Calcium and CaSR/IP3R in prostate cancer development

Wang, Liyang; Xu, Meng; Li, Zhong-Guang; Shi, Mengting; Zhou, Xin; Jiang, Xiaolong; Bryant, Joseph; Balk, Steven P.; Ma, Jianjie; Isaacs, William B.; Xu, Xuehong

doi:10.1186/s13578-018-0217-3

Cited by 21 publications

(14 citation statements)

References 36 publications

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“…Pharmacological evidence demonstrated that the attendance of IP3 and ryanodine receptor channels signaling as calcium-induced calcium release are responsible for this calcium homeostasis, because these derivatives with infrequent peroxide bridge have several P-type Ca 2+ ATPases involved in the ER-type reuptake mechanism at the proposed target sites 70 . Recently, research into extracellular Ca 2+ linking to the trichocysts associated with fastest dense core-secretory vesicle exocytosis has elucidated that calcium homeostasis is critical in many physiological and pathological processes including protein secretion, motility, cell invasion, and differentiation 51 , 75 . With the involvement of putative mitochondrial Ca(2+)/H(+) exchanger, IP3/cADPR-mediated endoreticular calcium release via RyRs, and parasites-only CDPKs, our suggestion of a combination of different compounds from diverse calcium signaling pathways, such as a cocktail of BKI plus artemisinin, is worthy of more intensive studies.…”

Section: Essential Cdpks As Potential Drug Targets Against the Malarimentioning

confidence: 99%

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

Ghartey‐Kwansah

Yin

et al. 2020

Cell Transplant

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Apicomplexan parasites have challenged researchers for nearly a century. A major challenge to developing efficient treatments and vaccines is the parasite’s ability to change its cellular and molecular makeup to develop intracellular and extracellular niches in its hosts. Ca2+ signaling is an important messenger for the egress of the malaria parasite from the infected erythrocyte, gametogenesis, ookinete motility in the mosquito, and sporozoite invasion of mammalian hepatocytes. Calcium-dependent protein kinases (CDPKs) have crucial functions in calcium signaling at various stages of the parasite’s life cycle; this therefore makes them attractive drug targets against malaria. Here, we summarize the functions of the various CDPK isoforms in relation to the malaria life cycle by emphasizing the molecular mechanism of developmental progression within host tissues. We also discuss the current development of anti-malarial drugs, such as how specific bumped kinase inhibitors (BKIs) for parasite CDPKs have been shown to reduce infection in Toxoplasma gondii, Cryptosporidium parvum, and Plasmodium falciparum. Our suggested combinations of BKIs, artemisinin derivatives with peroxide bridge, and inhibitors on the Ca(2+)-ATPase PfATP6 as a potential target should be inspected further as a treatment against malaria.

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Section: Essential Cdpks As Potential Drug Targets Against the Malarimentioning

confidence: 99%

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

Ghartey‐Kwansah

Yin

et al. 2020

Cell Transplant

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“…IP 3 R are modulated in response to androgen deprivation in LnCAP cells [10]. Additionally, an analysis of the TCGA database revels that IP 3 R is altered in 30% of prostate tumors [11]. Together this information indicates that PMCA and IP 3 R are good targets for treating advanced, androgen-independent prostate cells.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol derivatives increase cytosolic calcium by inhibiting plasma membrane ATPase and inducing calcium release from the endoplasmic reticulum in prostate cancer cells

Peterson

Crowther

Andrus

et al. 2019

Biochemistry and Biophysics Reports

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Resveratrol (RES) is a putative chemotherapeutic naturally found in grapes, peanuts, and Japanese knotweed. Previous studies demonstrate that RES modulates calcium signaling as part of its chemotherapeutic activity. In this study, we determined the chemotherapeutic activity of three RES esters that have been modified at the 4’ hydroxyl by the addition of pivalate, butyrate, and isobutyrate. All of the RES derivatives disrupted the calcium signaling in prostate cancer cells more than the parent compound, RES. Further, we demonstrate that the RES derivatives may disrupt the calcium homeostasis by activating calcium release from the endoplasmic reticulum and inhibiting plasma membrane Ca 2+ -ATPase. The pivalated and butyrated RES derivatives decreased cell viability significantly more than RES. Because pivalated and butyrated RES are more effective than RES at targeting calcium signaling pathways, pivalated and butyrated RES may serve as more effective chemotherapeutics.

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“…It has been suggested that inositol 1,4,5-trisphosphate receptor (IP3R), a calcium ion channel, is correlated with invasive behavior and progression of several types of neoplasia including breast cancer, prostate cancer, uterine cancer, ovarian cancer, and pulmonary adenocarcinoma [9][10][11][12]. Its expression is also associated with poor prognosis in colorectal carcinoma [13].…”

Section: Introductionmentioning

confidence: 99%

Immunolocalization of IP3R and V-ATPase in Ameloblastomas

Giovanini

Priesnitz

Til

et al. 2019

Head and Neck Pathol

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The goal of this study was to investigate the immunolocalization of inositol 1,4,5-trisphosphate receptor (IP3R) and vacuolar ATPase (V-ATPase) in ameloblastomas with special attention to the invasive front. Thirty-seven cases of previously diagnosed formalin-fixed paraffin-embedded (FFPE) human ameloblastoma samples were selected for this study. The samples were grouped according to the predominant histologic pattern and comprised twelve plexiform, eighteen follicular, and seven unicystic ameloblastomas. Of the unicystic variants, six demonstrated purely luminal and intraluminal growth, and one displayed mural extension. One granular cell variant was included in the follicular ameloblastoma group. All specimens were evaluated for IP3R and V-ATPase expression by immunohistochemistry (IHC). IP3R was positive in columnar cells, similar to ameloblasts, and non-peripheral cells in all samples. In the area of tumor protrusion and front of invasion, membranous and cystoplasmic IP3R expression was observed. In contrast, areas adjacent to tumoral protrusion demonstrated only membranous staining patterns. V-ATPase was not expressed in peripheral columnar cells of the unicystic and granular cell variants of ameloblastoma; however, strong staining was present in these cells in plexiform ameloblastomas, follicular ameloblastomas, and areas of mural growth of unicystic ameloblastomas. In areas of tumor protrusion, reactivity for V-ATPase was observed with both membranous and cytoplasmic staining, while other areas showed only membranous V-ATPase. These findings suggest that concomitant immunolocalization of IP3R and V-ATPase, with both cytoplasmic and membranous expression in the peripheral columnar cells, may indicate the invasive potential of ameloblastomas. Furthermore, these results suggest the tumoral spread of ameloblastomas may be correlated with the autophagy process and channelopathy. The expression of these proteins could establish a baseline for future research and provide therapeutic targets for treatment of ameloblastomas.

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Calcium and CaSR/IP3R in prostate cancer development

Cited by 21 publications

References 36 publications

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

Calcium-dependent Protein Kinases in Malaria Parasite Development and Infection

Resveratrol derivatives increase cytosolic calcium by inhibiting plasma membrane ATPase and inducing calcium release from the endoplasmic reticulum in prostate cancer cells

Immunolocalization of IP3R and V-ATPase in Ameloblastomas

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