Calcium and osteoporosis

Nordin, B. E. C.

doi:10.1016/s0899-9007(97)83011-0

Cited by 301 publications

(171 citation statements)

References 208 publications

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“…This imbalance would normally be ameliorated by liming, but even a neutral Ca salt can be utilized successfully to enhance soybean nodulation on an acidic soil 254 . There are broader ramifications from the antagonistic effect of K on the Ca content of food crops, because low dietary Ca intake has been linked to several human diseases, including osteoporosis, rickets and colon cancer [255][256][257][258][259] .…”

Section: ----------------------------------------Kg Ha − 1 ----------mentioning

confidence: 99%

The potassium paradox: Implications for soil fertility, crop production and human health

Khan

Mulvaney

Ellsworth

2013

Renew. Agric. Food Syst.

100

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Intensive fertilizer usage of KCl has been inculcated as a prerequisite for maximizing crop yield and quality, and relies on a soil test for exchangeable K in the plow layer to ensure that soil productivity will not be limited by nutrient depletion. The interpretive value of this soil test was rigorously evaluated by: (1) field sampling to quantify biweekly changes and seasonal trends, (2) characterizing the variability induced by air drying and the dynamic nature of soil K reserves and (3) calculating the K balance in numerous cropping experiments. These evaluations leave no alternative but to question the practical utility of soil K testing because test values cannot account for the highly dynamic interchange between exchangeable and non-exchangeable K, exhibit serious temporal instability with or without air drying and do not differentiate soil K buildup from depletion. The need for routine K fertilization should also be questioned, considering the magnitude and inorganic occurrence of profile reserves, the recycling of K in crop residues and the preferential nature of K uptake. An extensive survey of more than 2100 yield response trials confirmed that KCl fertilization is unlikely to increase crop yield. Contrary to the inculcated perception of KCl as a qualitative commodity, more than 1400 field trials predominately documented a detrimental effect of this fertilizer on the quality of major food, feed and fiber crops, with serious implications for soil productivity and human health.

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Section: ----------------------------------------Kg Ha − 1 ----------mentioning

confidence: 99%

The potassium paradox: Implications for soil fertility, crop production and human health

Khan

Mulvaney

Ellsworth

2013

Renew. Agric. Food Syst.

100

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“…3,4) On the other hand, although associations have been shown between calcium intake and dental status or bone mineral density, 5,6) associations between cardiovascular variables (blood pressure and heart rate) and dental status or bone mineral density have not yet been determined.…”

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Association of Dental Status With Blood Pressure and Heart Rate in 80-Year-old Japanese Subjects.

et al. 2003

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SUMMARYPeriodontal disease is one of the main reasons for the loss of teeth in elderly subjects, and it has been reported that periodontal disease is a potential risk factor for cardiovascular disease. However, little data is available regarding the association between dental status and blood pressure or heart rate in elderly individuals, particularly in subjects over 80 years old. We studied the cross-sectional association between dental status and blood pressure or heart rate in 499 Japanese (195 men and 304 women) who were 80 years old. The subjects were divided into 4 groups according to the number of original teeth; ie, edentulous (n = 176), 1 to 9 teeth (n = 141), 10 to 19 teeth (n = 109), and more than 20 teeth (n = 73). Mean systolic and diastolic blood pressures did not differ among the groups. However, heart rate decreased from 71.6 and 72.2 /min in the edentulous and 1 to 9 teeth groups, respectively, to 67.3 and 67.4 /min in the 10 to 19 teeth and more than 20 teeth groups, respectively (test for trend, P = 0.0008). In multiple regression analysis, the inverse association between the number of teeth and heart rate was statistically significant independently of other confounding factors. These results are the first to show a close inverse relationship between the number of teeth and heart rate in octogenariars, although the underlying mechanisms have not been determined. (Jpn Heart J 2003; 44: 943-951)

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“…During the early period of the formation of bone mass peak, the bone formation is higher than the bone resorption (Nordin, 1997). Thus, the bone mass accumulates and increases until bone mass peak term (35 _ 40 years old).…”

Section: Effects Of Epp On Bone Growing Of Ratsmentioning

confidence: 99%

Effectiveness of Carp Egg Phosphopeptide on Inhibiting the Formation of Insoluble Ca Salts in vitro and Enhancing Ca Bioavailability in vivo

Huang

Liu

et al. 2014

FSTR

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AbbreviationsEPP; carp egg phosphopeptide, CPP; casein phosphopeptide, Hy; carp egg tryptic hydrolysate, Fu; the fraction after ultrafiltration with molecular weight 1 _ 5KDa, ALP; alkaline phosphatase, BMD; bone mineral density *To whom correspondence should be addressed. E-mail: mingyzouc@163.com IntroductionCa is an important mineral element to maintain human health, which plays an important role in the formation of bones and teeth, neurotransmitter release, muscle composition, and heart beat regulation. Ninety-nine percent of Ca of human body exists in the bones, and the remaining 1% is in teeth, soft tissue, blood, and extracellular fluid (Straub, 2007 Carp egg phosphopeptide (EPP) with Ca binding activity was isolated from tryptic hydrolysate by ultrafiltrationand hydroxylapatite chromatography. EPP mainly consists of 3.99 ± 0.12% P (w/w) and 20.36 ± 0.50% serine residues (w/w). In vitro EPP exhibited high Ca binding ability which was slightly lower than that of casein phosphopeptide (CPP) and could inhibit the formation of insoluble Ca salts. In vivo the effects of EPP on increasingCa bioavailability were further studied in Ca-deficiency rats. All rats were randomly divided into five groups, one group served as the normal group to feed with a normal-Ca diet including CaCO 3 for 8 weeks, another as the Cadeficiency group to feed with a low-Ca diet for 8 weeks, the other three groups to feed with the low-Ca diet for 4 weeks and then randomly assigned to the control group and two experimental groups. The control group was switched to the normal-Ca diet for 4 weeks. The experimental groups were fed with the normal-Ca diet containing EPP and CPP for 4 weeks respectively (marked as the EPP group and CPP group). During the experimental period, Ca absorption and its accumulation in bone was significantly increased by EPP supplementation. The levels of serum Ca, bone mineral density, bone Ca content and biomechanical properties of the EPP group were significantly higher than those of control group ( p < 0.05), but similar to the CPP group ( p > 0.05). EPP is expected to become a novel Ca nutraceutical additive in food industry due to enhancing Ca bioavailability by its intake.

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Calcium and osteoporosis

Cited by 301 publications

References 208 publications

The potassium paradox: Implications for soil fertility, crop production and human health

The potassium paradox: Implications for soil fertility, crop production and human health

Association of Dental Status With Blood Pressure and Heart Rate in 80-Year-old Japanese Subjects.

Effectiveness of Carp Egg Phosphopeptide on Inhibiting the Formation of Insoluble Ca Salts in vitro and Enhancing Ca Bioavailability in vivo

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