Calcium alginate microparticles containing anti-TB drugs

Abstract

<p>In this work the results of immobilization of anti-TB drugs rifampicin and fluconazole in alginate hydrogels were presented. Release kinetics of rifampicin and fluconazole fromswollen and dried calcium alginate microparticles were studied. It was revealed that the release of the drug from the swollen microparticles is higher than from the dried ones. Also the release of rifampicin from alginate microparticles coated with chitosan layer was studied. It was investigated that the thicker the layer of chitosan is, the slower drug releases. Thus, for the chitosan coating thickness of 25 microns, 95-100% rifampicin diffuses from the microparticles for 600-720 min. When using alginate-coated particles with a thickness of 65 microns and 125, during this time interval 60-70% drug released, respectively.</p>

The Synthesis of Alginate Microparticles and Nanoparticles

“…Further drug release rate decrease by 30% for up to 12 hours was observed with the increase of chitosan shell thickness from 25μm to 125μm that was, in turn, determined by the employed chitosan concentration. The use of these beads as antitubercular medicaments with prolonged action was suggested [119]. A slightly different technique was employed for the encapsulation of sunflower oil extract from tunic of ascidia.…”