondary hyperparathyroidism, [85][86][87][88] reduced calcium absorption, 73,89 higher bone turnover, 90 and increased risk for osteoporosis 88,91 and fractures. 54,[92][93][94][95] Reports suggest that 25(OH)D levels less than 20 ng/mL are associated with secondary hyperparathyroidism and adverse skeletal effects.…”

Section: Secondary Hyperparathyroidismmentioning

confidence: 99%

Vitamin D: an essential component for skeletal health

Wimalawansa

2011

Annals of the New York Academy of Sciences

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Vitamin D deficiency is increasing worldwide. Ultraviolet rays are supposed to provide humans over 80% of our vitamin D requirement; the rest is received through diet and supplements. In addition to enhancing calcium absorption from the intestine and mineralization of the osteoid tissue, vitamin D has many other physiological effects, including neuromodulation, improving muscle strength and coordination, insulin release, immunity and prevention of infections, and curtailing cancer. Whether the increased incidence of vitamin D deficiency is related to increased incidences of nonskeletal disorders remains to be determined. Serum levels of 25-hydroxyvitamin [25(OH)D] above 30 ng/mL indicate vitamin D sufficiency. An additional 1,000 IU of vitamin D/day is sufficient for most lighter-skinned individuals, whereas an extra 2,000 IU/day is needed by the elderly and dark-skinned individuals to maintain normal 25(OH)D levels. Additional research is needed to clarify the relationship between vitamin D and the nonskeletal systems, nonclassic functions, and targets of vitamin D.

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Section: Secondary Hyperparathyroidismmentioning

confidence: 99%

Vitamin D: an essential component for skeletal health

Wimalawansa

2011

Annals of the New York Academy of Sciences

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Vitamin D supplementation for prevention of mortality in adults

Bjelaković¹,

Gluud²,

Nikolova³

et al. 2011

Cochrane Database of Systematic Reviews

189

126

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Vitamin D supplementation for prevention of mortality in adults

Bjelaković

Gluud

Nikolova

et al. 2014

Cochrane Database of Systematic Reviews

440

346

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Vitamin D3 seemed to decrease mortality in elderly people living independently or in institutional care. Vitamin D2, alfacalcidol and calcitriol had no statistically significant beneficial effects on mortality. Vitamin D3 combined with calcium increased nephrolithiasis. Both alfacalcidol and calcitriol increased hypercalcaemia. Because of risks of attrition bias originating from substantial dropout of participants and of outcome reporting bias due to a number of trials not reporting on mortality, as well as a number of other weaknesses in our evidence, further placebo-controlled randomised trials seem warranted.

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Calcium and vitamin D supplementation failed to improve bone mineral density in Indo-Asians suffering from hypovitaminosis D and secondary hyperparathyroidism

Abstract: The failure of BMD to improve could be due to lack of compliance with medication between years 1 and 2, when most patients were under the supervision of primary care. To overcome this, we recommend continuance of blood monitoring at least once a year.

Cited by 8 publications

References 15 publications

Vitamin D: an essential component for skeletal health

Vitamin D: an essential component for skeletal health

Vitamin D supplementation for prevention of mortality in adults

Vitamin D supplementation for prevention of mortality in adults

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