Calcium Alginate Film Used for Guided Bone Regeneration in Mandible Defects in a Rabbit Model

He, Hong; Huang, Jian-qi; Ping, Fei-yun; Sun, Gang; Chen, Guan-Fu

doi:10.1179/crn.2008.009

Cited by 19 publications

(15 citation statements)

References 13 publications

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“…In relation to the evaluation periods, there is great variation in the scientific literature, ranging from seven days to several months [ 23 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. The cycle of bone remodeling in rabbits is six weeks, different from dogs (12 weeks) and humans (17 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…Although the gingiva and oral environment present distinct histology of the scalp, the rabbit calvarial models are very useful for the study of the technique of guided bone regeneration, since the bone of the craniofacial area presents common characteristics of healing. This model is well known and used with diverse types of materials and techniques [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Guided bone regeneration with polypropylene barrier in rabbit's calvaria: A preliminary experimental study

Lucca¹,

Marques²,

Weinfeld

2018

Heliyon

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ObjectivesThis study aimed to evaluate the bone formation process in experimental defects created on rabbit calvarial, in which one of the bone defects was covered by the impermeable membrane before suturing the skin flap, while the other was closed only by the cutaneous flap. The experimental holes were filled only by the blood clot.Material and methodsSixteen New Zealand female rabbits weighing between 3.5 and 4 kg were used. Two experimental bone defects were made in the rabbit calvarial. The holes were filled only with the blood clot and one of them was covered with an impermeable polypropylene membrane. A histological analysis was made at 21 and 42 days following the surgery. Histological evaluation consisted of the following: 1. inflammatory process; 2. Bone repair; 3. Bone remodeling; 4. Presence of osteoid matrix and mineralization, and 5. Formation of hematopoietic tissue. Each characteristic was analyzed semi quantitatively.ResultsThere was a statistical difference between the test and the control group at 21 days of healing in the following items: presence of cementation line (p = 0.012), presence of osteoid tissue (p = 0.012), and trabecular bone tissue development and mineralization (p = 0.012). A greater amount of lamellar bone tissue (mature) was also observed in the test group compared to the control group.ConclusionThe semiquantitative analysis showed that at 21 days there was a superiority of the repair process in the test group; at 42 days there was no significant difference in bone formation between the two groups; and that the polypropylene membrane is feasible to be used in GBR.Clinical significanceThe impermeable polypropylene barrier is feasible for use in the guided bone regeneration technique. It can be used only on the blood clot, without the need for grafting, and can be easily removed a few days after surgery. These results are unprecedented.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Guided bone regeneration with polypropylene barrier in rabbit's calvaria: A preliminary experimental study

Lucca¹,

Marques²,

Weinfeld

2018

Heliyon

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“…Alginate is a biocompatible, anionic polymer that can be obtained from brown seaweed and achieves a similar structure to extracellular matrices when cross‐linked to hydrogels . Although there is evidence indicating that both chitosan‐ and alginate‐based membranes promote bone regeneration in experimental bone defects and are suitable materials for GBR , no papers describing the clinical results were found in the literature.…”

Section: Membrane Properties and Their Modificationsmentioning

confidence: 99%

Guided bone regeneration: materials and biological mechanisms revisited

Elgali

Omar

Dahlin

et al. 2017

European J Oral Sciences

557

619

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Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non‐osteogenic tissues from interfering with bone regeneration is a key principle of GBR. Membrane materials possess a number of properties which are amenable to modification. A large number of membranes have been introduced for experimental and clinical verification. This prompts the need for an update on membrane properties and the biological outcomes, as well as a critical assessment of the biological mechanisms governing bone regeneration in defects covered by membranes. The relevant literature for this narrative review was assessed after a MEDLINE/PubMed database search. Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. Nevertheless, the precise role of membrane porosities for the barrier function of GBR membranes still awaits elucidation. Novel experimental findings also suggest an active role of the membrane compartment per se in promoting the regenerative processes in the underlying defect during GBR, instead of being purely a passive barrier. The optimization of membrane materials by systematically addressing both the barrier and the bioactive properties is an important strategy in this field of research.

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“…The model was chosen to simulate a marginal mandibulectomy as often required in the management of oral carcinomas 7. Many models of nonsegmental defects have been described, such as circular defects in the angle,8 partial lateral defects in the premolar/molar region9 or 10 × 5 mm defects at the edge of the horizontal branch 10. Young et al described a model using a 10‐mm full thickness bicortical and cylindrical—but not segmental—defect 9.…”

Section: Discussionmentioning

confidence: 99%

Alveolar ridge augmentation in irradiated rabbit mandibles

Jégoux

Aguado

Cognet³

et al. 2009

J Biomedical Materials Res

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Oral carcinomas are frequently treated with a nonsegmental mandibulectomy plus radiotherapy. Improving the quality of life of these patients depends on the possibilities for dental rehabilitation. The aim of this study was to increase the alveolar ridge height. Twelve white New Zealand rabbits underwent surgery to produce a 11 x 9 x 7 mm(3) horizontal bicortical full-thickness defect at the alveolar ridge of the left mandible. Six were implanted with a composite associating resorbable collagen membrane filled with micro-macroporous biphasic calcium phosphate granules. After a daily radiation delivery schedule for 4 weeks, a total autologous bone marrow graft was injected percutaneously into the center of the implant. All animals were sacrificed at 16 weeks. Successful osseous colonization was observed in all implants. Significant ridge augmentation was observed (p = 0.0349) in the implanted group compared with the control group. This study contributed to producing an experimental model for oncological mandible defects in rabbits.

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Calcium Alginate Film Used for Guided Bone Regeneration in Mandible Defects in a Rabbit Model

Cited by 19 publications

References 13 publications

Guided bone regeneration with polypropylene barrier in rabbit's calvaria: A preliminary experimental study

Guided bone regeneration with polypropylene barrier in rabbit's calvaria: A preliminary experimental study

Guided bone regeneration: materials and biological mechanisms revisited

Alveolar ridge augmentation in irradiated rabbit mandibles

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