Calcium and vitamin D have a synergistic role in a rat model of kidney stone disease

Letavernier, Emmanuel; Verrier, Cécile; Goussard, Florent; Perez, Joëlle; Huguet, Léa; Haymann, Jean‐Philippe; Baud, Laurent; Bazin, Dominique; Daudon, Michel

doi:10.1016/j.kint.2016.05.027

Cited by 31 publications

(23 citation statements)

References 35 publications

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“…We previously tried to induce Randall's plaque in Sprague Dawley rats exposed to vitamin D and calcium supplementation for 6 months. These animals developed tubular plugs and stones but none of them developed papillary interstitial calcifications [64]. Similar observations have been performed in the genetic hypercalciuric stone forming rat extensively studied by Bushinsky et al [65].…”

Section: Randall's Plaque and Calcification Inhibitorssupporting

confidence: 78%

Pseudoxanthoma Elasticum, Kidney Stones and Pyrophosphate: From a Rare Disease to Urolithiasis and Vascular Calcifications

Letavernier

Bouderlique

Martin

et al. 2019

IJMS

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Pseudoxanthoma elasticum is a rare disease mainly due to ABCC6 gene mutations and characterized by ectopic biomineralization and fragmentation of elastic fibers resulting in skin, cardiovascular and retinal calcifications. It has been recently described that pyrophosphate (a calcification inhibitor) deficiency could be the main cause of ectopic calcifications in this disease and in other genetic disorders associated to mutations of ENPP1 or CD73. Patients affected by Pseudoxanthoma Elasticum seem also prone to develop kidney stones originating from papillary calcifications named Randall’s plaque, and to a lesser extent may be affected by nephrocalcinosis. In this narrative review, we summarize some recent discoveries relative to the pathophysiology of this mendelian disease responsible for both cardiovascular and renal papillary calcifications, and we discuss the potential implications of pyrophosphate deficiency as a promoter of vascular calcifications in kidney stone formers and in patients affected by chronic kidney disease.

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Section: Randall's Plaque and Calcification Inhibitorssupporting

confidence: 78%

Pseudoxanthoma Elasticum, Kidney Stones and Pyrophosphate: From a Rare Disease to Urolithiasis and Vascular Calcifications

Letavernier

Bouderlique

Martin

et al. 2019

IJMS

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“…As observed in other hypercalciuric rat models, animals developed CaP stones but no Randall plaque, despite high CaP supersaturation in urine. 33,34 Of note, patients with PXE affected by Randall plaque had only mild increase in calcium and normal oxalate and phosphate urine concentration, suggesting that hypercalciuria was probably not the main determinant of CaP supersaturation and plaque formation in these patients. On the basis of our results, it seems that calcification inhibitors are probably essential to prevent tissue mineralization in kidney.…”

Section: Discussionmentioning

confidence: 95%

ABCC6 Deficiency Promotes Development of Randall Plaque

Letavernier

Kauffenstein

Huguet

et al. 2018

JASN

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Background Pseudoxanthoma elasticum (PXE) is a genetic disease caused by mutations in the ABCC6 gene that result in low pyrophosphate levels and subsequent progressive soft tissue calcifications. PXE mainly affects the skin, retina, and arteries. However, many patients with PXE experience kidney stones. We determined the prevalence of this pathology in patients with PXE and examined the possible underlying mechanisms in murine models. Methods We conducted a retrospective study in a large cohort of patients with PXE and analyzed urine samples and kidneys from Abcc6 2/2 mice at various ages. We used Yasue staining, scanning electron microscopy, electron microscopy coupled to electron energy loss spectroscopy, and Fourier transform infrared microspectroscopy to characterize kidney calcifications. Results Among 113 patients with PXE, 45 (40%) had a past medical history of kidney stones. Five of six computed tomography scans performed showed evidence of massive papillary calcifications (Randall plaques). Abcc6 2/2 mice spontaneously developed kidney interstitial apatite calcifications with aging. These calcifications appeared specifically at the tip of the papilla and formed Randall plaques similar to those observed in human kidneys. Compared with controls, Abcc6 2/2 mice had low urinary excretion of pyrophosphate. Conclusions The frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and Abcc6 2/2 mice provide a new and useful model in which to study Randall plaque formation. Our findings also suggest that pyrophosphate administration should be evaluated for the prevention of Randall plaque and kidney stones.

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“…In the study of Letavernier et al accompanied vitamin D and elevated calcium intake had a synergistic effect on kidney stone formation in this rat model. Hence, healthcare professionals should be cautious about the cumulative risk of kidney stone formation in elderly population which are high risk for osteoporosis and both vitamin D supplementation and calcium may be prescribed for them (38). …”

Section: Discussionmentioning

confidence: 99%

Nephrolithiasis in elderly population; effect of demographic characteristics

Moudi¹,

Hosseini²,

Bijani³

2016

J Nephropathol

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BackgroundKidney stone (nephrolithiasis) is one of the most common diseases. During the past several decades, its prevalence and incidence have increased markedly in elderly population.ObjectivesThis study was conducted to evaluate the risk factors for nephrolithiasis in elderly population.Patients and MethodsThis study was based on the Amirkola Health and Ageing Project (AHAP). Elderly people with kidney stones in every size, type and number were considered to be the case group and other subjects without a history of kidney stones served as control group. Demographic and anthropometric data, smoking, diabetes and metabolic syndrome (MetS), calcium (Ca), vitamin D, parathyroid hormone (PTH), uric acid and urine pH were compared in both groups.Results In this study, 1390 elderly people with the mean age of 69.37 ± 7.42 years were evaluated which 202 (14.53%) cases had renal stones. The patients with nephrolithiasis were younger (P = 0.010) and had higher uric acid and body mass index (BMI) levels (P = 0.041 and P = 0.006, respectively). Age <75 years, male gender and BMI ≥30 kg/m2 had a significant association with stone formation. The prevalence of diabetes, MetS and smoking in the patients with nephrolithiasis was lower than the subjects without it. ConclusionsThis study suggests that male gender, obesity and age <75 years might be independent risk factors for the development of nephrolithiasis. Hence, low animal protein intake and weight reduction should be included as part of the counseling of senior stone-formers.

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Calcium and vitamin D have a synergistic role in a rat model of kidney stone disease

Cited by 31 publications

References 35 publications

Pseudoxanthoma Elasticum, Kidney Stones and Pyrophosphate: From a Rare Disease to Urolithiasis and Vascular Calcifications

Pseudoxanthoma Elasticum, Kidney Stones and Pyrophosphate: From a Rare Disease to Urolithiasis and Vascular Calcifications

ABCC6 Deficiency Promotes Development of Randall Plaque

Nephrolithiasis in elderly population; effect of demographic characteristics

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