Calcium and carcinogenesis of the mammary gland

Carroll, K. K.; Jacobson, E. A.; Eckel, Lisa A.; Newmark, Harold L.

doi:10.1093/ajcn/54.1.206s

Cited by 32 publications

(14 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2007;167: [1050][1051][1052][1053][1054][1055][1056][1057][1058][1059] E XPERIMENTAL DATA IN ANImals have linked calcium and vitamin D intake to breast cancer prevention. [1][2][3][4] Female rats fed diets low in calcium and vitamin D developed significantly more experimental mammary tumors than rats fed adequate levels of calcium and vitamin D. 1,4 Increasing dietary calcium and vitamin D intake in female mice also regressed the adverse changes in the mammary gland induced by a highfat diet. 2,3 Adequate intake of calcium from calcium-rich diets (which may include dairy products and supplements) helps to enhance calcium concentrations to maintain adequate intracellular calcium levels.…”

Section: Discussionmentioning

confidence: 99%

Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women

Lin

Manson²,

Lee³

et al. 2007

Arch Intern Med

236

168

View full text Add to dashboard Cite

Background: Animal data suggest the potential anticarcinogenic effects of calcium and vitamin D on breast cancer development. However, epidemiologic data relating calcium and vitamin D levels to breast cancer have been inconclusive.Methods: We prospectively evaluated total calcium and vitamin D intake in relation to breast cancer incidence among 10 578 premenopausal and 20 909 postmenopausal women 45 years or older who were free of cancer and cardiovascular disease at baseline in the Women's Health Study. Baseline dietary intake was assessed by a food frequency questionnaire. We used Cox proportional hazards regression to estimate hazard ratios and 95% confidence intervals.

show abstract

Section: Discussionmentioning

confidence: 99%

Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women

Lin

Manson²,

Lee³

et al. 2007

Arch Intern Med

236

168

View full text Add to dashboard Cite

show abstract

“…Several possible mechanisms behind these protective effects have been hypothesized. For breast cancer, calcium has been proposed to reduce fat-induced cell proliferation by maintaining intracellular calcium concentrations (Jacobson et al, 1989;Carroll et al, 1991;Newmark, 1994;Lipkin and Newmark, 1999;Xue et al, 1999). Vitamin D modulates calcium metabolism, inhibits cellular proliferation, induces differentiation and apoptosis and (Ziegler et al, 1991) inhibits angiogenesis in normal and malignant breast cells Xue et al, 1999;Shin et al, 2002;Cui and Rohan, 2006;Deeb et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

et al. 2010

View full text Add to dashboard Cite

Background/Objectives: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. Subjects/Methods: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. Results: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend ¼ 0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend ¼ 0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend ¼ 0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend ¼ 0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P ¼ 0.819; and CIN3: interaction P ¼ 0.101). Conclusion: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.

show abstract

“…Studies showed that high intake of vitamin D and calcium markedly reduced the incidence of mammary cancer in experimental mice and rats that were given high-fat diets [122][123]. Furthermore, high levels of vitamin D and calcium intake was able to reduce the incidence of mammary cancer in rats [123].…”

Section: Vitamin D and Breast Cancer Riskmentioning

confidence: 99%

Vitamin D and Female Reproduction

Elhusseini¹,

Lizneva²,

Gavrilova-Jordan³

et al. 2017

A Critical Evaluation of Vitamin D - Basic Overview

View full text Add to dashboard Cite

Vitamin D deficiency has an impact on the reproduction of more than 40% of reproductive age women globally. Fibroids are more common among African-American females owing to their decreased milk consumption and reduced absorption of ultraviolet rays, supporting the relation between vitamin D deficiency and fibroid development. Vitamin D has an inhibitory effect on leiomyoma cells by suppression of proliferation cell nuclear antigen (PCNA), BCL-2, BCL-w, CDK1, and catechol-Omethyltransferase (COMT) protein levels. A growing evidence support the relationship between vitamin D deficiency and endometriosis through overexpression of vitamin D recseptor (VDR) and α-hydroxylase enzyme, however, it is still unclear if the endometriosis patients could benefit from vitamin D supplementation. Effect of vitamin D supplementation on the metabolic outcomes of polycystic ovary (PCO) has been studied and reveled that it is negatively correlated with fasting glucose, fasting insulin, triglycerides, C-reactive protein, free androgen index, and Dehydroepiandrosterone (DHEAS) and positively associated with quantitative insulin sensitivity check index (QUICKI), high density lipoprotein cholesterol (HDL-C), and sexual hormone binding globulin (SHBG), whereas its impact on the ovarian function is still unclear. Vitamin D deficiency may worse the obstetrical outcomes, including preeclampsia, gestational diabetes, low birth weight, increased cesarean section rate, neonatal asthma, seizures, and preterm labor. The relationship between serum levels of 25-hydroxy-vitamin D (25(OH) D) and pregnancy rates in ART is still debatable, with the need to conduct more clinical trials toward it. The in vitro antiproliferative and prodifferentiative effect of vitamin D might find a role in control of hyperplastic overactive bladder. Several studies support that vitamin D deficiency constitutes a risk factor for development of many types of cancer such as breast, ovarian, and colorectal.

show abstract

Calcium and carcinogenesis of the mammary gland

Cited by 32 publications

References 4 publications

Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women

Intakes of Calcium and Vitamin D and Breast Cancer Risk in Women

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

Vitamin D and Female Reproduction

Contact Info

Product

Resources

About