ment of the brain. These casej are in a class by themselves and may not show the warning of previous lead colic or stippled cell rise. Their history is a characteristic story of overwhelm¬ ing lead exposure seen most dramatically in exposure to tetraethyl lead, with sudden onset of irritability followed in rapid succession by marked excitability, mania, coma, and frequently death. Less dramatic types [sometimes seen in children] are characterized by heavy lead exposure with headache, dizziness, confusion and somnolence as the predomi¬ nant picture. Such cases, usually marked by convulsions at the onset, . . . are uncommon in modern industry, where we are concerned with adults. With the ordinary precautions now widely used against excessive lead absorption, lead enceph¬ alopathy has largely vanished from American industry. There is an interesting observation to be made here, that, even in this most intense type of lead intoxication, .